Antimicrobial Agents and Chemotherapy

, volume 56 , issue 2 , pages 1090-1092

In Vivo Activity of Aryl Ozonides against Schistosoma Species

Jennifer Keiser ^{1, 2}

Katrin Ingram ^{1, 2}

Mireille Vargas ^{1, 2}

JACQUES CHOLLET ^{1, 2}

Xiaofang Wang ³

Yuxiang Dong ³

Jonathan L Vennerstrom ³

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health institute, Basel, Switzerland |

University of Basel, Basel, Switzerland |

University of Nebraska Medical Center, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska, USA |

Publication type: Journal Article

Publication date: 2012-02-03

American Society for Microbiology

Antimicrobial Agents and Chemotherapy

scimago Q1

wos Q1

SJR: 1.431

CiteScore: 8.4

Impact factor: 4.5

ISSN: 00664804, 10986596

DOI: 10.1128/AAC.05371-11

Copy DOI

PubMed ID: 22106214

Pharmacology

Infectious Diseases

Pharmacology (medical)

Abstract

ABSTRACT We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P < 0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.

Found

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GOST |

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GOST Copy

Keiser J. et al. In Vivo Activity of Aryl Ozonides against Schistosoma Species // Antimicrobial Agents and Chemotherapy. 2012. Vol. 56. No. 2. pp. 1090-1092.

GOST all authors (up to 50) Copy

Keiser J., Ingram K., Vargas M., CHOLLET J., Wang X., Dong Y., Vennerstrom J. L. In Vivo Activity of Aryl Ozonides against Schistosoma Species // Antimicrobial Agents and Chemotherapy. 2012. Vol. 56. No. 2. pp. 1090-1092.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1128/AAC.05371-11

UR - https://doi.org/10.1128/AAC.05371-11

TI - In Vivo Activity of Aryl Ozonides against Schistosoma Species

T2 - Antimicrobial Agents and Chemotherapy

AU - Keiser, Jennifer

AU - Ingram, Katrin

AU - Vargas, Mireille

AU - CHOLLET, JACQUES

AU - Wang, Xiaofang

AU - Dong, Yuxiang

AU - Vennerstrom, Jonathan L

PY - 2012

DA - 2012/02/03

PB - American Society for Microbiology

SP - 1090-1092

IS - 2

VL - 56

PMID - 22106214

SN - 0066-4804

SN - 1098-6596

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2012_Keiser,

author = {Jennifer Keiser and Katrin Ingram and Mireille Vargas and JACQUES CHOLLET and Xiaofang Wang and Yuxiang Dong and Jonathan L Vennerstrom},

title = {In Vivo Activity of Aryl Ozonides against Schistosoma Species},

journal = {Antimicrobial Agents and Chemotherapy},

year = {2012},

volume = {56},

publisher = {American Society for Microbiology},

month = {feb},

url = {https://doi.org/10.1128/AAC.05371-11},

number = {2},

pages = {1090--1092},

doi = {10.1128/AAC.05371-11}

}

MLA

Cite this

MLA Copy

Keiser, Jennifer, et al. “In Vivo Activity of Aryl Ozonides against Schistosoma Species.” Antimicrobial Agents and Chemotherapy, vol. 56, no. 2, Feb. 2012, pp. 1090-1092. https://doi.org/10.1128/AAC.05371-11.

Publisher

American Society for Microbiology

Journal

Antimicrobial Agents and Chemotherapy

scimago Q1

wos Q1

SJR

1.431

CiteScore

8.4

Impact factor

4.5

ISSN

00664804 (Print)

10986596 (Electronic)