Science Translational Medicine, volume 13, issue 593

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

Bryan E Jones ¹

P. BROWN-AUGSBURGER ²

Kizzmekia S. Corbett ³

Kathryn Westendorf ⁴

Julian Davies ¹

Thomas P Cujec ¹

Christopher M Wiethoff ²

Jamie L Blackbourne ²

Beverly A. Heinz ²

Denisa Foster ¹

Richard Higgs ²

Deepa Balasubramaniam ¹

LINGSHU WANG ³

Yi Zhang ³

Eun-Sung Yang ³

Roza Bidshahri ⁴

Lucas Kraft ⁴

Yuri Hwang ⁴

Stefanie Žentelis ⁴

Kevin Jepson ⁴

Rodrigo Goya ⁴

Maia A Smith ⁴

Gilbert W Collins ⁴

Samuel J. H. Hinshaw ⁴

Sean A Tycho ⁴

Davide Pellacani ⁴

Ping Xiang ⁴

Krithika Muthuraman ⁴

Solmaz Sobhanifar ⁴

Marissa H Piper ¹

Franz J Triana ¹

Jörg Hendle ¹

Anna Pustilnik ¹

Andrew C. Adams ²

Shawn J Berens ²

Ralph Baric ⁵

David R. Martinez ⁵

Robert W. Cross ⁶

Thomas W. Geisbert ⁶

Viktoriya Borisevich ⁶

Olubukola M. Abiona ³

Hayley M Belli ⁷

Maren De Vries ⁸

Adil Mohamed ⁸

Meike Dittmann ⁸

Marie I Samanovic ⁹

Mark J. Mulligan ⁹

Jory A Goldsmith ¹⁰

Ching Lin Hsieh ¹⁰

Nicole V Johnson ¹⁰

Daniel Wrapp ¹⁰

Jason McLellan ¹⁰

Bryan C Barnhart ⁴

B. Graham ³

John Mascola ³

Carl L. Hansen ⁴

Ester Falconer ⁴

Hide authors affiliations Show authors affiliations: 10 affiliations

Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, USA. |

Eli Lilly and Company, Indianapolis, IN 46225, USA. |

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |

⁴

AbCellera Biologics Inc., Vancouver, BC V5Y0A1, Canada. |

⁵

University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |

⁶

Galveston National Laboratory and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. |

⁷

Department of Population Health, Division of Biostatistics, New York University Grossman School of Medicine, New York, NY 10016, USA. |

⁸

Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA. |

⁹

NYU Langone Vaccine Center, Department of Medicine, Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, NY 10016, USA. |

¹⁰

Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. |

Publication type: Journal Article

Publication date: 2021-05-12

American Association for the Advancement of Science (AAAS)

Journal: Science Translational Medicine

Quartile SCImago

Quartile WOS

Impact factor: 17.1

ISSN: 19466234, 19466242

DOI: 10.1126/scitranslmed.abf1906

Copy DOI

PubMed ID: 33820835

General Medicine

Abstract

LY-CoV555, a SARS-CoV-2 spike protein–specific antibody, neutralizes SARS-CoV-2 and protects the airways of nonhuman primates against infection. A monoclonal for SARS-CoV-2 Among the most promising therapeutic options for individuals with coronavirus disease 2019 (COVID-19) are monoclonal antibodies (mAbs). In this study, Jones et al. identified, characterized, and tested one such mAb, LY-CoV555, in vitro and in vivo. They found that LY-CoV555 bound to the severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) spike protein and prevented its interaction with angiotensin-converting enzyme 2. Prophylactic treatment with LY-CoV555 protected the upper and lower respiratory tracts of nonhuman primates from becoming infected with SARS-CoV-2. Together, these data support the clinical use of LY-CoV555 for treating patients with COVID-19. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics that may bridge widespread vaccination campaigns and offer a treatment solution in populations less responsive to vaccination. Here, we report that high-throughput microfluidic screening of antigen-specific B cells led to the identification of LY-CoV555 (also known as bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with coronavirus disease 2019 (COVID-19). Biochemical, structural, and functional characterization of LY-CoV555 revealed high-affinity binding to the receptor-binding domain, angiotensin-converting enzyme 2 binding inhibition, and potent neutralizing activity. A pharmacokinetic study of LY-CoV555 conducted in cynomolgus monkeys demonstrated a mean half-life of 13 days and a clearance of 0.22 ml hour−1 kg−1, consistent with a typical human therapeutic antibody. In a rhesus macaque challenge model, prophylactic doses as low as 2.5 mg/kg reduced viral replication in the upper and lower respiratory tract in samples collected through study day 6 after viral inoculation. This antibody has entered clinical testing and is being evaluated across a spectrum of COVID-19 indications, including prevention and treatment.

