Infection and Immunity, volume 88, issue 7

Staphylococcus aureus Osteomyelitis: Bone, Bugs, and Surgery

Kenneth L. Urish ^{1, 2, 3, 4}

James E. Cassat ^{5, 6, 7, 8, 9}

Arthritis and Arthroplasty Design Group, The Bone and Joint Center, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA |

Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA |

⁴

Department of Bioengineering, and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA |

⁵

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA |

⁶

Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA |

⁷

Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA |

⁸

Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Vanderbilt University Medical Center, Nashville, Tennessee, USA |

⁹

Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA |

Publication type: Journal Article

Publication date: 2020-06-22

American Society for Microbiology

Journal: Infection and Immunity

scimago Q1

SJR: 1.042

CiteScore: 6.0

Impact factor: 2.9

ISSN: 00199567, 10985522

DOI: 10.1128/iai.00932-19

Copy DOI

PubMed ID: 32094258

Microbiology

Infectious Diseases

Immunology

Parasitology

Abstract

Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial pathogens into the skeleton. Bacterial osteomyelitis is notoriously difficult to treat, in part because of the widespread antimicrobial resistance in the preeminent etiologic agent, the Gram-positive bacterium Staphylococcus aureus . Bacterial osteomyelitis triggers pathological bone remodeling, which in turn leads to sequestration of infectious foci from innate immune effectors and systemically delivered antimicrobials.

Found

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