Open Access
A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding
Stanislav S Terekhov
1, 2
,
Yuliana A Mokrushina
1, 2
,
R S Nazarov
1
,
Alexander Zlobin
1, 3
,
A.O. Zalevsky
1, 3, 4
,
Gleb Bourenkov
5
,
Andrey Golovin
1, 3, 4
,
Alexey Belogurov
1
,
Ilya A. Osterman
2, 6
,
В. А. Митькевич
7
,
Hua Jane Lou
8
,
Benjamin E. Turk
8
,
Matthias Wilmanns
5
,
Ivan Smirnov
1, 2
,
Sidney Altman
9, 10
,
A. G. Gabibov
1, 2, 11
3
4
9
Publication type: Journal Article
Publication date: 2020-06-26
scimago Q1
wos Q1
SJR: 4.324
CiteScore: 19.6
Impact factor: 12.5
ISSN: 23752548
PubMed ID:
32637600
Multidisciplinary
Abstract
Microbial communities are self-controlled by repertoires of lethal agents, the antibiotics. In their turn, these antibiotics are regulated by bioscavengers that are selected in the course of evolution. Kinase-mediated phosphorylation represents one of the general strategies for the emergence of antibiotic resistance. A new subfamily of AmiN-like kinases, isolated from the Siberian bear microbiome, inactivates antibiotic amicoumacin by phosphorylation. The nanomolar substrate affinity defines AmiN as a phosphotransferase with a unique catalytic efficiency proximal to the diffusion limit. Crystallographic analysis and multiscale simulations revealed a catalytically perfect mechanism providing phosphorylation exclusively in the case of a closed active site that counteracts substrate promiscuity. AmiN kinase is a member of the previously unknown subfamily representing the first evidence of a specialized phosphotransferase bioscavenger.
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Metrics
19
Total citations:
19
Citations from 2024:
3
(15.79%)
Cite this
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BibTex |
MLA
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GOST
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Terekhov S. S. et al. A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding // Science advances. 2020. Vol. 6. No. 26. p. eaaz9861.
GOST all authors (up to 50)
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Terekhov S. S., Mokrushina Y. A., Nazarov R. S., Zlobin A., Zalevsky A., Bourenkov G., Golovin A., Belogurov A., Osterman I. A., Kulikova A. A., Митькевич В. А., Lou H. J., Turk B., Wilmanns M., Smirnov I., Altman S., Gabibov A. G. A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding // Science advances. 2020. Vol. 6. No. 26. p. eaaz9861.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/sciadv.aaz9861
UR - https://doi.org/10.1126/sciadv.aaz9861
TI - A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding
T2 - Science advances
AU - Terekhov, Stanislav S
AU - Mokrushina, Yuliana A
AU - Nazarov, R S
AU - Zlobin, Alexander
AU - Zalevsky, A.O.
AU - Bourenkov, Gleb
AU - Golovin, Andrey
AU - Belogurov, Alexey
AU - Osterman, Ilya A.
AU - Kulikova, Alexandra A
AU - Митькевич, В. А.
AU - Lou, Hua Jane
AU - Turk, Benjamin E.
AU - Wilmanns, Matthias
AU - Smirnov, Ivan
AU - Altman, Sidney
AU - Gabibov, A. G.
PY - 2020
DA - 2020/06/26
PB - American Association for the Advancement of Science (AAAS)
SP - eaaz9861
IS - 26
VL - 6
PMID - 32637600
SN - 2375-2548
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Terekhov,
author = {Stanislav S Terekhov and Yuliana A Mokrushina and R S Nazarov and Alexander Zlobin and A.O. Zalevsky and Gleb Bourenkov and Andrey Golovin and Alexey Belogurov and Ilya A. Osterman and Alexandra A Kulikova and В. А. Митькевич and Hua Jane Lou and Benjamin E. Turk and Matthias Wilmanns and Ivan Smirnov and Sidney Altman and A. G. Gabibov},
title = {A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding},
journal = {Science advances},
year = {2020},
volume = {6},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {jun},
url = {https://doi.org/10.1126/sciadv.aaz9861},
number = {26},
pages = {eaaz9861},
doi = {10.1126/sciadv.aaz9861}
}
Cite this
MLA
Copy
Terekhov, Stanislav S., et al. “A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding.” Science advances, vol. 6, no. 26, Jun. 2020, p. eaaz9861. https://doi.org/10.1126/sciadv.aaz9861.