By date By citations

Top-30

Citations by journals

	2 4 6 8 10 12
Cell Reports	Cell Reports, 11, 3.29% Cell Reports 11 publications, 3.29%
Nature Communications	Nature Communications, 10, 2.99% Nature Communications 10 publications, 2.99%
Frontiers in Immunology	Frontiers in Immunology, 9, 2.69% Frontiers in Immunology 9 publications, 2.69%
Nature	Nature, 9, 2.69% Nature 9 publications, 2.69%
Viruses	Viruses, 7, 2.1% Viruses 7 publications, 2.1%
Science	Science, 6, 1.8% Science 6 publications, 1.8%
Antiviral Research	Antiviral Research, 6, 1.8% Antiviral Research 6 publications, 1.8%
Immunity	Immunity, 6, 1.8% Immunity 6 publications, 1.8%
iScience	iScience, 5, 1.5% iScience 5 publications, 1.5%
Cell Host and Microbe	Cell Host and Microbe, 5, 1.5% Cell Host and Microbe 5 publications, 1.5%
Journal of Medical Virology	Journal of Medical Virology, 5, 1.5% Journal of Medical Virology 5 publications, 1.5%
Journal of Biomedical Science	Journal of Biomedical Science, 4, 1.2% Journal of Biomedical Science 4 publications, 1.2%
Cell	Cell, 4, 1.2% Cell 4 publications, 1.2%
Journal of Chemical Information and Modeling	Journal of Chemical Information and Modeling, 4, 1.2% Journal of Chemical Information and Modeling 4 publications, 1.2%
Science Translational Medicine	Science Translational Medicine, 4, 1.2% Science Translational Medicine 4 publications, 1.2%
Microbiology spectrum	Microbiology spectrum, 4, 1.2% Microbiology spectrum 4 publications, 1.2%
PLoS Pathogens	PLoS Pathogens, 3, 0.9% PLoS Pathogens 3 publications, 0.9%
Vaccines	Vaccines, 3, 0.9% Vaccines 3 publications, 0.9%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 0.9% International Journal of Molecular Sciences 3 publications, 0.9%
Nature Medicine	Nature Medicine, 3, 0.9% Nature Medicine 3 publications, 0.9%
Cell Discovery	Cell Discovery, 3, 0.9% Cell Discovery 3 publications, 0.9%
Reviews in Medical Virology	Reviews in Medical Virology, 3, 0.9% Reviews in Medical Virology 3 publications, 0.9%
Journal of Physical Chemistry Letters	Journal of Physical Chemistry Letters, 3, 0.9% Journal of Physical Chemistry Letters 3 publications, 0.9%
mAbs	mAbs, 3, 0.9% mAbs 3 publications, 0.9%
Science immunology	Science immunology, 3, 0.9% Science immunology 3 publications, 0.9%
Journal of Virology	Journal of Virology, 3, 0.9% Journal of Virology 3 publications, 0.9%
Antibodies	Antibodies, 2, 0.6% Antibodies 2 publications, 0.6%
Biomedicines	Biomedicines, 2, 0.6% Biomedicines 2 publications, 0.6%
Infectious Diseases and Therapy	Infectious Diseases and Therapy, 2, 0.6% Infectious Diseases and Therapy 2 publications, 0.6%
	2 4 6 8 10 12

