Perfilova, Yulia Anatolyevna
PhD in Chemistry
Publications
22
Citations
236
h-index
10
Research interests
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Gubaidullin R.R., Perfilova Y.A., Parfenova L.V.
Abstract:
Camphor and carvone exhibit a broad spectrum of biological activity, which determines the prospect
of their use as a platform for functionalization to obtain the analogues as potential drugs. The functionalization
of camphor and carvone often involves changes to the skeleton of the molecules or their fragmentation. Therefore,
in modern medicinal chemistry, research aimed at the development of effective approaches to the synthesis
of semi-synthetic derivatives of camphor and carvone with preservation of the native framework, demonstrating
high biological activity, is in demand. The present work is aimed at the synthesis of new propynyl analogues
of camphor and carvone, as well as their conjugates with mono- and disaccharides via Cu-catalyzed
cycloaddition of acetylenes and azides (CuAAC). Alkylation of camphor and carvone with propargyl bromide
in the presence of the base KN(SiMe3)2–Et3B in 1,2-dimethoxyethane (DME) at room temperature provides the
target products with yields of 69% and 47%, respectively. Glycosyl azides were obtained by the reaction of
peracetylated sugars with trimethylsilyl azide in the presence of SnCl4.The synthesis of 1,2,3-triazolyl glycoconjugates
of camphor and carvone with mono- and disaccharides was carried out through Cu(I)-catalyzed
1,3-dipolar cycloaddition of azides to acetylenes (CuAAC) in the presence of Cu and CuSO4·5H2O. The structures
of the synthesized compounds were determined by NMR. The new propynyl-substituted camphor and
carvone, as well as their 1,2,3-triazolylglycoconjugates, can be used as promising building blocks for medicine
chemistry.
Yarkaeva Y.A., Dymova D.A., Nazyrov M.I., Zagitova L.R., Maistrenko V.N.
For the selective detection of the antibiotic lincomycin, we developed a voltammetric sensor based on a glassy carbon electrode modified with reduced graphene oxide and polyarylenephthalide containing diphenylenethio and diphenyleneoxide fragments in the main chain of the polymer in the 1:1 ratio with lincomycin molecular imprints obtained by phase inversion. Using FTIR spectroscopy, electrochemical impedance spectroscopy, cyclic and differential-pulse voltammetry, the electrochemical and analytical characteristics of the sensor were studied. The detection of lincomycin was carried out by differential pulse voltammetry. The linear concentration range was 2.5·10–7–5·10–4 M with a limit of detection of 6.8·10–8 M. It was shown that the presence of molecular imprints increases the sensitivity of the developed sensor in comparisons with a sensor with non-imprinted polymer by a factor of 3.05.
Yarkaeva Y., Nazyrov M., Abdullin Y., Kovyazin P., Maistrenko V.
AbstractFor medicine and pharmaceuticals, the problem of determining and recognizing the enantiomers of biologically active compounds is an actual issue because the enantiomers of the same substance can have different effects on living organisms. This paper describes the development of an enantioselective voltammetric sensor (EVS) based on a glassy carbon electrode (GCE) modified with mesoporous graphitized carbon black Carbopack X (CpX) and a fulvene derivative (1S,4R)‐2‐cyclopenta‐2,4‐dien‐1‐ylidene‐1‐isopropyl‐4‐methylcyclohexane (CpIPMC) for recognition and determination of tryptophan (Trp) enantiomers. Synthesized CpIPMC was characterized by 1H and 13C nuclear magnetic resonance (NMR), chromatography–mass spectrometry, and polarimetry. The proposed sensor platform was studied by Fourier‐transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). Using the square‐wave voltammetry (SWV), it was established that the developed sensor is an effective chiral platform for the quantitative determination of Trp enantiomers, including in a mixture and in biological fluids like urine and blood plasma, with adequate precision and recovery ranged from 96% to 101%.
Yarkaeva Y., Maistrenko V., Dymova D., Zagitova L., Nazyrov M.
• To AMX determination, sensors based on molecular imprinted PANI and PMOA were developed. • PANI and PMOA were obtained through electrochemical polymerization. • The interaction energy of AMX-PMOA complex is greater than AMX-PANI complex. • PMOA based MIP-sensor has a higher sensitivity, selectivity, and lower detection limit. • Proposed MIP-sensors determine AMX in urine and blood plasma with high accuracy. In this work, sensors based on molecular imprinted polyaniline (MIPANI) and poly-2-methoxyaniline (MIPMOA) for amoxicillin (AMX) determination were developed and compared with each other. MIPANI and MIPMOA were deposited on the surface of modified by graphene oxide (GO) glassy carbon electrode (GCE) through electrochemical polymerization using cyclic voltammetry, which was carried out in a 1 M sulfuric acid solution containing the corresponding monomer and amoxicillin as a template, followed by removal of the template. Using a scanning electron microscopy and electrochemical impedance spectroscopy, the morphology and electrochemical properties of the modified surface of GCE were studied. The applying PANI and PMOA on the GCE/GO surface leads to a decrease in [Fe(CN) 6 ] 3-/4− currents. The electron transfer resistance on PMOA sensor (62 ± 4 Ω) is lower than on PANI sensor (71 ± 5 Ω). The areas of the electroactive surface of GCE/GO/PANI and GCE/GO/PMOA are 6.64 ± 0.12 mm 2 and 7.75 ± 0.14 mm 2 , respectively. After the removal of the AMX, the electron transfer rate increases due to the formation of pores in the polymers through which [Fe(CN) 6 ] 3-/4− ions penetrate. Using FTIR spectroscopy, it was shown that amoxicillin is incorporated into both polymer films. In this case, the binding of AMX to PMOA is stronger, which is confirmed by quantum chemical modeling. The optimal conditions for analysis were selected: the number of polymerization cycles was 7, the template concentration was 1 mM, and the pH of the analyzed solution was 7.00. Square wave voltammograms MIPANI and MIPMOA sensors show a pronounced electrooxidation peak, which are linear over the AMX concentration range of 1.0 × 10 −5 – 5.0 × 10 −3 and 5.0 × 10 −6 – 5.0 × 10 −3 M with detection limits of 2.6 × 10 −6 and 6.1 × 10 −7 M, respectively. It is shown that the MIPMOA sensor exhibits higher sensitivity and selectivity to AMX than MIPANI sensor, as well as high accuracy in determining AMX in urine and blood plasma.
