Open Access

American Association for the Advancement of Science (AAAS)

Science advances

, volume 6 , issue 50

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L

Michael Dominic Sacco ¹

Chunlong Ma ²

Panagiotis Lagarias ³

Ang Gao ²

Julia Alma Townsend ⁴

Xiangzhi Meng ⁵

Peter Dube ⁵

Xiujun Zhang ¹

Yanmei Hu ²

Naoya Kitamura ²

Brett Hurst ^{6, 7}

Bart Tarbet ^{6, 7}

Michael T. Marty ⁴

Antonios Kolocouris ³

Yan Xiang ⁵

Yu Chen ¹

J. Wang ²

Hide authors affiliations Show authors affiliations: 7 affiliations

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. |

Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA. |

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens 15771, Greece. |

⁴

Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA. |

⁵

Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. |

⁶

Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA. |

⁷

Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA. |

Publication type: Journal Article

Publication date: 2020-12-11

American Association for the Advancement of Science (AAAS)

Science advances

scimago Q1

wos Q1

SJR: 4.324

CiteScore: 19.6

Impact factor: 12.5

ISSN: 23752548

DOI: 10.1126/sciadv.abe0751

Copy DOI

PubMed ID: 33158912

Multidisciplinary

Abstract

X-ray crystal structures of SARS-CoV-2 M ^pro with dual inhibitors provide a new direction for the designing of COVID-19 antivirals.

Found

2 citations

Cohen Seth

PhD, lecturer

411 publications, 34 193 citations, 166 reviews

h-index: 92

University of California, San Diego

Research interests

Bioinorganic Chemistry

Inorganic Chemistry

Medicinal Chemistry

Metal-organic frameworks

Supramolecular chemistry

1 citation

Finko Alexander

PhD in Chemistry, associate professor

49 publications, 231 citations, 2 reviews

h-index: 8

A.V. Topchiev Institute of Petrochemical Synthesis RAS

Lomonosov Moscow State University

1 citation

Arkhipov Sergey

39 publications, 313 citations

h-index: 11

Boreskov Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences

1 citation

Emran Talha

560 publications, 18 854 citations, 7 343 reviews

h-index: 67

Brown University

BGC Trust University Bangladesh

Research interests

Bioinformatics

Immunology

1 citation

Yüce Merve

7 publications, 62 citations

h-index: 4

Istanbul Technical University

1 citation

Olimpio Ricardo

90 publications, 1 680 citations

h-index: 24

Universidade Estadual da Paraiba

Federal University of Paraiba

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GOST |

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GOST Copy

Sacco M. D. et al. Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L // Science advances. 2020. Vol. 6. No. 50.

GOST all authors (up to 50) Copy

Sacco M. D., Ma C., Lagarias P., Gao A., Townsend J. A., Meng X., Dube P., Zhang X., Hu Y., Kitamura N., Hurst B., Tarbet B., Marty M. T., Kolocouris A., Xiang Y., Chen Yu., Wang J. Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L // Science advances. 2020. Vol. 6. No. 50.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/sciadv.abe0751

UR - https://doi.org/10.1126/sciadv.abe0751

TI - Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L

T2 - Science advances

AU - Sacco, Michael Dominic

AU - Ma, Chunlong

AU - Lagarias, Panagiotis

AU - Gao, Ang

AU - Townsend, Julia Alma

AU - Meng, Xiangzhi

AU - Dube, Peter

AU - Zhang, Xiujun

AU - Hu, Yanmei

AU - Kitamura, Naoya

AU - Hurst, Brett

AU - Tarbet, Bart

AU - Marty, Michael T.

AU - Kolocouris, Antonios

AU - Xiang, Yan

AU - Chen, Yu

AU - Wang, J.

PY - 2020

DA - 2020/12/11

PB - American Association for the Advancement of Science (AAAS)

IS - 50

VL - 6

PMID - 33158912

SN - 2375-2548

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Sacco,

author = {Michael Dominic Sacco and Chunlong Ma and Panagiotis Lagarias and Ang Gao and Julia Alma Townsend and Xiangzhi Meng and Peter Dube and Xiujun Zhang and Yanmei Hu and Naoya Kitamura and Brett Hurst and Bart Tarbet and Michael T. Marty and Antonios Kolocouris and Yan Xiang and Yu Chen and J. Wang},

title = {Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L},

journal = {Science advances},

year = {2020},

volume = {6},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {dec},

url = {https://doi.org/10.1126/sciadv.abe0751},

number = {50},

doi = {10.1126/sciadv.abe0751}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science advances

scimago Q1

wos Q1

SJR

4.324

CiteScore

19.6

Impact factor

12.5

ISSN

23752548 (Electronic)

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