Open Access
Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction
2
Department of Process Research and Development, Merck Research Laboratories, Rahway, NJ 07065, USA.
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Publication type: Journal Article
Publication date: 2018-05-25
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
29798879
Multidisciplinary
Abstract
Reduction can make cobalt act precious
Enzymes rely on abundant metals such as iron and nickel to manipulate hydrogen. Chemists, on the other hand, have largely had to rely on precious metals such as platinum and rhodium for the task. Friedfeld et al. now report a simple trick to make cobalt act more like rhodium. Reduction of Co(II) to Co(I) by zinc reinforced binding of phosphine ligands to the metal to facilitate its use in asymmetric hydrogenation of alkenes. The cobalt catalysts tolerated alcohol solvents, unlike their rhodium congeners, and could be applied to a 200-gram-scale reduction at 0.08% loading.
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259
Total citations:
259
Citations from 2025:
23
(8.88%)
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GOST
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Friedfeld M. R. et al. Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction // Science. 2018. Vol. 360. No. 6391. pp. 888-893.
GOST all authors (up to 50)
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Friedfeld M. R., Zhong Hongyu 仲., Ruck R. T., Shevlin M., Chirik P. J. Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction // Science. 2018. Vol. 360. No. 6391. pp. 888-893.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/science.aar6117
UR - https://doi.org/10.1126/science.aar6117
TI - Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction
T2 - Science
AU - Friedfeld, Max R
AU - Zhong Hongyu, 仲红玉
AU - Ruck, Rebecca T
AU - Shevlin, Michael
AU - Chirik, Paul J.
PY - 2018
DA - 2018/05/25
PB - American Association for the Advancement of Science (AAAS)
SP - 888-893
IS - 6391
VL - 360
PMID - 29798879
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Friedfeld,
author = {Max R Friedfeld and 仲红玉 Zhong Hongyu and Rebecca T Ruck and Michael Shevlin and Paul J. Chirik},
title = {Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction},
journal = {Science},
year = {2018},
volume = {360},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {may},
url = {https://doi.org/10.1126/science.aar6117},
number = {6391},
pages = {888--893},
doi = {10.1126/science.aar6117}
}
Cite this
MLA
Copy
Friedfeld, Max R., et al. “Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction.” Science, vol. 360, no. 6391, May. 2018, pp. 888-893. https://doi.org/10.1126/science.aar6117.
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