Journal of Analytical Chemistry, volume 76, issue 12, pages 1438-1448
Enantioselective Voltammetric Sensors Based on Amino Acid Complexes of Cu(II), Co(III), and Zn(II)
R A Zilberg
1
,
L R Zagitova
1
,
I V Vakulin
1
,
Yu A Yarkaeva
1
,
Yu B Teres
1
,
T V Berestova
1
Publication type: Journal Article
Publication date: 2021-12-14
Journal:
Journal of Analytical Chemistry
scimago Q3
wos Q4
SJR: 0.242
CiteScore: 2.1
Impact factor: 1
ISSN: 10619348, 16083199
Analytical Chemistry
Abstract
The electrochemical and analytical characteristics of enantioselective sensors based on glassy carbon electrodes modified by chelate complexes (bis(L-phenylalaninate) copper(II), glycinato-L-phenylalaninate copper(II), tris(L-phenylalaninate) cobalt(II), bis(L-phenylalaninate) zinc) are studied. It is found that the most promising sensor for determining tryptophan enantiomers is the sensor modified by copper(II) (bis)L-phenylalaninate. In determining tryptophan enantiomers, this sensor provides a linear concentration range from 6.25 × 10–7 to 0.5 × 10–3 M for L-tryptophan and from 5 × 10–6 to 0.5 × 10–3 M for D-tryptophan. The sensor is more sensitive to L-tryptophan. The proposed sensor was used for the recognition and determination of tryptophan enantiomers in human urine and plasma samples, and also in a mixture of enantiomers. The statistical assessment of the results of determinations by the spiked–found method indicates the absence of a significant systematic error.
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