Citations by publishers

	10 20 30 40 50 60 70 80
Elsevier	Elsevier, 73, 21.86% Elsevier 73 publications, 21.86%
Springer Nature	Springer Nature, 62, 18.56% Springer Nature 62 publications, 18.56%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 57, 17.07% Cold Spring Harbor Laboratory 57 publications, 17.07%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 23, 6.89% Multidisciplinary Digital Publishing Institute (MDPI) 23 publications, 6.89%
Wiley	Wiley, 20, 5.99% Wiley 20 publications, 5.99%
Frontiers Media S.A.	Frontiers Media S.A., 14, 4.19% Frontiers Media S.A. 14 publications, 4.19%
American Chemical Society (ACS)	American Chemical Society (ACS), 14, 4.19% American Chemical Society (ACS) 14 publications, 4.19%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 13, 3.89% American Association for the Advancement of Science (AAAS) 13 publications, 3.89%
American Society for Microbiology	American Society for Microbiology, 9, 2.69% American Society for Microbiology 9 publications, 2.69%
Taylor & Francis	Taylor & Francis, 8, 2.4% Taylor & Francis 8 publications, 2.4%
Oxford University Press	Oxford University Press, 7, 2.1% Oxford University Press 7 publications, 2.1%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 5, 1.5% Public Library of Science (PLoS) 5 publications, 1.5%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 0.9% Royal Society of Chemistry (RSC) 3 publications, 0.9%
Pleiades Publishing	Pleiades Publishing, 2, 0.6% Pleiades Publishing 2 publications, 0.6%
SAGE	SAGE, 2, 0.6% SAGE 2 publications, 0.6%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 2, 0.6% American Society for Biochemistry and Molecular Biology 2 publications, 0.6%
American Medical Association (AMA)	American Medical Association (AMA), 2, 0.6% American Medical Association (AMA) 2 publications, 0.6%
American College of Physicians	American College of Physicians, 1, 0.3% American College of Physicians 1 publication, 0.3%
American Society for Clinical Investigation	American Society for Clinical Investigation, 1, 0.3% American Society for Clinical Investigation 1 publication, 0.3%
American Society for Pharmacology and Experimental Therapeutics	American Society for Pharmacology and Experimental Therapeutics, 1, 0.3% American Society for Pharmacology and Experimental Therapeutics 1 publication, 0.3%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.3% Mary Ann Liebert 1 publication, 0.3%
Portland Press	Portland Press, 1, 0.3% Portland Press 1 publication, 0.3%
Biophysical Society of Japan	Biophysical Society of Japan, 1, 0.3% Biophysical Society of Japan 1 publication, 0.3%
EMBO press	EMBO press, 1, 0.3% EMBO press 1 publication, 0.3%
Rockefeller University Press	Rockefeller University Press, 1, 0.3% Rockefeller University Press 1 publication, 0.3%
Annual Reviews	Annual Reviews, 1, 0.3% Annual Reviews 1 publication, 0.3%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 1, 0.3% International Union of Crystallography (IUCr) 1 publication, 0.3%
Acta Naturae Ltd	Acta Naturae Ltd, 1, 0.3% Acta Naturae Ltd 1 publication, 0.3%
European Respiratory Society (ERS)	European Respiratory Society (ERS), 1, 0.3% European Respiratory Society (ERS) 1 publication, 0.3%
	10 20 30 40 50 60 70 80

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST Copy

Jones B. E. et al. The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates // Science Translational Medicine. 2021. Vol. 13. No. 593.

GOST all authors (up to 50) Copy

Jones B. E. et al. The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates // Science Translational Medicine. 2021. Vol. 13. No. 593.

RIS |

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TY - JOUR

DO - 10.1126/scitranslmed.abf1906

UR - https://doi.org/10.1126/scitranslmed.abf1906

TI - The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

T2 - Science Translational Medicine

AU - Jones, Bryan E

AU - BROWN-AUGSBURGER, P.

AU - Corbett, Kizzmekia S.

