Open Access

American Association for the Advancement of Science (AAAS)

Science advances

, volume 6 , issue 29 , publication number eaba4174

Magnetic levitational bioassembly of 3D tissue construct in space

Vladislav A Parfenov ^{1, 2}

Yusef D. Khesuani ¹

Stanislav V Petrov ¹

Pavel A. Karalkin ^{1, 3}

Elizaveta V Koudan ¹

Elizaveta K Nezhurina ³

Frederico Das Pereira ¹

Alisa A Krokhmal ¹

Anna A Gryadunova ¹

Elena A Bulanova ¹

Igor V Vakhrushev ¹

Igor I Babichenko ⁴

Vladimir Kasyanov ⁵

O. F. Petrov ⁶

M. M. Vasiliev ⁶

Kenneth Brakke ⁷

Sergei I Belousov ⁸

Timofei E Grigoriev ⁸

E. O. Osidak ⁹

Ekaterina I Rossiyskaya ¹⁰

Л. Б. Буравкова ¹¹

Oleg D Kononenko ¹²

Utkan Demirci ¹³

Vladimir Mironov ^{1, 14}

Hide authors affiliations Show authors affiliations: 14 affiliations

Laboratory for Biotechnological Research “3D Bioprinting Solutions”, Moscow, Russia. |

A.A. Baikov Institute of Metallurgy and Material Science, Russian Academy of Sciences, Moscow, Russia. |

P.A. Hertsen Moscow Oncology Research Center, National Medical Research Radiological Center, Moscow, Russia.

National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Herzen Moscow Oncology Research Institute

⁴

Peoples' Friendship University of Russia (RUDN University), Moscow, Russia. |

⁵

Riga Technical University, Riga, Latvia. |

⁶

Joint Institute for High Temperatures, Russian Academy of Sciences, Moscow, Russia. |

⁷

Susquehanna University, Selinsgrove, PA, USA. |

⁸

National Research Center “Kurchatov Institute”, Moscow, Russia. |

⁹

Imtek Ltd., Moscow, Russia. |

¹⁰

Central Research Institute for Machine Building, Korolev, Moscow Region, Russia. |

¹¹

Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. |

¹²

Yu.A. Gagarin Research & Test Cosmonaut Training Center, Star City, Moscow Region, Russia. |

¹³

Canary Center for Early Cancer Detection, Department of Radiology, Stanford University, Palo Alto, CA, USA. |

¹⁴

Institute for Regenerative Medicine, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia. |

Publication type: Journal Article

Publication date: 2020-07-17

American Association for the Advancement of Science (AAAS)

Science advances

scimago Q1

wos Q1

SJR: 4.324

CiteScore: 19.6

Impact factor: 12.5

ISSN: 23752548

DOI: 10.1126/sciadv.aba4174

Copy DOI

PubMed ID: 32743068

Multidisciplinary

Abstract

Magnetic levitation is used for 3D biomanufacturing and biofabrication in space. Magnetic levitational bioassembly of three-dimensional (3D) tissue constructs represents a rapidly emerging scaffold- and label-free approach and alternative conceptual advance in tissue engineering. The magnetic bioassembler has been designed, developed, and certified for life space research. To the best of our knowledge, 3D tissue constructs have been biofabricated for the first time in space under microgravity from tissue spheroids consisting of human chondrocytes. Bioassembly and sequential tissue spheroid fusion presented a good agreement with developed predictive mathematical models and computer simulations. Tissue constructs demonstrated good viability and advanced stages of tissue spheroid fusion process. Thus, our data strongly suggest that scaffold-free formative biofabrication using magnetic fields is a feasible alternative to traditional scaffold-based approaches, hinting a new perspective avenue of research that could significantly advance tissue engineering. Magnetic levitational bioassembly in space can also advance space life science and space regenerative medicine.

