A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin
Nikola Ojkic
1
,
Elin Lilja
1
,
Susana Direito
1
,
Angela Dawson
1
,
Rosalind J. Allen
1, 2
,
Bartlomiej Waclaw
1, 2
2
Centre for Synthetic and Systems Biology, Edinburgh, United Kingdom
|
Publication type: Journal Article
Publication date: 2020-08-20
scimago Q1
wos Q1
SJR: 1.431
CiteScore: 8.4
Impact factor: 4.5
ISSN: 00664804, 10986596
PubMed ID:
32601161
Pharmacology
Infectious Diseases
Pharmacology (medical)
Abstract
Fluoroquinolones, antibiotics that cause DNA damage by inhibiting DNA topoisomerases, are clinically important, but their mechanism of action is not yet fully understood. In particular, the dynamical response of bacterial cells to fluoroquinolone exposure has hardly been investigated, although the SOS response, triggered by DNA damage, is often thought to play a key role. Here, we investigated the growth inhibition of the bacterium
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Metrics
54
Total citations:
54
Citations from 2025:
18
(33.33%)
Cite this
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RIS |
BibTex
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GOST
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Ojkic N. et al. A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin // Antimicrobial Agents and Chemotherapy. 2020. Vol. 64. No. 9.
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Ojkic N., Lilja E., Direito S., Dawson A., Allen R. J., Waclaw B. A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin // Antimicrobial Agents and Chemotherapy. 2020. Vol. 64. No. 9.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1128/aac.02487-19
UR - https://doi.org/10.1128/aac.02487-19
TI - A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin
T2 - Antimicrobial Agents and Chemotherapy
AU - Ojkic, Nikola
AU - Lilja, Elin
AU - Direito, Susana
AU - Dawson, Angela
AU - Allen, Rosalind J.
AU - Waclaw, Bartlomiej
PY - 2020
DA - 2020/08/20
PB - American Society for Microbiology
IS - 9
VL - 64
PMID - 32601161
SN - 0066-4804
SN - 1098-6596
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Ojkic,
author = {Nikola Ojkic and Elin Lilja and Susana Direito and Angela Dawson and Rosalind J. Allen and Bartlomiej Waclaw},
title = {A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin},
journal = {Antimicrobial Agents and Chemotherapy},
year = {2020},
volume = {64},
publisher = {American Society for Microbiology},
month = {aug},
url = {https://doi.org/10.1128/aac.02487-19},
number = {9},
doi = {10.1128/aac.02487-19}
}