In Vivo Activity of Aryl Ozonides against Schistosoma Species
Тип публикации: Journal Article
Дата публикации: 2012-02-03
scimago Q1
wos Q1
БС1
SJR: 1.431
CiteScore: 8.4
Impact factor: 4.5
ISSN: 00664804, 10986596
PubMed ID:
22106214
Pharmacology
Infectious Diseases
Pharmacology (medical)
Краткое описание
ABSTRACT We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P < 0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.
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ГОСТ
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Keiser J. et al. In Vivo Activity of Aryl Ozonides against Schistosoma Species // Antimicrobial Agents and Chemotherapy. 2012. Vol. 56. No. 2. pp. 1090-1092.
ГОСТ со всеми авторами (до 50)
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Keiser J., Ingram K., Vargas M., CHOLLET J., Wang X., Dong Y., Vennerstrom J. L. In Vivo Activity of Aryl Ozonides against Schistosoma Species // Antimicrobial Agents and Chemotherapy. 2012. Vol. 56. No. 2. pp. 1090-1092.
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TY - JOUR
DO - 10.1128/AAC.05371-11
UR - https://doi.org/10.1128/AAC.05371-11
TI - In Vivo Activity of Aryl Ozonides against Schistosoma Species
T2 - Antimicrobial Agents and Chemotherapy
AU - Keiser, Jennifer
AU - Ingram, Katrin
AU - Vargas, Mireille
AU - CHOLLET, JACQUES
AU - Wang, Xiaofang
AU - Dong, Yuxiang
AU - Vennerstrom, Jonathan L
PY - 2012
DA - 2012/02/03
PB - American Society for Microbiology
SP - 1090-1092
IS - 2
VL - 56
PMID - 22106214
SN - 0066-4804
SN - 1098-6596
ER -
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BibTex (до 50 авторов)
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@article{2012_Keiser,
author = {Jennifer Keiser and Katrin Ingram and Mireille Vargas and JACQUES CHOLLET and Xiaofang Wang and Yuxiang Dong and Jonathan L Vennerstrom},
title = {In Vivo Activity of Aryl Ozonides against Schistosoma Species},
journal = {Antimicrobial Agents and Chemotherapy},
year = {2012},
volume = {56},
publisher = {American Society for Microbiology},
month = {feb},
url = {https://doi.org/10.1128/AAC.05371-11},
number = {2},
pages = {1090--1092},
doi = {10.1128/AAC.05371-11}
}
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MLA
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Keiser, Jennifer, et al. “In Vivo Activity of Aryl Ozonides against Schistosoma Species.” Antimicrobial Agents and Chemotherapy, vol. 56, no. 2, Feb. 2012, pp. 1090-1092. https://doi.org/10.1128/AAC.05371-11.