Found

5 citations

Koudan Elizaveta

DSc in Biological/biomedical sciences

52 publications, 847 citations

h-index: 16

National University of Science & Technology (MISiS)

Research interests

Cell biology

Regenerative medicine

Tissue Engineering

1 citation

Omelyanchik Aleksandr

PhD in Physics and Mathematics

75 publications, 1 097 citations, 112 reviews

h-index: 18

Immanuel Kant Baltic Federal University

University of Genoa

Institute of Structure of Matter

Research interests

Magnetic nanoparticles

1 citation

Goldberg Margarita

🥼 🤝

PhD in Engineering

109 publications, 868 citations, 6 reviews

h-index: 16

A.A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences

Heterogeneous catalysis

Sintering

Zirconium dioxide

1 citation

Kirsanova Valentina

23 publications, 190 citations

h-index: 9

Herzen Moscow Oncology Research Institute

Tomsk National Research Medical Center of the Russian Academy of Sciences

National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

1 citation

Ligorio Cosimo

27 publications, 712 citations, 6 reviews

h-index: 13

University of Nottingham

University of Manchester

Research interests

Biomaterials

1 citation

Burdukovskii Vitalii

DSc in Chemistry, associate professor

61 publications, 701 citations

h-index: 11

Baikal Institute of Nature Management of the Siberian Branch of the Russian Academy of Sciences

Research interests

"Smart" materials

Additive polymerization

Polymer science

1 citation

Prilepskii Artur

24 publications, 563 citations, 5 reviews

h-index: 13

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GOST Copy

Parfenov V. A. et al. Magnetic levitational bioassembly of 3D tissue construct in space // Science advances. 2020. Vol. 6. No. 29. eaba4174

GOST all authors (up to 50) Copy

Parfenov V. A., Khesuani Y. D., Petrov S. V., Karalkin P., Koudan E. V., Nezhurina E. K., Pereira F. D., Krokhmal A. A., Gryadunova A. A., Bulanova E. A., Vakhrushev I. V., Babichenko I. I., Kasyanov V., Petrov O. F., Vasiliev M. M., Brakke K., Belousov S. I., Grigoriev T. E., Osidak E. O., Rossiyskaya E. I., Буравкова Л. Б., Kononenko O. D., Demirci U., Mironov V. Magnetic levitational bioassembly of 3D tissue construct in space // Science advances. 2020. Vol. 6. No. 29. eaba4174

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/sciadv.aba4174

UR - https://www.science.org/doi/10.1126/sciadv.aba4174

TI - Magnetic levitational bioassembly of 3D tissue construct in space

T2 - Science advances

AU - Parfenov, Vladislav A

AU - Khesuani, Yusef D.

AU - Petrov, Stanislav V

AU - Karalkin, Pavel A.

AU - Koudan, Elizaveta V

AU - Nezhurina, Elizaveta K

AU - Pereira, Frederico Das

AU - Krokhmal, Alisa A

AU - Gryadunova, Anna A

AU - Bulanova, Elena A

AU - Vakhrushev, Igor V

AU - Babichenko, Igor I

AU - Kasyanov, Vladimir

AU - Petrov, O. F.

AU - Vasiliev, M. M.

AU - Brakke, Kenneth

AU - Belousov, Sergei I

AU - Grigoriev, Timofei E

AU - Osidak, E. O.

AU - Rossiyskaya, Ekaterina I

AU - Буравкова, Л. Б.

AU - Kononenko, Oleg D

AU - Demirci, Utkan

AU - Mironov, Vladimir

PY - 2020

DA - 2020/07/17

PB - American Association for the Advancement of Science (AAAS)

IS - 29

VL - 6

PMID - 32743068

SN - 2375-2548

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Parfenov,

author = {Vladislav A Parfenov and Yusef D. Khesuani and Stanislav V Petrov and Pavel A. Karalkin and Elizaveta V Koudan and Elizaveta K Nezhurina and Frederico Das Pereira and Alisa A Krokhmal and Anna A Gryadunova and Elena A Bulanova and Igor V Vakhrushev and Igor I Babichenko and Vladimir Kasyanov and O. F. Petrov and M. M. Vasiliev and Kenneth Brakke and Sergei I Belousov and Timofei E Grigoriev and E. O. Osidak and Ekaterina I Rossiyskaya and Л. Б. Буравкова and Oleg D Kononenko and Utkan Demirci and Vladimir Mironov},

title = {Magnetic levitational bioassembly of 3D tissue construct in space},

journal = {Science advances},

year = {2020},

volume = {6},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {jul},

url = {https://www.science.org/doi/10.1126/sciadv.aba4174},

number = {29},

pages = {eaba4174},

doi = {10.1126/sciadv.aba4174}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science advances

scimago Q1

wos Q1

SJR

4.324

CiteScore

19.6

Impact factor

12.5

ISSN

23752548 (Electronic)

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