Open Access

Science, volume 307, issue 5709, pages 538-544

Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics

X. Michalet ^{1, 2, 3, 4}

F F Pinaud ^{1, 2, 3, 4}

L A Bentolila ^{1, 2, 3, 4}

J M Tsay ^{1, 2, 3, 4}

S Doose ^{1, 2, 3, 4}

J. J. Li ^{1, 2, 3, 4}

G. Sundaresan ^{1, 2, 3, 4}

A M Wu ^{1, 2, 3, 4}

S S Gambhir ^{1, 2, 3, 4}

S. Weiss ^{1, 2, 3, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, 700 Westwood Plaza, Los Angeles, CA 90095, USA. |

Department of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive East, Los Angeles, CA 90095, USA. |

Department of Radiology and Bio-X Program, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA 94305, USA. |

⁴

Department of Physiology, David Geffen School of Medicine, University of California, 700 Westwood Plaza, Los Angeles, CA 90095, USA. |

Publication type: Journal Article

Publication date: 2005-01-28

American Association for the Advancement of Science (AAAS)

Journal: Science

Quartile SCImago

Quartile WOS

Impact factor: 56.9

ISSN: 00368075, 10959203

DOI: 10.1126/science.1104274

Copy DOI

PubMed ID: 15681376

Multidisciplinary

Abstract

Research on fluorescent semiconductor nanocrystals (also known as quantum dots or qdots) has evolved over the past two decades from electronic materials science to biological applications. We review current approaches to the synthesis, solubilization, and functionalization of qdots and their applications to cell and animal biology. Recent examples of their experimental use include the observation of diffusion of individual glycine receptors in living neurons and the identification of lymph nodes in live animals by near-infrared emission during surgery. The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.

By date By citations

Top-30

Citations by journals

	20 40 60 80 100 120 140 160 180
Journal of Physical Chemistry C	Journal of Physical Chemistry C, 163, 2.43% Journal of Physical Chemistry C 163 publications, 2.43%
Journal of the American Chemical Society	Journal of the American Chemical Society, 152, 2.26% Journal of the American Chemical Society 152 publications, 2.26%
Nanoscale	Nanoscale, 150, 2.23% Nanoscale 150 publications, 2.23%
ACS Nano	ACS Nano, 127, 1.89% ACS Nano 127 publications, 1.89%
RSC Advances	RSC Advances, 116, 1.73% RSC Advances 116 publications, 1.73%
Analytical Chemistry	Analytical Chemistry, 110, 1.64% Analytical Chemistry 110 publications, 1.64%
Chemical Communications	Chemical Communications, 110, 1.64% Chemical Communications 110 publications, 1.64%
Nano Letters	Nano Letters, 109, 1.62% Nano Letters 109 publications, 1.62%
Small	Small, 106, 1.58% Small 106 publications, 1.58%
ACS applied materials & interfaces	ACS applied materials & interfaces, 103, 1.53% ACS applied materials & interfaces 103 publications, 1.53%
Nanotechnology	Nanotechnology, 102, 1.52% Nanotechnology 102 publications, 1.52%
Angewandte Chemie	Angewandte Chemie, 81, 1.21% Angewandte Chemie 81 publications, 1.21%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 81, 1.21% Angewandte Chemie - International Edition 81 publications, 1.21%
Journal of Materials Chemistry A	Journal of Materials Chemistry A, 81, 1.21% Journal of Materials Chemistry A 81 publications, 1.21%
Langmuir	Langmuir, 78, 1.16% Langmuir 78 publications, 1.16%
Advanced Materials	Advanced Materials, 73, 1.09% Advanced Materials 73 publications, 1.09%
Chemistry of Materials	Chemistry of Materials, 70, 1.04% Chemistry of Materials 70 publications, 1.04%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 65, 0.97% Journal of Materials Chemistry B 65 publications, 0.97%
Biomaterials	Biomaterials, 58, 0.86% Biomaterials 58 publications, 0.86%
The Analyst	The Analyst, 55, 0.82% The Analyst 55 publications, 0.82%
Chemical Reviews	Chemical Reviews, 50, 0.74% Chemical Reviews 50 publications, 0.74%
Biosensors and Bioelectronics	Biosensors and Bioelectronics, 50, 0.74% Biosensors and Bioelectronics 50 publications, 0.74%
Advanced Functional Materials	Advanced Functional Materials, 48, 0.71% Advanced Functional Materials 48 publications, 0.71%
Chemical Society Reviews	Chemical Society Reviews, 48, 0.71% Chemical Society Reviews 48 publications, 0.71%
Scientific Reports	Scientific Reports, 48, 0.71% Scientific Reports 48 publications, 0.71%
Journal of Colloid and Interface Science	Journal of Colloid and Interface Science, 48, 0.71% Journal of Colloid and Interface Science 48 publications, 0.71%
Bioconjugate Chemistry	Bioconjugate Chemistry, 46, 0.69% Bioconjugate Chemistry 46 publications, 0.69%
Journal of Nanoparticle Research	Journal of Nanoparticle Research, 41, 0.61% Journal of Nanoparticle Research 41 publications, 0.61%
Methods in Molecular Biology	Methods in Molecular Biology, 41, 0.61% Methods in Molecular Biology 41 publications, 0.61%
	20 40 60 80 100 120 140 160 180