Zagitova L., Yarkaeva Y., Zagitov V., Nazyrov M., Gainanova S., Maistrenko V.
• A novel voltammetric chiral sensor (GCE/rGO-TsPro-Cs) for Nap enantiomers was designed. • Combining rGO and TsPro functionalized Cs for enhancing selectivity of Nap recognition. • The stronger affinity for R-Nap leads to a higher electrochemical signal than S-Nap. • The sensor can achieve quantitative analysis of Nap enantiomers with LOD of 0.4 μM. • The proposed sensor could be utilized to analyze the amount of R-Nap in mixture. The chemical analysis of chiral compounds is of concern to researchers in the field of science and technology due to the various physiological and therapeutic properties of enantiomers. This experimental work provides novel sensor based on glassy carbon electrode (GCE) modified by N -tosylproline functionalized chitosan (TsPro-Cs) and reduced graphene oxide (rGO) for voltammetric recognition of naproxen (Nap) enantiomers. Each component of the modifying coating contributes to the improvement of the analytical and operational characteristics of sensor. The proposed sensor was characterized by fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Electrochemical recognition and quantification of Nap enantiomers were carried out using differential-pulse voltammetry (DPV). The oxidation peaks current ratio ( I R / I S ) of DPV measurements could be reached at 1.4 and peaks potential separation ( E R – E S ) of 40 mV. It was supposed that the chiral recognition occurred due to steric effect between N -tosylproline functionalized chitosan and Nap enantiomers. The binding energy of the chiral selector with the analyte molecule is higher for R-Nap than for S-Nap by 9.5 kcal/moll according to computational studies. The linear determination range was established as 20–500 μM for both enantiomers and detection limits of 0.4 μM and 0.9 μM were obtained for R- and S-Nap, respectively. The electrode showed good reproducibility with relative standard deviations of 1.8 % and 2.1 % for R- and S-Nap, respectively. The proposed sensor GCE/rGO-TsPro-Cs correctly determined Nap enantiomers in biological fluids with adequate precision and recovery ranged from 94 to 99 %. The developed sensor can determine the ratio of Nap isomers in enantiomeric mixture, which suggests that this sensor is an attractive candidate for practical use. This novel GCE/rGO-TsPro-Cs sensor can be a promising tool as an express device for monitoring the therapy of various diseases, as well as at the stage of drug production, and also for monitoring the impact of naproxen enantiomers on ecosystems and human health.
Zil’berg R.A., Zagitova L.R., Vakulin I.V., Yarkaeva Y.A., Teres Y.B., Berestova T.V.
The electrochemical and analytical characteristics of enantioselective sensors based on glassy carbon electrodes modified by chelate complexes (bis(L-phenylalaninate) copper(II), glycinato-L-phenylalaninate copper(II), tris(L-phenylalaninate) cobalt(II), bis(L-phenylalaninate) zinc) are studied. It is found that the most promising sensor for determining tryptophan enantiomers is the sensor modified by copper(II) (bis)L-phenylalaninate. In determining tryptophan enantiomers, this sensor provides a linear concentration range from 6.25 × 10–7 to 0.5 × 10–3 M for L-tryptophan and from 5 × 10–6 to 0.5 × 10–3 M for D-tryptophan. The sensor is more sensitive to L-tryptophan. The proposed sensor was used for the recognition and determination of tryptophan enantiomers in human urine and plasma samples, and also in a mixture of enantiomers. The statistical assessment of the results of determinations by the spiked–found method indicates the absence of a significant systematic error.
Yarkaeva Y.A., Maistrenko V.N., Zagitova L.R., Nazyrov M.I., Berestova T.V.
• A chiral sensors based on GCE modified by composites with amino acid complexes of Cu(II) and Zn(II) was developed. • R- and S-Atn interact with the Cu(II) and Zn(II) amino acid complexes by the ligands exchange. • Differences in the maximum currents and the potentials of R-, S-Atn oxidation peaks were observed. • For reliable recognition of R- and S-Atn, the proposed sensors were combined to sensor system by chemometric methods. • The sensor system correctly recognize R- and S-Atn in enantiomeric mixture. For recognition and determination of atenolol (Atn) enantiomers the enantioselective voltammetric sensor system based on glassy carbon electrodes modified by composites of polyarylenephthalide and chiral amino acid complexes of Cu(II) and Zn(II) – glycine- l -alaninate and glycine- l -argininate Cu(II), bis - l -phenylalaninate Zn(II) is developed. The enantioselectivity of the sensors is explained by the presence of chiral amino acids in the complexes which can be exchanged with Atn enantiomers and form mixed-ligand complexes of different stability. The electrochemical and analytical characteristics of the sensors were studied. It was shown that the sensors are cross-sensitive to Atn enantiomers. A sensor system based on them with chemometric processing of analytical signals using the methods of principal components and projection to latent structures was used to recognize and determine S- and R-Atn in mixtures with different ratios of enantiomers. The content of S-Atn was established with a relative standard deviation of less than 9% and recoveries ranging from 95% to 102%. The use of a sensor system makes it possible to eliminate errors of the first kind and to minimize errors of the second kind, to increase the percentage of correctly recognized samples up to 99%.
