Open Access

Science, volume 371, issue 6530

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

Paul-Albert Koenig ^{1, 2}

Hrishikesh Das ³

Hejun Liu ⁴

Beate M Kümmerer ^{5, 6}

Florian N Gohr ¹

Lea Marie Jenster ¹

Lisa Dj Schiffelers ¹

Yonas M Tesfamariam ¹

Miki Uchima ¹

Jennifer Deborah Wuerth ¹

Karl Gatterdam ⁷

Natalia Ruétalo ⁸

Maria H. Christensen ¹

Caroline I Fandrey ¹

Sabine Normann ¹

Jan Mp Tödtmann ²

Steffen Pritzl ²

Leo Hanke ⁹

Jannik Boos ¹⁰

Meng Yuan ⁴

Xue-Yong Zhu ⁴

J. Schmid-Burgk ¹¹

Hiroki Kato ¹²

Michael Schindler ⁸

I. H. Wilson ^{4, 13}

Matthias Geyer ⁷

Kerstin U. Ludwig ¹⁰

B. Martin Hallberg ^{3, 14}

Nicholas Wu ^{15, 16, 17}

Florian I. Schmidt ^{1, 2}

Hide authors affiliations Show authors affiliations: 17 affiliations

Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany. |

Core Facility Nanobodies, Medical Faculty, University of Bonn, 53127 Bonn, Germany. |

Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden. |

⁴

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. |

⁵

Institute of Virology, Medical Faculty, University of Bonn, 53127 Bonn, Germany. |

⁶

German Centre for Infection Research (DZIF), partner site Bonn-Cologne, 53127 Bonn, Germany. |

⁷

Institute of Structural Biology, Medical Faculty, University of Bonn, 53127 Bonn, Germany. |

⁸

Institute for Medical Virology and Epidemiology, Section Molecular Virology, University Hospital Tübingen, 72076 Tübingen, Germany. |

⁹

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden. |

¹⁰

Institute of Human Genetics, Medical Faculty, University of Bonn, 53127 Bonn, Germany. |

¹¹

Institute for Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University of Bonn, 53127 Bonn, Germany. |

¹²

Institute of Cardiovascular Immunology, Medical Faculty, University of Bonn, 53127 Bonn, Germany. |

¹³

The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. |

¹⁴

Centre for Structural Systems Biology (CSSB) and Karolinska Institutet VR-RÅC, Notkestrasse 85, 22607 Hamburg, Germany. |

¹⁵

Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. |

¹⁶

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. |

¹⁷

Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. |

Publication type: Journal Article

Publication date: 2021-02-12

American Association for the Advancement of Science (AAAS)

Journal: Science

Quartile SCImago

Quartile WOS

Impact factor: 56.9

ISSN: 00368075, 10959203

DOI: 10.1126/science.abe6230

Copy DOI

Multidisciplinary

Abstract

A double punch against SARS-CoV-2

Monoclonal antibodies are an important weapon in the battle against COVID-19. However, these large proteins are difficult to produce in the needed quantities and at low cost. Attention has turned to nanobodies, which are aptly named, single-domain antibodies that are easier to produce and have the potential to be administered by inhalation. Koenig et al. describe four nanobodies that bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prevent infection of cells (see the Perspective by Saelens and Schepens). Structures show that the nanobodies target two distinct epitopes on the SARS-CoV-2 spike protein. Multivalent nanobodies neutralize virus much more potently than single nanobodies, and multivalent nanobodies that bind two epitopes prevent the emergence of viral escape mutants.

