Biochemistry (Moscow), volume 84, issue 7, pages 695-710
The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells
Publication type: Journal Article
Publication date: 2019-07-13
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
This review focuses on the structure and molecular action mechanisms of chimeric antigen receptors (CARs) and major aspects of the manufacturing and clinical application of products for the CAR-T (CAR-modified T lymphocyte) therapy of hematological and solid tumors with special emphasis on the strategies for combined use of CAR-T therapy with immuno-oncological monoclonal antibodies (checkpoint inhibitors) and cytokines to boost survival, persistence, and anti-tumor efficacy of CAR-T therapy. The review also summarizes preclinical and clinical data on the additive effects of the combined use of CAR-T therapy with interleukins and monoclonal antibodies targeting immune checkpoints.
Citations by journals
|
1
|
|
|
Frontiers in Immunology
|
Frontiers in Immunology
1 publication, 25%
|
|
Biochemical Pharmacology
|
Biochemical Pharmacology
1 publication, 25%
|
|
Biochemistry (Moscow)
|
Biochemistry (Moscow)
1 publication, 25%
|
|
Gastroenterology Report
|
Gastroenterology Report
1 publication, 25%
|
|
1
|
Citations by publishers
|
1
|
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 25%
|
|
Elsevier
|
Elsevier
1 publication, 25%
|
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 25%
|
|
Oxford University Press
|
Oxford University Press
1 publication, 25%
|
|
1
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022,2023],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[2,0,0,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["50",0,0,"25","25"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Frontiers in Immunology","Biochemical Pharmacology","Biochemistry (Moscow)","Gastroenterology Report"],"ids":[1699,20448,2119,19675],"codes":[0,0,0,0],"imageUrls":["\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[25,25,25,25],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Frontiers Media S.A.","Elsevier","Pleiades Publishing","Oxford University Press"],"ids":[208,17,101,19],"codes":[0,0,0,0],"imageUrls":["\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[25,25,25,25],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Gershovich P. M. et al. The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells // Biochemistry (Moscow). 2019. Vol. 84. No. 7. pp. 695-710.
GOST all authors (up to 50)
Copy
Gershovich P. M., Karabelskii A. V., Ulitin A. B., Ivanov R. A. The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells // Biochemistry (Moscow). 2019. Vol. 84. No. 7. pp. 695-710.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S0006297919070022
UR - https://doi.org/10.1134%2FS0006297919070022
TI - The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells
T2 - Biochemistry (Moscow)
AU - Gershovich, P. M.
AU - Karabelskii, A V
AU - Ulitin, A B
AU - Ivanov, R. A.
PY - 2019
DA - 2019/07/13 00:00:00
PB - Pleiades Publishing
SP - 695-710
IS - 7
VL - 84
SN - 0006-2979
SN - 1608-3040
ER -
Cite this
BibTex
Copy
@article{2019_Gershovich,
author = {P. M. Gershovich and A V Karabelskii and A B Ulitin and R. A. Ivanov},
title = {The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells},
journal = {Biochemistry (Moscow)},
year = {2019},
volume = {84},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134%2FS0006297919070022},
number = {7},
pages = {695--710},
doi = {10.1134/S0006297919070022}
}
Cite this
MLA
Copy
Gershovich, P. M., et al. “The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells.” Biochemistry (Moscow), vol. 84, no. 7, Jul. 2019, pp. 695-710. https://doi.org/10.1134%2FS0006297919070022.
Labs
Profiles