Open Access

Science

, volume 372 , issue 6538 , pages eabd5687

Mechanism and dynamics of fatty acid photodecarboxylase

Damien Sorigué ¹

Kyprianos Hadjidemetriou ²

Stéphanie Blangy ¹

Guillaume Gotthard ³

A. Bonvalet ⁴

N Coquelle ⁵

P Samire ^{1, 6}

Alexey Aleksandrov ⁴

L. Antonucci ⁴

A Benachir ⁴

Sébastien Boutet ⁷

Martin Byrdin ²

Marco Cammarata ⁸

S. Carbajo ⁷

Stephan Cuiné ¹

R. B. Doak ⁹

L. Foucar ⁹

Alexander Gorel ⁹

M Grünbein ⁹

E. HARTMANN ⁹

Rainer Hienerwadel ¹

Mario Hilpert ⁹

M. Kloos ⁹

T.M. Lane ⁷

B Légeret ¹

Pierre Legrand ¹⁰

Yonghua Li-Beisson ¹

Solène Moulin ¹

Didier Nurizzo ³

Gilles Peltier ¹

G Schiró ²

G. Schirò ²

Robert Shoeman ⁹

M. Sliwa ¹¹

Xavier Solinas ⁴

Bo Zhuang ^{4, 6}

Thomas R. M. Barends ⁹

Jacques-Philippe Colletier ²

Manuel Joffre ⁴

Antoine Royant ^{2, 3}

Catherine Berthomieu ¹

Martin Weik ²

Tatiana Domratcheva ^{9, 12}

Klaus Brettel ⁶

Marten H. Vos ⁴

Ilme Schlichting ⁹

Pascal Arnoux ¹

Pavel Müller ⁶

Fred Beisson ¹

Hide authors affiliations Show authors affiliations: 12 affiliations

Aix-Marseille University, CEA, CNRS, Institute of Biosciences and Biotechnologies, BIAM Cadarache, 13108 Saint-Paul-lez-Durance, France. |

Université Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000 Grenoble, France. |

European Synchrotron Radiation Facility, 38043 Grenoble, France. |

⁴

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.

French Institute of Health and Medical Research

Institut polytechnique de Paris

⁵

Large-Scale Structures Group, Institut Laue Langevin, 38042 Grenoble Cedex 9, France. |

⁶

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. |

⁷

Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA. |

⁸

Department of Physics, UMR UR1-CNRS 6251, University of Rennes 1, F-Rennes, France. |

⁹

Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany. |

¹⁰

Synchrotron SOLEIL. L’Orme des Merisiers Saint-Aubin, BP 48, 91192 Gif-sur-Yvette, France. |

¹¹

Univ. Lille, CNRS, UMR 8516, LASIRE, LAboratoire de Spectroscopie pour les Interactions, la Réactivité et l’Environnement, 59000 Lille, France. |

¹²

Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia. |

Publication type: Journal Article

Publication date: 2021-04-09

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.abd5687

Copy DOI

PubMed ID: 33833098

Multidisciplinary

Abstract

Light makes light work of fatty acids

Photosynthetic organisms are notable for their ability to capture light energy and use it to power biosynthesis. Some algae have gone a step beyond photosynthesis and can use light to initiate enzymatic photodecarboxylation of fatty acids, producing long-chain hydrocarbons. To understand this transformation, Sorigué et al. brought to bear an array of structural, computational, and spectroscopic techniques and fully characterized the catalytic cycle of the enzyme. These experiments are consistent with a mechanism starting with electron transfer from the fatty acid to a photoexcited oxidized flavin cofactor. Decarboxylation yields an alkyl radical, which is then reduced by back electron transfer and protonation rather than hydrogen atom transfer. The wealth of experimental data explains how algae harness light energy to produce alka(e)nes and provides an appealing model system for understanding enzyme-catalyzed photochemistry more generally.

Science , this issue p. eabd5687

Found

1 citation

Wohlgemuth Roland

PhD in Chemistry, professor

65 publications, 1 607 citations, 187 reviews

h-index: 18

Lodz University of Technology

Industrial biotechnology

Metabolomics

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Sorigué D. et al. Mechanism and dynamics of fatty acid photodecarboxylase // Science. 2021. Vol. 372. No. 6538. p. eabd5687.

