Enantioselective C-H Crotylation of Primary Alcohols via Hydrohydroxyalkylation of Butadiene
Bonded at the Source
Asymmetric catalysis is a relatively mature field in the laboratory, with a diverse array of techniques available for the selective transformation of organic compounds. However, scaling up these techniques for industrial application remains challenging, in part because many catalysts act best on reagents that have been expensively modified, although this process often generates copious waste.
Zbieg
et al.
(p.
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