AU - Westendorf, Kathryn

AU - Davies, Julian

AU - Cujec, Thomas P

AU - Wiethoff, Christopher M

AU - Blackbourne, Jamie L

AU - Heinz, Beverly A.

AU - Higgs, Richard

AU - Balasubramaniam, Deepa

AU - WANG, LINGSHU

AU - Zhang, Yi

AU - Yang, Eun-Sung

AU - Bidshahri, Roza

AU - Kraft, Lucas

AU - Hwang, Yuri

AU - Žentelis, Stefanie

AU - Jepson, Kevin

AU - Goya, Rodrigo

AU - Smith, Maia A

AU - Collins, Gilbert W

AU - Hinshaw, Samuel J. H.

AU - Tycho, Sean A

AU - Pellacani, Davide

AU - Xiang, Ping

AU - Muthuraman, Krithika

AU - Sobhanifar, Solmaz

AU - Piper, Marissa H

AU - Hendle, Jörg

AU - Pustilnik, Anna

AU - Adams, Andrew C.

AU - Berens, Shawn J

AU - Baric, Ralph

AU - Martinez, David R.

AU - Cross, Robert W.

AU - Geisbert, Thomas W.

AU - Borisevich, Viktoriya

AU - Abiona, Olubukola M.

AU - Belli, Hayley M

AU - De Vries, Maren

AU - Dittmann, Meike

AU - Samanovic, Marie I

AU - Mulligan, Mark J.

AU - Goldsmith, Jory A

AU - Hsieh, Ching Lin

AU - Johnson, Nicole V

AU - Wrapp, Daniel

AU - McLellan, Jason

AU - Barnhart, Bryan C

AU - Graham, B.

AU - Mascola, John

AU - Hansen, Carl L.

AU - Falconer, Ester

AU - Foster, Denisa

AU - Triana, Franz J

AU - Mohamed, Adil

PY - 2021

DA - 2021/05/12 00:00:00

PB - American Association for the Advancement of Science (AAAS)

IS - 593

VL - 13

PMID - 33820835

SN - 1946-6234

SN - 1946-6242

ER -

BibTex

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BibTex Copy

@article{2021_Jones,

author = {Bryan E Jones and P. BROWN-AUGSBURGER and Kizzmekia S. Corbett and Kathryn Westendorf and Julian Davies and Thomas P Cujec and Christopher M Wiethoff and Jamie L Blackbourne and Beverly A. Heinz and Richard Higgs and Deepa Balasubramaniam and LINGSHU WANG and Yi Zhang and Eun-Sung Yang and Roza Bidshahri and Lucas Kraft and Yuri Hwang and Stefanie Žentelis and Kevin Jepson and Rodrigo Goya and Maia A Smith and Gilbert W Collins and Samuel J. H. Hinshaw and Sean A Tycho and Davide Pellacani and Ping Xiang and Krithika Muthuraman and Solmaz Sobhanifar and Marissa H Piper and Jörg Hendle and Anna Pustilnik and Andrew C. Adams and Shawn J Berens and Ralph Baric and David R. Martinez and Robert W. Cross and Thomas W. Geisbert and Viktoriya Borisevich and Olubukola M. Abiona and Hayley M Belli and Maren De Vries and Meike Dittmann and Marie I Samanovic and Mark J. Mulligan and Jory A Goldsmith and Ching Lin Hsieh and Nicole V Johnson and Daniel Wrapp and Jason McLellan and Bryan C Barnhart and B. Graham and John Mascola and Carl L. Hansen and Ester Falconer and Denisa Foster and Franz J Triana and Adil Mohamed},

title = {The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates},

journal = {Science Translational Medicine},

year = {2021},

volume = {13},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {may},

url = {https://doi.org/10.1126/scitranslmed.abf1906},

number = {593},

doi = {10.1126/scitranslmed.abf1906}

}

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science Translational Medicine

Quartile SCImago

Quartile WOS

Impact factor

17.1

ISSN

19466234 (Print)
19466242 (Electronic)

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