GOST all authors (up to 50) Copy

Sorigué D. et al. Mechanism and dynamics of fatty acid photodecarboxylase // Science. 2021. Vol. 372. No. 6538. p. eabd5687.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.abd5687

UR - https://www.science.org/doi/10.1126/science.abd5687

TI - Mechanism and dynamics of fatty acid photodecarboxylase

T2 - Science

AU - Sorigué, Damien

AU - Hadjidemetriou, Kyprianos

AU - Blangy, Stéphanie

AU - Gotthard, Guillaume

AU - Bonvalet, A.

AU - Coquelle, N

AU - Samire, P

AU - Aleksandrov, Alexey

AU - Antonucci, L.

AU - Benachir, A

AU - Boutet, Sébastien

AU - Byrdin, Martin

AU - Cammarata, Marco

AU - Carbajo, S.

AU - Cuiné, Stephan

AU - Doak, R. B.

AU - Foucar, L.

AU - Gorel, Alexander

AU - Grünbein, M

AU - HARTMANN, E.

AU - Hienerwadel, Rainer

AU - Hilpert, Mario

AU - Kloos, M.

AU - Lane, T.M.

AU - Légeret, B

AU - Legrand, Pierre

AU - Li-Beisson, Yonghua

AU - Moulin, Solène

AU - Nurizzo, Didier

AU - Peltier, Gilles

AU - Schiró, G

AU - Schirò, G.

AU - Shoeman, Robert

AU - Sliwa, M.

AU - Solinas, Xavier

AU - Zhuang, Bo

AU - Barends, Thomas R. M.

AU - Colletier, Jacques-Philippe

AU - Joffre, Manuel

AU - Royant, Antoine

AU - Berthomieu, Catherine

AU - Weik, Martin

AU - Domratcheva, Tatiana

AU - Brettel, Klaus

AU - Vos, Marten H.

AU - Schlichting, Ilme

AU - Arnoux, Pascal

AU - Müller, Pavel

AU - Beisson, Fred

PY - 2021

DA - 2021/04/09

PB - American Association for the Advancement of Science (AAAS)

SP - eabd5687

IS - 6538

VL - 372

PMID - 33833098

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Sorigué,

author = {Damien Sorigué and Kyprianos Hadjidemetriou and Stéphanie Blangy and Guillaume Gotthard and A. Bonvalet and N Coquelle and P Samire and Alexey Aleksandrov and L. Antonucci and A Benachir and Sébastien Boutet and Martin Byrdin and Marco Cammarata and S. Carbajo and Stephan Cuiné and R. B. Doak and L. Foucar and Alexander Gorel and M Grünbein and E. HARTMANN and Rainer Hienerwadel and Mario Hilpert and M. Kloos and T.M. Lane and B Légeret and Pierre Legrand and Yonghua Li-Beisson and Solène Moulin and Didier Nurizzo and Gilles Peltier and G Schiró and G. Schirò and Robert Shoeman and M. Sliwa and Xavier Solinas and Bo Zhuang and Thomas R. M. Barends and Jacques-Philippe Colletier and Manuel Joffre and Antoine Royant and Catherine Berthomieu and Martin Weik and Tatiana Domratcheva and Klaus Brettel and Marten H. Vos and Ilme Schlichting and Pascal Arnoux and Pavel Müller and Fred Beisson and others},

title = {Mechanism and dynamics of fatty acid photodecarboxylase},

journal = {Science},

year = {2021},

volume = {372},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {apr},

url = {https://www.science.org/doi/10.1126/science.abd5687},

number = {6538},

pages = {eabd5687},

doi = {10.1126/science.abd5687}

}

MLA

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MLA Copy

Sorigué, Damien, et al. “Mechanism and dynamics of fatty acid photodecarboxylase.” Science, vol. 372, no. 6538, Apr. 2021, p. eabd5687. https://www.science.org/doi/10.1126/science.abd5687.

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)

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