Open Access
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
Тип публикации: Journal Article
Дата публикации: 2021-02-12
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 10.948
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
33436526
Multidisciplinary
Краткое описание
A double punch against SARS-CoV-2
Monoclonal antibodies are an important weapon in the battle against COVID-19. However, these large proteins are difficult to produce in the needed quantities and at low cost. Attention has turned to nanobodies, which are aptly named, single-domain antibodies that are easier to produce and have the potential to be administered by inhalation. Koenig et al. describe four nanobodies that bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prevent infection of cells (see the Perspective by Saelens and Schepens). Structures show that the nanobodies target two distinct epitopes on the SARS-CoV-2 spike protein. Multivalent nanobodies neutralize virus much more potently than single nanobodies, and multivalent nanobodies that bind two epitopes prevent the emergence of viral escape mutants.
Science
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Koenig P. et al. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape // Science. 2021. Vol. 371. No. 6530.
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Koenig P., Das H., Liu H., Kümmerer B. M., Gohr F. N., Jenster L. M., Schiffelers L. D., Tesfamariam Y. M., Uchima M., Wuerth J. D., Gatterdam K., Ruétalo N., Christensen M. H., Fandrey C. I., Normann S., Tödtmann J. M., Pritzl S., Hanke L., Boos J., Yuan M., Zhu X., Schmid-Burgk J., Kato H., Schindler M., Wilson I. H., Geyer M., Ludwig K. U., Hallberg B. M., Wu N., Schmidt F. I. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape // Science. 2021. Vol. 371. No. 6530.
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TY - JOUR
DO - 10.1126/science.abe6230
UR - https://doi.org/10.1126/science.abe6230
TI - Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
T2 - Science
AU - Koenig, Paul-Albert
AU - Das, Hrishikesh
AU - Liu, Hejun
AU - Kümmerer, Beate M
AU - Gohr, Florian N
AU - Jenster, Lea Marie
AU - Schiffelers, Lisa Dj
AU - Tesfamariam, Yonas M
AU - Uchima, Miki
AU - Wuerth, Jennifer Deborah
AU - Gatterdam, Karl
AU - Ruétalo, Natalia
AU - Christensen, Maria H.
AU - Fandrey, Caroline I
AU - Normann, Sabine
AU - Tödtmann, Jan Mp
AU - Pritzl, Steffen
AU - Hanke, Leo
AU - Boos, Jannik
AU - Yuan, Meng
AU - Zhu, Xue-Yong
AU - Schmid-Burgk, J.
AU - Kato, Hiroki
AU - Schindler, Michael
AU - Wilson, I. H.
AU - Geyer, Matthias
AU - Ludwig, Kerstin U.
AU - Hallberg, B. Martin
AU - Wu, Nicholas
AU - Schmidt, Florian I.
PY - 2021
DA - 2021/02/12
PB - American Association for the Advancement of Science (AAAS)
IS - 6530
VL - 371
PMID - 33436526
SN - 0036-8075
SN - 1095-9203
ER -
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@article{2021_Koenig,
author = {Paul-Albert Koenig and Hrishikesh Das and Hejun Liu and Beate M Kümmerer and Florian N Gohr and Lea Marie Jenster and Lisa Dj Schiffelers and Yonas M Tesfamariam and Miki Uchima and Jennifer Deborah Wuerth and Karl Gatterdam and Natalia Ruétalo and Maria H. Christensen and Caroline I Fandrey and Sabine Normann and Jan Mp Tödtmann and Steffen Pritzl and Leo Hanke and Jannik Boos and Meng Yuan and Xue-Yong Zhu and J. Schmid-Burgk and Hiroki Kato and Michael Schindler and I. H. Wilson and Matthias Geyer and Kerstin U. Ludwig and B. Martin Hallberg and Nicholas Wu and Florian I. Schmidt},
title = {Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape},
journal = {Science},
year = {2021},
volume = {371},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {feb},
url = {https://doi.org/10.1126/science.abe6230},
number = {6530},
doi = {10.1126/science.abe6230}
}
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