Yarkaeva Y.A., Islamuratova E.N., Zagitova L.R., Gus’kov V.Y., Zil’berg R.A., Maistrenko V.N.
We developed an enantioselective voltammetric sensor based on a carbon-paste electrode modified by enantiomorphic crystals of bromotriphenylmethane for the recognition and determination of tryptophan enantiomers. Enantiomorphic crystals of bromotriphenylmethane were obtained under the condition of Viedma ripening. The electrochemical and analytical characteristics of the sensor were studied. The proposed sensor was used to recognize and determine the enantiomers of L- and D-tryptophan in model solutions of pharmaceutical preparations and in human urine and blood plasma samples. The sensor is easy to manufacture and exhibits high reproducibility and stability. It was shown that, in using chemometric data processing, the presence of even slight differences between the voltammograms of enantiomers recorded using the proposed carbon-paste electrode is sufficient for their reliable recognition.
Zilberg R.A., Teres Y.B., Zagitova L.R., Yarkaeva Y.A., Berestova T.V.
A voltammetric sensor based on a composite of polyarylene phthalide and graphitized carbon black Carboblack C modified with chelate complexes of L-argenato-L-alaninate of copper (II) has been developed for the recognition and selective determination of tryptophan enantiomers. The conditions for modifying the sensor are optimized, the effective surface area (A = 4.38 ± 0.06 mm2) and the effective resistance (Ret = 1.29 ± 0.08 kΩ) are calculated. The optimal conditions for recording voltammograms of tryptophan enantiomers are selected: the range of operating potentials is 0.5-1.2 V, the potential sweep rate is 20 mV/s, the holding time of the electrode in the test solution is 5 s. The electrochemical and analytical characteristics of the sensor were studied when registering differential pulse voltammograms of tryptophan enantiomers. It is shown that the dependence of the analytical signal on the concentration is linear in the range from 1.25·10-6 to 1·10-3 M with detection limits of 0.90·10-6 M for L-Trp and 0.66·10-6 M for D-Trp. The developed sensor shows the greatest sensitivity to D-Trp. The sensor has been successfully tested to determine the content of L- and D-Trp in enantiomer solutions in the presence of excipients that are part of medicines and biologically active additives. The proposed sensor allows the determination of tryptophan enantiomers in human urine and blood plasma. To evaluate the analytical capabilities of the sensor, the "entered-found" method was used. When determining tryptophan enantiomers in model solutions, the relative standard deviation does not exceed 2.3 %, and the relative error is 1.7 %. When determining D- and L-Trp in biological fluids, the relative standard deviation ranges from 0.3-1.7 %, and the relative error ranges from 0.3-5.6 %. The research results show that there is no significant systematic error.
Zagitova L.R., Maistrenko V.N., Yarkaeva Y.A., Zagitov V.V., Zilberg R.A., Kovyazin P.V., Parfenova L.V.
To achieve satisfactory recognition and determination of tryptophan (TRP) enantiomers a chiral voltammetric sensor based on carbon black paste electrode (CBPE) containing Carboblack C powder and 3-neomenthylindene (NMI) chiral selector is developed in this work. A possible recognition mechanism as well as chiral selectivity have been explained using the molecular dynamics simulation. It was shown that 3-neomenthylindene attracts to TRP enantiomers via Van der Waals and π-π-stacking interactions. Compared with D-TRP, the sensor indicates favorable chiral recognition towards L-TRP with a selectivity coefficient of 1.34. The higher response signal of L-TRP than D-TRP is due to the energetically more favorable interaction of 3-neomenthylindene with L-TRP, which is confirmed by a change in the total energy of the system. CBPE modified by NMI was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FT-IR). The electrochemical and analytical characteristics of the sensor and conditions of the voltammogram registration were studied by differential pulse voltammetry (DPV). It was found that the oxidation of TRP enantiomers on CBPE/NMI is the diffusion-controlled process. The experimental results indicate a linear correlation between the peak currents of TRP enantiomers and their concentration in the range from 2.5 μM to 0.3 mM, leading to a detection limit of 1.71 μM and 2.23 μM for L- and D-TRP, respectively. The practical capabilities of the proposed sensor were demonstrated by analyzing human urine and blood plasma with satisfactory recoveries ranging from 95.2% to 99.0%. L-TRP was recognized in dietary supplements using projection to latent structures discriminant analysis. The present sensor also can detect the enantiomeric composition based on current signals with the different total concentrations of the mixture. The selectivity, stability, and reproducibility of the proposed sensor were studied as well.
Yarkaeva Y.A., Dubrovskii D.I., Zil’berg R.A., Maistrenko V.N., Kornilov V.M.
