Open Access
Science, volume 309, issue 5742, pages 1868-1871
Toward High-Resolution de Novo Structure Prediction for Small Proteins
Publication type: Journal Article
Publication date: 2005-09-16
Multidisciplinary
Abstract
The prediction of protein structure from amino acid sequence is a grand challenge of computational molecular biology. By using a combination of improved low- and high-resolution conformational sampling methods, improved atomically detailed potential functions that capture the jigsaw puzzle–like packing of protein cores, and high-performance computing, high-resolution structure prediction (<1.5 angstroms) can be achieved for small protein domains (<85 residues). The primary bottleneck to consistent high-resolution prediction appears to be conformational sampling.
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Bradley P., Misura K. M., Baker D. Toward High-Resolution de Novo Structure Prediction for Small Proteins // Science. 2005. Vol. 309. No. 5742. pp. 1868-1871.
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Bradley P., Misura K. M., Baker D. Toward High-Resolution de Novo Structure Prediction for Small Proteins // Science. 2005. Vol. 309. No. 5742. pp. 1868-1871.
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TY - JOUR
DO - 10.1126/science.1113801
UR - https://doi.org/10.1126/science.1113801
TI - Toward High-Resolution de Novo Structure Prediction for Small Proteins
T2 - Science
AU - Bradley, Philip
AU - Misura, Kira M.S.
AU - Baker, David
PY - 2005
DA - 2005/09/16
PB - American Association for the Advancement of Science (AAAS)
SP - 1868-1871
IS - 5742
VL - 309
SN - 0036-8075
SN - 1095-9203
ER -
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BibTex
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@article{2005_Bradley,
author = {Philip Bradley and Kira M.S. Misura and David Baker},
title = {Toward High-Resolution de Novo Structure Prediction for Small Proteins},
journal = {Science},
year = {2005},
volume = {309},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {sep},
url = {https://doi.org/10.1126/science.1113801},
number = {5742},
pages = {1868--1871},
doi = {10.1126/science.1113801}
}
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MLA
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Bradley, Philip, et al. “Toward High-Resolution de Novo Structure Prediction for Small Proteins.” Science, vol. 309, no. 5742, Sep. 2005, pp. 1868-1871. https://doi.org/10.1126/science.1113801.