Citations by publishers

	200 400 600 800 1000 1200 1400
Elsevier	Elsevier, 1318, 19.63% Elsevier 1318 publications, 19.63%
American Chemical Society (ACS)	American Chemical Society (ACS), 1259, 18.75% American Chemical Society (ACS) 1259 publications, 18.75%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 876, 13.05% Royal Society of Chemistry (RSC) 876 publications, 13.05%
Wiley	Wiley, 859, 12.79% Wiley 859 publications, 12.79%
Springer Nature	Springer Nature, 717, 10.68% Springer Nature 717 publications, 10.68%
IOP Publishing	IOP Publishing, 184, 2.74% IOP Publishing 184 publications, 2.74%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 136, 2.03% Multidisciplinary Digital Publishing Institute (MDPI) 136 publications, 2.03%
Taylor & Francis	Taylor & Francis, 114, 1.7% Taylor & Francis 114 publications, 1.7%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 94, 1.4% American Institute of Physics (AIP) 94 publications, 1.4%
Future Medicine	Future Medicine, 49, 0.73% Future Medicine 49 publications, 0.73%
American Physical Society (APS)	American Physical Society (APS), 45, 0.67% American Physical Society (APS) 45 publications, 0.67%
Hindawi Limited	Hindawi Limited, 45, 0.67% Hindawi Limited 45 publications, 0.67%
SPIE	SPIE, 42, 0.63% SPIE 42 publications, 0.63%
IEEE	IEEE, 38, 0.57% IEEE 38 publications, 0.57%
Optical Society of America	Optical Society of America, 36, 0.54% Optical Society of America 36 publications, 0.54%
Pleiades Publishing	Pleiades Publishing, 35, 0.52% Pleiades Publishing 35 publications, 0.52%
Frontiers Media S.A.	Frontiers Media S.A., 33, 0.49% Frontiers Media S.A. 33 publications, 0.49%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 27, 0.4% Public Library of Science (PLoS) 27 publications, 0.4%
SAGE	SAGE, 25, 0.37% SAGE 25 publications, 0.37%
World Scientific	World Scientific, 21, 0.31% World Scientific 21 publications, 0.31%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 21, 0.31% Proceedings of the National Academy of Sciences (PNAS) 21 publications, 0.31%
Trans Tech Publications	Trans Tech Publications, 19, 0.28% Trans Tech Publications 19 publications, 0.28%
Biophysical Society	Biophysical Society, 18, 0.27% Biophysical Society 18 publications, 0.27%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 16, 0.24% Cold Spring Harbor Laboratory 16 publications, 0.24%
Materials Research Society	Materials Research Society, 15, 0.22% Materials Research Society 15 publications, 0.22%
Cambridge University Press	Cambridge University Press, 15, 0.22% Cambridge University Press 15 publications, 0.22%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 15, 0.22% American Association for the Advancement of Science (AAAS) 15 publications, 0.22%
Bentham Science	Bentham Science, 14, 0.21% Bentham Science 14 publications, 0.21%
Annual Reviews	Annual Reviews, 12, 0.18% Annual Reviews 12 publications, 0.18%
	200 400 600 800 1000 1200 1400

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Michalet X. et al. Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics // Science. 2005. Vol. 307. No. 5709. pp. 538-544.

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Michalet X., Pinaud F. F., Bentolila L. A., Tsay J. M., Doose S., Li J. J., Sundaresan G., Wu A. M., Gambhir S. S., Weiss S. Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics // Science. 2005. Vol. 307. No. 5709. pp. 538-544.

RIS |

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TY - JOUR

DO - 10.1126/science.1104274

UR - https://doi.org/10.1126/science.1104274

TI - Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics

T2 - Science

AU - Michalet, X.

AU - Pinaud, F F

AU - Bentolila, L A

AU - Tsay, J M

AU - Doose, S

AU - Li, J. J.

AU - Sundaresan, G.

AU - Wu, A M

AU - Gambhir, S S

AU - Weiss, S.

PY - 2005

DA - 2005/01/28 00:00:00

PB - American Association for the Advancement of Science (AAAS)

SP - 538-544

IS - 5709

VL - 307

PMID - 15681376

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

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@article{2005_Michalet,

author = {X. Michalet and F F Pinaud and L A Bentolila and J M Tsay and S Doose and J. J. Li and G. Sundaresan and A M Wu and S S Gambhir and S. Weiss},

title = {Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics},

journal = {Science},

year = {2005},

volume = {307},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {jan},

url = {https://doi.org/10.1126/science.1104274},

number = {5709},

pages = {538--544},

doi = {10.1126/science.1104274}

}

MLA

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Michalet, X., et al. “Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics.” Science, vol. 307, no. 5709, Jan. 2005, pp. 538-544. https://doi.org/10.1126/science.1104274.

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

Quartile SCImago

Quartile WOS

Impact factor

56.9

ISSN

00368075 (Print)
10959203 (Electronic)