An enantioselective voltammetric sensor based on a glassy carbon electrode modified with a composite of a polyelectrolyte complex of chitosan, Carboblack C graphitized thermal carbon black, and 3,4,9,10-perylenetetracarboxylic acid is developed for the recognition and determination of tyrosine enantiomers. The enantioselectivity of the sensor is due to the formation of self-organizing chiral nanoclusters of 3,4,9,10-perylenetetracarboxylic acid. The electrochemical and analytical characteristics of the sensor are studied. The proposed sensor is used to recognize and determine L- and D-enantiomers of tyrosine in samples of urine and human blood plasma, as well as in a mixture. To increase the probability of the recognition of tyrosine enantiomers in determining them in a mixture, the chemometric method of projection to latent structures is used. It is shown that the proposed sensor ensures the determination of the ratio of L- and D-enantiomers of tyrosine in a mixture with a high probability and a relative error of less than 8%.
Yarkaeva Y.A., Dubrovskii D.I., Zil’berg R.A., Maistrenko V.N.
Voltammetric sensors and a sensor system based on gold electrodes modified with polyarylenephthalides (chlorinated polyphthalidylidene fluorene and polyphthalidylidene diphenyl and brominated polyphthalidylidene diphenyl) for the identification of cysteine are developed. The surface morphology of the modified electrodes and electrochemical and analytical characteristics of the sensors are studied, the conditions for the electrochemical oxidation of cysteine and the production of an analytical signal are optimized. The proposed sensors and sensor system, with chemometric processing of response signals, allows recognizing manufacturers of cysteine-containing pharmaceutical preparations. The use of the voltammetric sensor system can significantly increase the percentage of correctly recognized samples in comparison with the registration of voltammograms on separate electrodes.
Zil’berg R.A., Maistrenko V.N., Yarkaeva Y.A., Dubrovskii D.I.
We developed an enantioselective voltammetric sensor system based on glassy carbon electrodes modified by polyarylenephthalide composites with α-, β-, and γ-cyclodextrins for the selective recognition and determination of tryptophan (Trp) enantiomers. The electrochemical characteristics of the electrodes and surface morphology were studied by cyclic voltammetry, electrochemical impedance spectroscopy, and atomic force microscopy. The proposed sensor system with recording voltammograms by three electrodes and the chemometric processing of the data using principal component analysis and projections to latent structures discriminant analysis was used to recognize tryptophan enantiomers in food additives and to determine their manufacturer.
Zilberg R.A., Yarkaeva Y.A., Dubrovsky D.I., Zagitova L.R., Maistrenko V.N.
Voltammetric sensors and sensory system based on glassy carbon electrodes modified by polyarylenephthalides (chlorinated polyphthalidylidenefluorene, polyphthalidylidene diphenyl and brominated polyphthalidylidene diphenyl) were developed for the recognition and determination of warfarin. The electrochemical and analytical characteristics of the sensors were studied. The optimal conditions for recording voltammograms of warfarin oxidation were established: the range of working potentials was 0.5 ÷ 1.2 V, scan rate was 20 mVs-1, the electrode holding time in the analyzed solution was 30s, and the pH of the supporting electrolyte was 6.86 (Na2HPO4 + KH2PO4). Using the values of the slope of the dependence log ip = log v + const (Δlg ip / Δlg v = 0.7 ÷ 0.9), it was found that the rate-controlling step of warfarin oxidation was the depolarizer adsorption on the surface of the polymer modifier. The linear range of the dependence of the maximum of warfarin oxidation peak on the concentration was 0.3×10-6 ÷ 0.5×10-3 М. Using the “added-found” method, the accuracy of determining the warfarin content in the model solutions was evaluated. The relative standard deviation and relative measurements error didn’t exceed 4.63% and 11.1% respectively. By the means of chemometrics methods (principal components analysis and SIMCA) the possibility of the recognition of warfarin preparations without isolating the active substances in dosage forms was shown, which made it possible to distinguish pharmaceutical preparations from the different manufacturers. At the same time, the sample preparation procedure was significantly simplified, and the cost and time of the analysis were reduced. It was also shown that the use of the multisensory system of the “electronic tongue” type significantly increased the percentage of correctly recognized samples in comparison to the registration of voltammograms on the single sensor. The proportion of correctly recognized samples was 97-100%. Keywords : warfarin, voltammetry, polyarylenephthalide, modified electrodes, sensor system (Russian) DOI: http://dx.doi.org/10.15826/analitika.2019.23.4.003 R.A. Zilberg, Yu.A. Yarkaeva, D.I. Dubrovsky, L.R. Zagitova, V.N. Maistrenko Bashkir State University, Department of Chemistry, 32, Validy Str., Ufa, 450076, Russian Federation
Zilberg R.A., Yarkaeva Y.A., Provorova Y.R., Gus’kov V.Y., Maistrenko V.N.
