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Science

, том 359 , издание 6378 , страницы 935-939

Single-cell bioluminescence imaging of deep tissue in freely moving animals

Satoshi Iwano ¹

Mayu Sugiyama ¹

Hiroshi Hama ¹

A. Watakabe ²

Naomi Hasegawa ²

Takahiro Kuchimaru ³

Kazumasa Z Tanaka ⁴

Megumu Takahashi ⁵

Yoko Ishida ⁵

Junichi Hata ⁶

Satoshi Shimozono ¹

Kana Namiki ¹

Takashi Fukano ¹

Masahiro Kiyama ⁷

Hideyuki Okano ⁶

Shinae Kizaka-Kondoh ³

Thomas J. McHugh ⁴

Tetsuo Yamamori ²

Hiroyuki Hioki ⁵

Shojiro MAKI ⁷

Atsushi Miyawaki ^{1, 8}

Скрыть аффилиации авторов Показать аффилиации авторов: 8 аффилиаций

Laboratory for Cell Function and Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan. |

Laboratory for Molecular Analysis of Higher Brain Function, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan. |

School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan. |

⁴

Laboratory for Circuit and Behavioral Physiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan. |

⁵

Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sakyo-ku, Kyoto 606-8501, Japan. |

⁶

Laboratory for Marmoset Neural Architecture, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan. |

⁷

Graduate School of Informatics and Engineering, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu-city, Tokyo 182-8585, Japan. |

⁸

Biotechnological Optics Research Team, Center for Advanced Photonics, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan. |

Тип публикации: Journal Article

Дата публикации: 2018-02-23

American Association for the Advancement of Science (AAAS)

Science

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CiteScore: 48.4

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ISSN: 00368075, 10959203

DOI: 10.1126/science.aaq1067

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PubMed ID: 29472486

Multidisciplinary

Краткое описание

Improved spy tactics for single cells

Bioluminescence imaging is a tremendous asset to medical research, providing a way to monitor living cells noninvasively within their natural environments. Advances in imaging methods allow researchers to measure tumor growth, visualize developmental processes, and track cell-cell interactions. Yet technical limitations exist, and it is difficult to image deep tissues or detect low cell numbers in vivo. Iwano et al. designed a bioluminescence imaging system that produces brighter emission by up to a factor of 1000 compared with conventional technology (see the Perspective by Nasu and Campbell). Individual tumor cells were successfully visualized in the lungs of mice. Small numbers of striatal neurons were detected in the brains of naturally behaving marmosets. The ability of the substrate to cross the blood-brain barrier should provide important opportunities for neuroscience research.

Science , this issue p. 935 ; see also p. 868

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Iwano S. et al. Single-cell bioluminescence imaging of deep tissue in freely moving animals // Science. 2018. Vol. 359. No. 6378. pp. 935-939.

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Iwano S., Sugiyama M., Hama H., Watakabe A., Hasegawa N., Kuchimaru T., Tanaka K. Z., Takahashi M., Ishida Y., Hata J., Shimozono S., Namiki K., Fukano T., Kiyama M., Okano H., Kizaka-Kondoh S., McHugh T. J., Yamamori T., Hioki H., MAKI S., Miyawaki A. Single-cell bioluminescence imaging of deep tissue in freely moving animals // Science. 2018. Vol. 359. No. 6378. pp. 935-939.

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TY - JOUR

DO - 10.1126/science.aaq1067

UR - https://doi.org/10.1126/science.aaq1067

TI - Single-cell bioluminescence imaging of deep tissue in freely moving animals

T2 - Science

AU - Iwano, Satoshi

AU - Sugiyama, Mayu

AU - Hama, Hiroshi

AU - Watakabe, A.

AU - Hasegawa, Naomi

AU - Kuchimaru, Takahiro

AU - Tanaka, Kazumasa Z

AU - Takahashi, Megumu

AU - Ishida, Yoko

AU - Hata, Junichi

AU - Shimozono, Satoshi

AU - Namiki, Kana

AU - Fukano, Takashi

AU - Kiyama, Masahiro

AU - Okano, Hideyuki

AU - Kizaka-Kondoh, Shinae

AU - McHugh, Thomas J.

AU - Yamamori, Tetsuo

AU - Hioki, Hiroyuki

AU - MAKI, Shojiro

AU - Miyawaki, Atsushi

PY - 2018

DA - 2018/02/23

PB - American Association for the Advancement of Science (AAAS)

SP - 935-939

IS - 6378

VL - 359

PMID - 29472486

SN - 0036-8075

SN - 1095-9203

ER -

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@article{2018_Iwano,

author = {Satoshi Iwano and Mayu Sugiyama and Hiroshi Hama and A. Watakabe and Naomi Hasegawa and Takahiro Kuchimaru and Kazumasa Z Tanaka and Megumu Takahashi and Yoko Ishida and Junichi Hata and Satoshi Shimozono and Kana Namiki and Takashi Fukano and Masahiro Kiyama and Hideyuki Okano and Shinae Kizaka-Kondoh and Thomas J. McHugh and Tetsuo Yamamori and Hiroyuki Hioki and Shojiro MAKI and Atsushi Miyawaki},

title = {Single-cell bioluminescence imaging of deep tissue in freely moving animals},

journal = {Science},

year = {2018},

volume = {359},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {feb},

url = {https://doi.org/10.1126/science.aaq1067},

number = {6378},

pages = {935--939},

doi = {10.1126/science.aaq1067}

}

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Iwano, Satoshi, et al. “Single-cell bioluminescence imaging of deep tissue in freely moving animals.” Science, vol. 359, no. 6378, Feb. 2018, pp. 935-939. https://doi.org/10.1126/science.aaq1067.

Издатель

American Association for the Advancement of Science (AAAS)

Журнал

Science

scimago Q1

wos Q1

БС1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)