Open Access
Open access
Science advances, volume 8, issue 21

E-site drug specificity of the human pathogen Candida albicans ribosome

Zgadzay Yury 1, 2
Wu Cheng 4
Усачев К. 1, 5
Validov Shamil 1, 5
Jenner L. 2
Rogachev Andrey 6, 7
Yusupova Gulnara 2
Sachs M. S. 4
Guskov A. 3, 6
Yusupov Marat 1, 2, 5
Publication typeJournal Article
Publication date2022-05-27
Journal: Science advances
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor13.6
ISSN23752548
Multidisciplinary
Abstract

Candida albicans is a widespread commensal fungus with substantial pathogenic potential and steadily increasing resistance to current antifungal drugs. It is known to be resistant to cycloheximide (CHX) that binds to the E–transfer RNA binding site of the ribosome. Because of lack of structural information, it is neither possible to understand the nature of the resistance nor to develop novel inhibitors. To overcome this issue, we determined the structure of the vacant C. albicans 80 S ribosome at 2.3 angstroms and its complexes with bound inhibitors at resolutions better than 2.9 angstroms using cryo–electron microscopy. Our structures reveal how a change in a conserved amino acid in ribosomal protein eL42 explains CHX resistance in C. albicans and forms a basis for further antifungal drug development.

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GOST Copy
Zgadzay Y. et al. E-site drug specificity of the human pathogen Candida albicans ribosome // Science advances. 2022. Vol. 8. No. 21.
GOST all authors (up to 50) Copy
Zgadzay Y., Kolosova O., Stetsenko A., Wu C., Bruchlen D., Усачев К., Validov S., Jenner L., Rogachev A., Yusupova G., Sachs M. S., Guskov A., Yusupov M. E-site drug specificity of the human pathogen Candida albicans ribosome // Science advances. 2022. Vol. 8. No. 21.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1126/sciadv.abn1062
UR - https://doi.org/10.1126%2Fsciadv.abn1062
TI - E-site drug specificity of the human pathogen Candida albicans ribosome
T2 - Science advances
AU - Zgadzay, Yury
AU - Kolosova, Olga
AU - Stetsenko, Artem
AU - Wu, Cheng
AU - Bruchlen, David
AU - Усачев, К.
AU - Validov, Shamil
AU - Jenner, L.
AU - Yusupova, Gulnara
AU - Sachs, M. S.
AU - Guskov, A.
AU - Yusupov, Marat
AU - Rogachev, Andrey
PY - 2022
DA - 2022/05/27 00:00:00
PB - American Association for the Advancement of Science (AAAS)
IS - 21
VL - 8
PMID - 35613268
SN - 2375-2548
ER -
BibTex
Cite this
BibTex Copy
@article{2022_Zgadzay
author = {Yury Zgadzay and Olga Kolosova and Artem Stetsenko and Cheng Wu and David Bruchlen and К. Усачев and Shamil Validov and L. Jenner and Gulnara Yusupova and M. S. Sachs and A. Guskov and Marat Yusupov and Andrey Rogachev},
title = {E-site drug specificity of the human pathogen Candida albicans ribosome},
journal = {Science advances},
year = {2022},
volume = {8},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {may},
url = {https://doi.org/10.1126%2Fsciadv.abn1062},
number = {21},
doi = {10.1126/sciadv.abn1062}
}
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