The possibilities of new voltammetric sensors based on glassy carbon electrodes modified by the composites of polyarylenephthalide with melamine, cyanuric acid, α- and β-cyclodextrins for the determination of propranolol enantiomers in the model solutions of pharmaceutical and biological fluids were studied. The electrochemical and analytical characteristics of voltammograms of propranolol enantiomers and their pharmaceutical dosage forms on the modified electrodes were obtained. The voltamperograms of the propranolol enantiomers on these electrodes differ among themselves both in the values of the instantaneous currents and in the potentials of oxidation. The proposed sensors allowed determining the propranolol enantiomers in a racemic mixture and in a mixture with the predominance of one of the enantiomers. The dependence of the analytical signal on the concentration of propranolol was linear in the range from 0.021 to 0.675 mM, the detection limit was (5.28÷8.37)×10 -6 М in the solutions of enantiomers and (2.75÷5.57)×10 -5 М in pharmaceutical dosage forms respectively. The relative standard deviation for the pure solutions of propranolol enantiomers ranged from 0.011 to 0.064, and for pharmaceutical dosage forms of propranolol it ranged from 0.022 to 0.109. The auxiliary substances did not have a significant interfering effect. The developed enantioselective sensors were used for the determination of propranolol enantiomers in the biological fluids. The statistical evaluation of the results by the "spiked -found" method indicated that there was no significant systematic error. The relative standard deviation in the determination of propranolol enantiomers ranged from 0.071 to 0.109 in the urine, and from 0.116 to 0.146 in the plasma. Keywords : enantiomers, propranolol, voltammetry, polyarylenephthalide, melamine, cyanuric acid, cyclodextrins, composite electrodes, auxiliary substances, biological fluids DOI: http://dx.doi.org/10.15826/analitika.2018.22.3.012 (Russian) R.A. Zilberg, Yu.A. Yarkaeva, Yu.R. Provorova, V.Yu. Gus’kov, V.N. Maistrenko Bashkir State University, Zaki Validi str. 32, Ufa, 450076, Russian Federation
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Zilberg R.A., Bulysheva E.O., Teres Y.B., Volkova A.A., Ishmakayeva G.I., Mukhametdinov G.R., Vakulin I.V.
A multisensory system of the "electronic tongue" type was developed based on glassy carbon electrodes modified with PEC@GO, PEC@SWCNT, PEC@CB and PEC@CP composites for the identification of pharmaceutical preparations of naproxen using differential pulse voltammetry. To improve the reliability of voltammetric recognition of pharmaceutical preparations of naproxen, chemometric data processing using PCA and SIMCA was proposed. It was shown that the multisensory system of the "electronic tongue" type correctly distinguishes 100% of the samples. To achieve such a degree of recognition, the multisensory system should include at least 4 sensors. The accuracy of recognition was tested on 3 samples of commercially available naproxen pharmaceuticals: "Nalgesin", "Teraliv", and "Nexemezin", produced by different manufacturers.
Pan Q., Guan Y., Xu W., Zhao J., Liu Y., Cui L., Zhou J.
Nemati S.S., Dehghan G., Soleymani J., Jouyban A.
Abramov I.A., Gainanova S.I., Zagitova L.R., Maistrenko V.N.
Antibacterial drugs have become an integral part of the food industry and agriculture in the modern world. The presence of even trace amounts of antibiotics in food of animal origin can lead to the development of allergic reactions and direct toxic effects in the human body. In this regard, it is required to create sensitive and selective methods for the determination of antibacterial drugs in order to prevent their excessive consumption. In this work, a glass-carbon voltammetric sensor based on layer-by-layer deposited electrospun graphene oxide and functionalized S-N,N’-bis(1-phenylethyl)malonamide fullerene is proposed for the determination of levofloxacin (Lev, S-(-)-ofloxacin) by differential pulse voltammetry. The calibration plot is linear over two ranges of 1.0 × 10-6 -6.0 × 10-5 M and 6.0 × 10-5 -5.0 × 10-4 M Lev with sensitivity factors of 107 and 58.0 μA/mM, respectively. The detection limit and lower limit of detectable contents were 1.8 × 10-7 M and 6.04 × 10-7 M, respectively. The selectivity of the sensor to Lev was evaluated with respect to some fluoroquinolone antibiotics: ciprofloxacin, lomefloxacin, enrofloxacin. The sensor was used for the determination of Lev in meat and milk by differential pulse voltammetry.
Yarkaeva Y.A., Nazyrov M.I., Dymova D.A., Maistrenko V.N.
For selective determination of the antibiotic clarithromycin, a voltammetric sensor based on a glass-carbon electrode modified with a composite of chitosan, Carboblack C graphitized carbon black and polyarylenephthalide containing diphenylene-thio- and diphenylene oxide fragments in the main chain of the polymer in the ratio of 1 : 2 with molecular imprints of clarithromycin obtained by phase inversion method was developed. The composition and morphology of the modifying coating were studied using IR spectroscopy and scanning electron microscopy. The electrochemical and analytical characteristics of the sensor were studied by electrochemical impedance spectroscopy, cyclic and differential-pulse voltammetry. Optimal conditions for analytical signal registration were selected. Using [Fe(CN) ]63−/4− as a probe, the linear range of determined concentrations was 1 × 10-7 -5 × 10-4 M with a detection limit of 5.3 × 10-8 M. It is shown that the use of a polymer with molecular imprints of clarithromycin increases the sensitivity of the sensor almost 10 times compared to the non-imprinted polymer. The proposed sensor was tested on samples of urine, blood plasma, as well as food products (meat, milk), the degree of extraction was 90-96, 80 and 92%, respectively, and the relative standard deviation did not exceed 10% in all cases.
Nazyrov M.I., Perfilova Y.A., Abdullin Y.R., Kovyazin P.V., Maistrenko V.N.