Science , this issue p. eabe6230 ; see also p. 681

By date By citations

Top-30

Citations by journals

	2 4 6 8 10 12
Frontiers in Immunology	Frontiers in Immunology, 12, 3.79% Frontiers in Immunology 12 publications, 3.79%
Nature Communications	Nature Communications, 11, 3.47% Nature Communications 11 publications, 3.47%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 7, 2.21% International Journal of Molecular Sciences 7 publications, 2.21%
Viruses	Viruses, 7, 2.21% Viruses 7 publications, 2.21%
Scientific Reports	Scientific Reports, 5, 1.58% Scientific Reports 5 publications, 1.58%
mAbs	mAbs, 5, 1.58% mAbs 5 publications, 1.58%
Communications Biology	Communications Biology, 4, 1.26% Communications Biology 4 publications, 1.26%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 4, 1.26% International Journal of Biological Macromolecules 4 publications, 1.26%
iScience	iScience, 4, 1.26% iScience 4 publications, 1.26%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 4, 1.26% Proceedings of the National Academy of Sciences of the United States of America 4 publications, 1.26%
Cells	Cells, 3, 0.95% Cells 3 publications, 0.95%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 3, 0.95% Frontiers in Molecular Biosciences 3 publications, 0.95%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 3, 0.95% Signal Transduction and Targeted Therapy 3 publications, 0.95%
Cell Reports	Cell Reports, 3, 0.95% Cell Reports 3 publications, 0.95%
Antiviral Research	Antiviral Research, 3, 0.95% Antiviral Research 3 publications, 0.95%
Advanced Science	Advanced Science, 3, 0.95% Advanced Science 3 publications, 0.95%
Journal of the American Chemical Society	Journal of the American Chemical Society, 3, 0.95% Journal of the American Chemical Society 3 publications, 0.95%
EMBO Reports	EMBO Reports, 3, 0.95% EMBO Reports 3 publications, 0.95%
PLoS Pathogens	PLoS Pathogens, 3, 0.95% PLoS Pathogens 3 publications, 0.95%
Microorganisms	Microorganisms, 2, 0.63% Microorganisms 2 publications, 0.63%
Vaccines	Vaccines, 2, 0.63% Vaccines 2 publications, 0.63%
Frontiers in Microbiology	Frontiers in Microbiology, 2, 0.63% Frontiers in Microbiology 2 publications, 0.63%
Nature	Nature, 2, 0.63% Nature 2 publications, 0.63%
Journal of Nanobiotechnology	Journal of Nanobiotechnology, 2, 0.63% Journal of Nanobiotechnology 2 publications, 0.63%
Journal of Biological Chemistry	Journal of Biological Chemistry, 2, 0.63% Journal of Biological Chemistry 2 publications, 0.63%
Nano Today	Nano Today, 2, 0.63% Nano Today 2 publications, 0.63%
Virologica Sinica	Virologica Sinica, 2, 0.63% Virologica Sinica 2 publications, 0.63%
Current Opinion in Virology	Current Opinion in Virology, 2, 0.63% Current Opinion in Virology 2 publications, 0.63%
Structure	Structure, 2, 0.63% Structure 2 publications, 0.63%
	2 4 6 8 10 12

Citations by publishers

	10 20 30 40 50 60 70
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 62, 19.56% Cold Spring Harbor Laboratory 62 publications, 19.56%
Elsevier	Elsevier, 55, 17.35% Elsevier 55 publications, 17.35%
Springer Nature	Springer Nature, 51, 16.09% Springer Nature 51 publications, 16.09%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 26, 8.2% Multidisciplinary Digital Publishing Institute (MDPI) 26 publications, 8.2%
Frontiers Media S.A.	Frontiers Media S.A., 21, 6.62% Frontiers Media S.A. 21 publications, 6.62%
Wiley	Wiley, 19, 5.99% Wiley 19 publications, 5.99%
American Chemical Society (ACS)	American Chemical Society (ACS), 18, 5.68% American Chemical Society (ACS) 18 publications, 5.68%
EMBO press	EMBO press, 6, 1.89% EMBO press 6 publications, 1.89%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 6, 1.89% Public Library of Science (PLoS) 6 publications, 1.89%
Taylor & Francis	Taylor & Francis, 6, 1.89% Taylor & Francis 6 publications, 1.89%
Oxford University Press	Oxford University Press, 6, 1.89% Oxford University Press 6 publications, 1.89%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 6, 1.89% American Association for the Advancement of Science (AAAS) 6 publications, 1.89%
American Society for Microbiology	American Society for Microbiology, 5, 1.58% American Society for Microbiology 5 publications, 1.58%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 4, 1.26% Proceedings of the National Academy of Sciences (PNAS) 4 publications, 1.26%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 0.95% Royal Society of Chemistry (RSC) 3 publications, 0.95%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 2, 0.63% American Society for Biochemistry and Molecular Biology 2 publications, 0.63%
KeAi Communications Co.	KeAi Communications Co., 2, 0.63% KeAi Communications Co. 2 publications, 0.63%
Microbiology Society	Microbiology Society, 1, 0.32% Microbiology Society 1 publication, 0.32%
NEJM Group	NEJM Group, 1, 0.32% NEJM Group 1 publication, 0.32%
Portland Press	Portland Press, 1, 0.32% Portland Press 1 publication, 0.32%
Dove Medical Press	Dove Medical Press, 1, 0.32% Dove Medical Press 1 publication, 0.32%
Walter de Gruyter	Walter de Gruyter, 1, 0.32% Walter de Gruyter 1 publication, 0.32%
Cambridge University Press	Cambridge University Press, 1, 0.32% Cambridge University Press 1 publication, 0.32%
Rockefeller University Press	Rockefeller University Press, 1, 0.32% Rockefeller University Press 1 publication, 0.32%
American Institute of Mathematical Sciences (AIMS)	American Institute of Mathematical Sciences (AIMS), 1, 0.32% American Institute of Mathematical Sciences (AIMS) 1 publication, 0.32%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.32% eLife Sciences Publications 1 publication, 0.32%
Scientific Scholar	Scientific Scholar, 1, 0.32% Scientific Scholar 1 publication, 0.32%
Bentham Science	Bentham Science, 1, 0.32% Bentham Science 1 publication, 0.32%
Spandidos Publications	Spandidos Publications, 1, 0.32% Spandidos Publications 1 publication, 0.32%
	10 20 30 40 50 60 70

