E-site drug specificity of the human pathogen Candida albicans ribosome
Candida albicans is a widespread commensal fungus with substantial pathogenic potential and steadily increasing resistance to current antifungal drugs. It is known to be resistant to cycloheximide (CHX) that binds to the E–transfer RNA binding site of the ribosome. Because of lack of structural information, it is neither possible to understand the nature of the resistance nor to develop novel inhibitors. To overcome this issue, we determined the structure of the vacant C. albicans 80 S ribosome at 2.3 angstroms and its complexes with bound inhibitors at resolutions better than 2.9 angstroms using cryo–electron microscopy. Our structures reveal how a change in a conserved amino acid in ribosomal protein eL42 explains CHX resistance in C. albicans and forms a basis for further antifungal drug development.
Citations by journals
1
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eLife
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eLife
1 publication, 11.11%
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ChemistrySelect
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ChemistrySelect
1 publication, 11.11%
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Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy
1 publication, 11.11%
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Biochimie
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Biochimie
1 publication, 11.11%
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Biopolymers and Cell
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Biopolymers and Cell, 1, 11.11%
Biopolymers and Cell
1 publication, 11.11%
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Vestnik Moskovskogo universiteta. Seriya 16. Biologiya
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Vestnik Moskovskogo universiteta. Seriya 16. Biologiya
1 publication, 11.11%
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Chemistry and Biodiversity
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Chemistry and Biodiversity
1 publication, 11.11%
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1
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Citations by publishers
1
2
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Wiley
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Wiley
2 publications, 22.22%
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eLife Sciences Publications
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eLife Sciences Publications
1 publication, 11.11%
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American Society for Microbiology
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American Society for Microbiology
1 publication, 11.11%
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Elsevier
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Elsevier
1 publication, 11.11%
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Naukova Dumka
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Naukova Dumka, 1, 11.11%
Naukova Dumka
1 publication, 11.11%
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Moscow University Press
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Moscow University Press
1 publication, 11.11%
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1
2
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