To recognize and determine the enantiomers of clopidogrel, a sensor system based on a glassy carbon electrode modified with Carbopack X mesoporous carbon black and cyclopentadiene derivatives – (1S)-2-cyclopenta-2,4-dien-1-yl-1,7,7-trimethylbicyclo[2.2.1]heptane; (1S, 2S, 4R)-2-cyclopenta-1,3-dien-1-yl-1-isopropyl-4-methylcyclohexane; 9-[(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl]-9H-fluorene. Due to the unique properties of Carbopack X, such as large surface area and high conductivity, it was possible to obtain a mechanically stable and sensitive sensor layer that firmly retains chiral selector molecules on its surface. The morphological, electrochemical and analytical properties of the obtained sensors were studied by scanning electron microscopy, electrochemical impedance spectroscopy, cyclic and differential pulse voltammetry. The determination of clopidogrel enantiomers in biological fluids has been carried out; linear dependences of oxidation peak currents on their concentration in solution for all sensors are preserved in the concentration range from 1 × 10–6 to 5 × 10–4 M. The sensors are cross-sensitized, which allowed combining them into a sensor system with high enantioselectivity and sensitivity towards clopidogrel enantiomers. With the proposed sensor system, the probability of correctly recognizing samples increases compared to single sensors. In all cases, the content of R-clopidogrel in the mixture is correctly determined with a relative error not exceeding 9% and a degree of discovery ranging from 96 to 102%.
Lebedeva E., Nizameeva G., Nizameev I., Kuznetsova V., Kadirov M.
In this paper, the results of the electrocatalytic behavior of a series of copper sodium pectate complexes with different Cu2+ contents (5, 10, 15, 20, 25%) towards the oxygen reduction reaction (ORR) are presented. To investigate the catalytic activity of the studied complexes in ORR, the cyclic voltammograms (CVA) recorded in an oxygen-saturated environment and inert argon gas were compared. Clear reduction peaks are observed in the CVA, confirming the electrochemical activity of the complexes in the oxygen reduction reaction. The kinetics and mechanism of the oxygen reduction reaction on the glassy carbon modified with the complexes in an acidic 0.5 M H2SO4 medium were analyzed. The results obtained by cyclic voltammetry at different scan rates show that the ORR on the copper sodium pectate complexes supported on the glassy carbon is diffusion-controlled. The calculation of the number of electrons participating in the electrochemical reaction was carried out. It was found that the best catalyst of the entire series of samples is a sodium pectate complex with a 5% copper content (n = 4). It was noted that the compound is characterized by a large specific surface area. An increase in the amount of copper ions in coordination biopolymers leads to film formation and a decrease in catalytic activity.
Shaidarova L.G., Chelnokova I.A., Il’ina M.A., Gafiatova I.A., Budnikov H.C.
Flexible electrodes based on laser-induced graphene as an analytical platform to monitor amoxicillin
de Souza C.C., Carvalho M.S., de Oliveira W.B., Lisboa T.P., Oliveira R.S., Lopes O.F., Muñoz R.A., Matos M.A., Matos R.C.
Singh A.K., Yadav R., Singh A., Rosy
Gubaidullin R., Parfenova L.
Georgescu-State R., Stefan-van Staden R., van Staden J.K., State R.N.
Sarangi S., Srivastava R., Gogoi-Tiwari J., Kar R.K.
Hong T., Zhou Q., Liu Y., Ji Y., Tan S., Zhou W., Cai Z.
Innovative chiral capillary silica monoliths (CSMs) were developed based on DNA nanoflowers (DNFs). Baseline separation of enantiomers such as atenolol, tyrosine, histidine, and nefopam was achieved by using DNF-modified CSMs, and the obtained resolution value was higher than 1.78. To further explore the effect of DNFs on enantioseparation, different types of chiral columns including DNA strand containing the complementary sequence of the template (DCT)-modified CSMs, DNF2-modified CSMs, and DNF3-modified CSMs were prepared as well. It was observed that DNF-modified CSMs displayed better chiral separation ability compared with DCT-based columns. The intra-day and inter-day repeatability of model analytes’ retention time and resolution kept desirable relative standard deviation values of less than 8.28%. DNF2/DNF3-modified CSMs were able to achieve baseline separation of atenolol, propranolol, 2′-deoxyadenosine, and nefopam enantiomers. Molecular docking simulations were performed to investigate enantioselectivity mechanisms of DNA sequences for enantiomers. To indicate the successful construction of DNFs and DNF-modified CSMs, various charaterization approaches including scanning electron microscopy, agarose gel electrophoresis, dynamic light scattering analysis, electroosmotic flow, and Fourier-transform infrared spectroscopy were utilized. Moreover, the enantioseparation performance of DNF-modified CSMs was characterized in terms of sample volume, applied voltage, and buffer concentration. This work paves the way to applying DNF-based capillary electrochromatography microsystems for chiral separation.
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Wen Z., Ding L., Zhang M., You F., Yuan R., Wei J., Qian J., Wang K.
Over use of lincomycin (LIN) as antibiotic in animals can lead to multiple harmful impacts to public health, thus detection of LIN at trace level in milk and chicken sample matrixes is vital. In this work, Zinc phthalocyanine nanoparticles sensitized MoS2 (ZnPc/MoS2) was firstly developed as a novel photocathode material combined with nitrogen-doped graphene-loaded TiO2 nanoparticles (TiO2/NG) as photoanode material to construct a dual-photoelectrode photofuel cell (PFC). The as-prepared membrane/mediator-free PFC achieved excellent output performance that the maximum power density (Pmax) reached 11.83 μW cm-2. Specific aptamers are adopted as LIN recognition elements, the as-proposed self-powered aptasensor for LIN exhibited a linear scope in 10-11 -10-5 mol L-1 along with a low detection limit (3S/N) of 3.33 pmol L-1. Consequently, such high-power density dual-photoelectrode PFC aptasensor may be a reassuring candidate electrochemical sensor for the detection of trace contamination in food samples.
