Open Access
Science, volume 307, issue 5709, pages 538-544
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
X. Michalet
1, 2, 3, 4
,
F F Pinaud
1, 2, 3, 4
,
L A Bentolila
1, 2, 3, 4
,
J M Tsay
1, 2, 3, 4
,
S Doose
1, 2, 3, 4
,
J. J. Li
1, 2, 3, 4
,
G. Sundaresan
1, 2, 3, 4
,
A M Wu
1, 2, 3, 4
,
S S Gambhir
1, 2, 3, 4
,
S. Weiss
1, 2, 3, 4
1
Department of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive East, Los Angeles, CA 90095, USA.
|
2
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, 700 Westwood Plaza, Los Angeles, CA 90095, USA.
|
3
Department of Physiology, David Geffen School of Medicine, University of California, 700 Westwood Plaza, Los Angeles, CA 90095, USA.
|
Publication type: Journal Article
Publication date: 2005-01-28
PubMed ID:
15681376
Multidisciplinary
Abstract
Research on fluorescent semiconductor nanocrystals (also known as quantum dots or qdots) has evolved over the past two decades from electronic materials science to biological applications. We review current approaches to the synthesis, solubilization, and functionalization of qdots and their applications to cell and animal biology. Recent examples of their experimental use include the observation of diffusion of individual glycine receptors in living neurons and the identification of lymph nodes in live animals by near-infrared emission during surgery. The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Michalet X. et al. Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics // Science. 2005. Vol. 307. No. 5709. pp. 538-544.
GOST all authors (up to 50)
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Michalet X., Pinaud F. F., Bentolila L. A., Tsay J. M., Doose S., Li J. J., Sundaresan G., Wu A. M., Gambhir S. S., Weiss S. Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics // Science. 2005. Vol. 307. No. 5709. pp. 538-544.
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RIS
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TY - JOUR
DO - 10.1126/science.1104274
UR - https://doi.org/10.1126/science.1104274
TI - Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
T2 - Science
AU - Michalet, X.
AU - Pinaud, F F
AU - Bentolila, L A
AU - Tsay, J M
AU - Doose, S
AU - Li, J. J.
AU - Sundaresan, G.
AU - Wu, A M
AU - Gambhir, S S
AU - Weiss, S.
PY - 2005
DA - 2005/01/28
PB - American Association for the Advancement of Science (AAAS)
SP - 538-544
IS - 5709
VL - 307
PMID - 15681376
SN - 0036-8075
SN - 1095-9203
ER -
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BibTex (up to 50 authors)
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@article{2005_Michalet,
author = {X. Michalet and F F Pinaud and L A Bentolila and J M Tsay and S Doose and J. J. Li and G. Sundaresan and A M Wu and S S Gambhir and S. Weiss},
title = {Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics},
journal = {Science},
year = {2005},
volume = {307},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {jan},
url = {https://doi.org/10.1126/science.1104274},
number = {5709},
pages = {538--544},
doi = {10.1126/science.1104274}
}
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Michalet, X., et al. “Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics.” Science, vol. 307, no. 5709, Jan. 2005, pp. 538-544. https://doi.org/10.1126/science.1104274.