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Koenig P. et al. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape // Science. 2021. Vol. 371. No. 6530.

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Koenig P., Das H., Liu H., Kümmerer B. M., Gohr F. N., Jenster L. M., Schiffelers L. D., Tesfamariam Y. M., Uchima M., Wuerth J. D., Gatterdam K., Ruétalo N., Christensen M. H., Fandrey C. I., Normann S., Tödtmann J. M., Pritzl S., Hanke L., Boos J., Yuan M., Zhu X., Schmid-Burgk J., Kato H., Schindler M., Wilson I. H., Geyer M., Ludwig K. U., Hallberg B. M., Wu N., Schmidt F. I. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape // Science. 2021. Vol. 371. No. 6530.

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TY - JOUR

DO - 10.1126/science.abe6230

UR - https://doi.org/10.1126/science.abe6230

TI - Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

T2 - Science

AU - Koenig, Paul-Albert

AU - Das, Hrishikesh

AU - Liu, Hejun

AU - Kümmerer, Beate M

AU - Gohr, Florian N

AU - Jenster, Lea Marie

AU - Schiffelers, Lisa Dj

AU - Tesfamariam, Yonas M

AU - Uchima, Miki

AU - Wuerth, Jennifer Deborah

AU - Gatterdam, Karl

AU - Ruétalo, Natalia

AU - Christensen, Maria H.

AU - Fandrey, Caroline I

AU - Normann, Sabine

AU - Tödtmann, Jan Mp

AU - Pritzl, Steffen

AU - Hanke, Leo

AU - Boos, Jannik

AU - Yuan, Meng

AU - Zhu, Xue-Yong

AU - Schmid-Burgk, J.

AU - Kato, Hiroki

AU - Schindler, Michael

AU - Wilson, I. H.

AU - Geyer, Matthias

AU - Ludwig, Kerstin U.

AU - Hallberg, B. Martin

AU - Wu, Nicholas

AU - Schmidt, Florian I.

PY - 2021

DA - 2021/02/12 00:00:00

PB - American Association for the Advancement of Science (AAAS)

IS - 6530

VL - 371

SN - 0036-8075

SN - 1095-9203

ER -

BibTex

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@article{2021_Koenig,

author = {Paul-Albert Koenig and Hrishikesh Das and Hejun Liu and Beate M Kümmerer and Florian N Gohr and Lea Marie Jenster and Lisa Dj Schiffelers and Yonas M Tesfamariam and Miki Uchima and Jennifer Deborah Wuerth and Karl Gatterdam and Natalia Ruétalo and Maria H. Christensen and Caroline I Fandrey and Sabine Normann and Jan Mp Tödtmann and Steffen Pritzl and Leo Hanke and Jannik Boos and Meng Yuan and Xue-Yong Zhu and J. Schmid-Burgk and Hiroki Kato and Michael Schindler and I. H. Wilson and Matthias Geyer and Kerstin U. Ludwig and B. Martin Hallberg and Nicholas Wu and Florian I. Schmidt},

title = {Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape},

journal = {Science},

year = {2021},

volume = {371},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {feb},

url = {https://doi.org/10.1126/science.abe6230},

number = {6530},

doi = {10.1126/science.abe6230}

}

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

Quartile SCImago

Quartile WOS

Impact factor

56.9

ISSN

00368075 (Print)
10959203 (Electronic)