Fan Y., Liu Z., Wang J., Cui C., Hu L.
A novel electrochemiluminescence (ECL) aptasensor for the determination of lincomycin (LIN) was developed based on CdS QDs/carboxylated g-C3N4 (CdS QDs/C-g-C3N4). CdS QDs/C-g-C3N4 served as the substrate of the aptasensor, and then CdS QDs/C-g-C3N4-modified electrode was incubated with aptamer DNA (Apt-DNA). When the non-specific sites of the electrode surface was blocked by 6-mercaptohexanol, the ferrocene-labeled probe (Fer-DNA) was assembled onto the electrode surface through base complementation with Apt-DNA. In the absence of LIN, the ECL signal was quenched effectively by Fer-DNA and a decreased ECL emission (off state) was acquired. On the contrary, LIN was specifically bond with Apt-DNA, and Fer-DNA was detached from the aptasensor surface because of the deformation of Apt-DNA, resulting in an effectively enhanced ECL signal (on state). The constructed ECL aptasensor exhibited a wide detection range for LIN determination (0.05 ng mL−1–100 μg mL−1) with a low detection limit (0.02 ng mL−1). Importantly, the proposed ECL aptasensor showed outstanding accuracy and specificity for LIN determination, and also provided a potential strategy for other antibiotic determinations.
Wei M., Du X., Zhang Y., Shan X., Wang W., Chen Y., Jiang D., Xu F., Shiigi H., Chen Z.
A high-performance self-driven photoelectrochemical (PEC) platform was designed based on 0D N-doped Ti 3 C 2 quantum dots/oxygen vacancies (OVs) engineered 2D BiOBr nanosheets (N-doped Ti 3 C 2 QDs/BiOBr) nanocomposites for sensitive detection of lincomycin (Lin). The synergistic interplay between 0D N-doped Ti 3 C 2 QDs and 2D BiOBr can generate the fascinating interface of chemical/electronic coupling to further boost the PEC activity, including efficient charge transfer, extended the light absorption and increased carrier density. Experimental results demonstrated that the PEC response of the prepared OV-riched N-doped Ti 3 C 2 QDs/BiOBr van der Waals (vdW) heterostructures were 9-folds stronger than that of OV-deficient BiOBr. On the basis of the such excellent PEC performance, an ultrasensitive self-driven PEC aptasensor was developed with the assistance of Lin aptamer. The proposed sensor exhibited a wide linear response (1.0 × 10 −14 mol/L ∼ 1.0 × 10 −8 mol/L), a low detection limit (3.57 × 10 −15 mol/L, S/N = 3), excellent selectivity and good reproducibility, which provided a promising tool to detect Lin in real samples. This work not only offered a versatile protocol for a wide variety of PEC detection, but also paved the way for the development of more efficient PEC biosensor. • N–Ti 3 C 2 QDs/OV engineered BiOBr heterostructures were prepared by hydrothermal route. • OV concentration can be modulated by tuning N–Ti 3 C 2 QDs amount. • The photocurrent of OV-riched N–Ti 3 C 2 QDs/BiOBr was 9-folds higher than that of pure BiOBr. • A novel kind of self-driven PEC aptasensor was established for Lin assay. • The proposed sensor showed a wide linear range, a low detection limit, and etc.
Yarkaeva Y., Maistrenko V., Dymova D., Zagitova L., Nazyrov M.
• To AMX determination, sensors based on molecular imprinted PANI and PMOA were developed. • PANI and PMOA were obtained through electrochemical polymerization. • The interaction energy of AMX-PMOA complex is greater than AMX-PANI complex. • PMOA based MIP-sensor has a higher sensitivity, selectivity, and lower detection limit. • Proposed MIP-sensors determine AMX in urine and blood plasma with high accuracy. In this work, sensors based on molecular imprinted polyaniline (MIPANI) and poly-2-methoxyaniline (MIPMOA) for amoxicillin (AMX) determination were developed and compared with each other. MIPANI and MIPMOA were deposited on the surface of modified by graphene oxide (GO) glassy carbon electrode (GCE) through electrochemical polymerization using cyclic voltammetry, which was carried out in a 1 M sulfuric acid solution containing the corresponding monomer and amoxicillin as a template, followed by removal of the template. Using a scanning electron microscopy and electrochemical impedance spectroscopy, the morphology and electrochemical properties of the modified surface of GCE were studied. The applying PANI and PMOA on the GCE/GO surface leads to a decrease in [Fe(CN) 6 ] 3-/4− currents. The electron transfer resistance on PMOA sensor (62 ± 4 Ω) is lower than on PANI sensor (71 ± 5 Ω). The areas of the electroactive surface of GCE/GO/PANI and GCE/GO/PMOA are 6.64 ± 0.12 mm 2 and 7.75 ± 0.14 mm 2 , respectively. After the removal of the AMX, the electron transfer rate increases due to the formation of pores in the polymers through which [Fe(CN) 6 ] 3-/4− ions penetrate. Using FTIR spectroscopy, it was shown that amoxicillin is incorporated into both polymer films. In this case, the binding of AMX to PMOA is stronger, which is confirmed by quantum chemical modeling. The optimal conditions for analysis were selected: the number of polymerization cycles was 7, the template concentration was 1 mM, and the pH of the analyzed solution was 7.00. Square wave voltammograms MIPANI and MIPMOA sensors show a pronounced electrooxidation peak, which are linear over the AMX concentration range of 1.0 × 10 −5 – 5.0 × 10 −3 and 5.0 × 10 −6 – 5.0 × 10 −3 M with detection limits of 2.6 × 10 −6 and 6.1 × 10 −7 M, respectively. It is shown that the MIPMOA sensor exhibits higher sensitivity and selectivity to AMX than MIPANI sensor, as well as high accuracy in determining AMX in urine and blood plasma.
