Antimicrobial Agents and Chemotherapy, volume 65, issue 5

Nybomycin inhibits both fluoroquinolone-sensitive and fluoroquinolone-resistant escherichia coli DNA gyrase

Dmitrii I Shiriaev ¹

Alina A. Sofronova ²

Ekaterina A Berdnikovich ²

Dmitrii A. Lukianov ³

Ekaterina S. Komarova ^{2, 4}

Valeriya I Marina ^{1, 5}

Yuliya V Zakalyukina ⁶

Mikhail V Biryukov ⁵

Tinashe P Maviza ³

Yan A Ivanenkov ^{7, 8}

Petr V. Sergiev ^{1, 3, 4, 9}

Ilya A Osterman ^{1, 3}

Olga A. Dontsova ^{1, 3, 9, 10}

Show full list: 13 authors

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Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia |

Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia |

Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia |

⁴

Institute of Functional Genomics, Lomonosov Moscow State University, Moscow, Russia |

⁵

Department of Biology, Lomonosov Moscow State University, Moscow, Russia |

⁶

Department of Soil Science, Lomonosov Moscow State University, Moscow, Russia |

⁷

Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia

⁸

The Federal State Unitary Enterprise Dukhov Automatics Research Institute, Moscow, Russia |

⁹

Belozersky Institute of Physico-chemical Biology, Lomonosov Moscow State University, Moscow, Russia |

¹⁰

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia |

Publication type: Journal Article

Publication date: 2021-04-19

American Society for Microbiology

Journal: Antimicrobial Agents and Chemotherapy

scimago Q1

wos Q1

SJR: 1.357

CiteScore: 10.0

Impact factor: 4.1

ISSN: 00664804, 10986596

DOI: 10.1128/AAC.00777-20

Copy DOI

PubMed ID: 33593838

Pharmacology

Infectious Diseases

Pharmacology (medical)

Abstract

Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are targets of many antibiotics, including fluoroquinolones (FQs). Unfortunately, a number of bacterial species easily acquire resistance to FQs by mutations in either DNA gyrase or topoisomerase IV genes.

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Publisher

American Society for Microbiology

Journal

Antimicrobial Agents and Chemotherapy

scimago Q1

wos Q1

SJR

1.357

CiteScore

10.0

Impact factor

4.1

ISSN

00664804 (Print)

10986596 (Electronic)

Labs

Laboratory of Nucleoprotein Chemistry, Department of Chemistry of Natural Compounds, Faculty of Chemistry

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Nybomycin inhibits both fluoroquinolone-sensitive and fluoroquinolone-resistant escherichia coli DNA gyrase

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