Open Access

Science

, volume 373 , issue 6556

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Lingshu Wang ¹

Tongqing Zhou ¹

Yi Zhang ¹

Eun-Sung Yang ¹

Chaim A Schramm ¹

Wei Shi ¹

Amarendra Pegu ¹

Olamide K Oloniniyi ¹

Amy R. Henry ¹

Samuel N. Darko ¹

Sandeep Narpala ¹

Christian Hatcher ¹

David G. Martinez ^{2, 3}

Yaroslav Tsybovsky ⁴

Emily Phung ¹

Olubukola M. Abiona ¹

Avan Antia ¹

Evan M. Cale ¹

Lauren Chang ¹

Misook Choe ¹

Kizzmekia S. Corbett ¹

Rachel L Davis ¹

Anthony T. DiPiazza ¹

Ingelise J. Gordon ¹

Sabrina Helmold Hait ¹

Tandile Hermanus ^{5, 6}

Prudence Kgagudi ^{5, 6}

Farida Laboune ¹

Kwanyee Leung ¹

Tracy Liu ¹

Rosemarie Mason ¹

Alexandra F Nazzari ¹

Laura Novik ¹

Sarah O’Connell ¹

Sijy O'Dell ¹

Adam S Olia ¹

Stephen P. Schmidt ¹

Tyler Stephens ⁴

Christopher D Stringham ¹

Chloe Adrienna Talana ¹

I-Ting Teng ¹

John A Wagner ¹

Alicia Widge ¹

Baoshan Zhang ¹

Mario Roederer ¹

Julie E. Ledgerwood ¹

Tracy J. Ruckwardt ¹

Martin R. Gaudinski ¹

Penny Moore ^{5, 6}

N. Doria-Rose ¹

Ralph Baric ^{2, 3}

B. Graham ¹

Adrian B. McDermott ¹

Daniel C. Douek ¹

Peter D. Kwong ¹

John Mascola ¹

Nancy J Sullivan ¹

John Misasi ¹

Hide authors affiliations Show authors affiliations: 6 affiliations

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |

Department of Epidemiology, UNC Chapel Hill School of Public Health, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. |

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. |

⁴

Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. |

⁵

National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa. |

⁶

SAMRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

University of the Witwatersrand

South African Medical Research Council

Publication type: Journal Article

Publication date: 2021-08-13

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.abh1766

Copy DOI

PubMed ID: 34210892

Multidisciplinary

Abstract

Defenses against SARS-CoV-2 variants

Our key defense against the COVID-19 pandemic is neutralizing antibodies against the SARS-CoV-2 virus elicited by natural infection or vaccination. Recent emerging viral variants have raised concern because of their potential to escape antibody neutralization. Wang et al . identified four antibodies from early-outbreak convalescent donors that are potent against 23 variants, including variants of concern, and characterized their binding to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yuan et al . examined the impact of emerging mutations in the receptor-binding domain of the spike protein on binding to the host receptor ACE2 and to a range of antibodies. These studies may be helpful for developing more broadly effective vaccines and therapeutic antibodies. —VV

Found

1 citation

Junhua Pan

22 publications, 1 452 citations, 3 reviews

h-index: 14

Hubei University of Technology

Harvard University

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GOST Copy

Wang L. et al. Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants // Science. 2021. Vol. 373. No. 6556.

GOST all authors (up to 50) Copy

Wang L. et al. Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants // Science. 2021. Vol. 373. No. 6556.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/science.abh1766

UR - https://doi.org/10.1126/science.abh1766

TI - Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

T2 - Science

AU - Wang, Lingshu

AU - Zhou, Tongqing

AU - Zhang, Yi

AU - Yang, Eun-Sung

AU - Schramm, Chaim A

AU - Shi, Wei

AU - Pegu, Amarendra

AU - Oloniniyi, Olamide K

AU - Henry, Amy R.

AU - Darko, Samuel N.

AU - Narpala, Sandeep

AU - Hatcher, Christian

AU - Martinez, David G.

AU - Tsybovsky, Yaroslav

AU - Phung, Emily

AU - Abiona, Olubukola M.

AU - Antia, Avan

AU - Cale, Evan M.

AU - Chang, Lauren

AU - Choe, Misook

AU - Corbett, Kizzmekia S.

AU - Davis, Rachel L

AU - DiPiazza, Anthony T.

AU - Gordon, Ingelise J.

AU - Helmold Hait, Sabrina

AU - Hermanus, Tandile

AU - Kgagudi, Prudence

AU - Laboune, Farida

AU - Leung, Kwanyee

AU - Liu, Tracy

AU - Mason, Rosemarie

AU - Nazzari, Alexandra F

AU - Novik, Laura

AU - O’Connell, Sarah

AU - O'Dell, Sijy

AU - Olia, Adam S

AU - Schmidt, Stephen P.

AU - Stephens, Tyler

AU - Stringham, Christopher D

AU - Talana, Chloe Adrienna

AU - Teng, I-Ting

AU - Wagner, John A

AU - Widge, Alicia

AU - Zhang, Baoshan

AU - Roederer, Mario

AU - Ledgerwood, Julie E.

AU - Ruckwardt, Tracy J.

AU - Gaudinski, Martin R.

AU - Moore, Penny

AU - Doria-Rose, N.

AU - Baric, Ralph

AU - Graham, B.

AU - McDermott, Adrian B.

AU - Douek, Daniel C.

AU - Kwong, Peter D.

AU - Mascola, John

AU - Sullivan, Nancy J

AU - Misasi, John

PY - 2021

DA - 2021/08/13

PB - American Association for the Advancement of Science (AAAS)

IS - 6556

VL - 373

PMID - 34210892

SN - 0036-8075

SN - 1095-9203

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Wang,

author = {Lingshu Wang and Tongqing Zhou and Yi Zhang and Eun-Sung Yang and Chaim A Schramm and Wei Shi and Amarendra Pegu and Olamide K Oloniniyi and Amy R. Henry and Samuel N. Darko and Sandeep Narpala and Christian Hatcher and David G. Martinez and Yaroslav Tsybovsky and Emily Phung and Olubukola M. Abiona and Avan Antia and Evan M. Cale and Lauren Chang and Misook Choe and Kizzmekia S. Corbett and Rachel L Davis and Anthony T. DiPiazza and Ingelise J. Gordon and Sabrina Helmold Hait and Tandile Hermanus and Prudence Kgagudi and Farida Laboune and Kwanyee Leung and Tracy Liu and Rosemarie Mason and Alexandra F Nazzari and Laura Novik and Sarah O’Connell and Sijy O'Dell and Adam S Olia and Stephen P. Schmidt and Tyler Stephens and Christopher D Stringham and Chloe Adrienna Talana and I-Ting Teng and John A Wagner and Alicia Widge and Baoshan Zhang and Mario Roederer and Julie E. Ledgerwood and Tracy J. Ruckwardt and Martin R. Gaudinski and Penny Moore and N. Doria-Rose and others},

title = {Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants},

journal = {Science},

year = {2021},

volume = {373},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {aug},

url = {https://doi.org/10.1126/science.abh1766},

number = {6556},

doi = {10.1126/science.abh1766}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)

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