Zou J., Zhao G., Zhao G., Yu J.
• The basic principle of rational design of electrochemical chiral sensor for sensing is summarized. • Preparation of doped electrodes and their recognition performance for chiral enantiomers are summarized. • Construction of modified electrodes and their recognition performances are discussed. • The challenges and scientific prospects of new generation of modifiers in electrochemical chiral sensing are proposed. Chiral recognition, especially rendering specificity in biomolecular recognition, is a basic property of many biomolecules. Being closely related to the chirality of biomolecules, it has been regarded as one of the most important areas in biological and medical sciences due to the different effects in biological systems. Based on the possible interactions between chiral selectors and the enantiomers, various methods including chromatographic techniques such as gas or liquid chromatography, electromigration techniques such as capillary electrophoresis and so on were developed for the chiral separation and recognition of different optical isomers. Recently, chemical sensors and biosensors have been gradually designed and developed for the analysis of chiral compounds. Based on the difference in electrical response to different isomers, chiral identifications can be successfully implemented. Major successes in enantiomer recognition based on electrochemical analysis are reviewed. The research data available for highly enantio -selective recognition are categorized into several subgroups according to specific topics and critically discussed for the period since 1994, and the latest techniques for electrochemical chiral recognition of enantiomers were also reviewed. Simultaneously, a brief conclusive summary and future perspectives are presented, and the challenges and scientific prospects of the newest generation of electrode modifiers in electrochemical sensing are also proposed.
Zagitova L., Yarkaeva Y., Zagitov V., Nazyrov M., Gainanova S., Maistrenko V.
• A novel voltammetric chiral sensor (GCE/rGO-TsPro-Cs) for Nap enantiomers was designed. • Combining rGO and TsPro functionalized Cs for enhancing selectivity of Nap recognition. • The stronger affinity for R-Nap leads to a higher electrochemical signal than S-Nap. • The sensor can achieve quantitative analysis of Nap enantiomers with LOD of 0.4 μM. • The proposed sensor could be utilized to analyze the amount of R-Nap in mixture. The chemical analysis of chiral compounds is of concern to researchers in the field of science and technology due to the various physiological and therapeutic properties of enantiomers. This experimental work provides novel sensor based on glassy carbon electrode (GCE) modified by N -tosylproline functionalized chitosan (TsPro-Cs) and reduced graphene oxide (rGO) for voltammetric recognition of naproxen (Nap) enantiomers. Each component of the modifying coating contributes to the improvement of the analytical and operational characteristics of sensor. The proposed sensor was characterized by fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Electrochemical recognition and quantification of Nap enantiomers were carried out using differential-pulse voltammetry (DPV). The oxidation peaks current ratio ( I R / I S ) of DPV measurements could be reached at 1.4 and peaks potential separation ( E R – E S ) of 40 mV. It was supposed that the chiral recognition occurred due to steric effect between N -tosylproline functionalized chitosan and Nap enantiomers. The binding energy of the chiral selector with the analyte molecule is higher for R-Nap than for S-Nap by 9.5 kcal/moll according to computational studies. The linear determination range was established as 20–500 μM for both enantiomers and detection limits of 0.4 μM and 0.9 μM were obtained for R- and S-Nap, respectively. The electrode showed good reproducibility with relative standard deviations of 1.8 % and 2.1 % for R- and S-Nap, respectively. The proposed sensor GCE/rGO-TsPro-Cs correctly determined Nap enantiomers in biological fluids with adequate precision and recovery ranged from 94 to 99 %. The developed sensor can determine the ratio of Nap isomers in enantiomeric mixture, which suggests that this sensor is an attractive candidate for practical use. This novel GCE/rGO-TsPro-Cs sensor can be a promising tool as an express device for monitoring the therapy of various diseases, as well as at the stage of drug production, and also for monitoring the impact of naproxen enantiomers on ecosystems and human health.
Salikhov R.B., Zilberg R.A., Mullagaliev I.N., Salikhov T.R., Teres Y.B.
Investigations of nanocomposite thin films based on polyarylene- phthalide, single-walled carbon nanotubes and graphene oxide have been carried out. Using these films as a transport layer, field-effect transistors were assembled and their output and transfer characteristics were measured. The mobility of charge carriers was estimated and the obtained values are as follows: μ PAP/GO = 0.020 cm 2 V −1 s −1 and μ PAP/SWCNT = 0.071 cm 2 V −1 s −1 .
Hu Y., Zhu Q., Wang Y., Liao C., Jiang G.
Antibiotics play a role in preventing and treating infectious diseases and also contribute to other health risks for humans. With the overuse of antibiotics, they are widely distributed in the environment. Long-term exposure to multiple antibiotics may occur in humans through medication and dietary intake. Therefore, it is critical to estimate daily intake and health risk of antibiotics based on urinary biomonitoring. This review compares the strengths and weaknesses of current analytical methods to determine antibiotics in urine samples, discusses the urinary concentration profiles and hazard quotients of individual antibiotics, and overviews correlations of antibiotic exposure with the risk of diseases. Liquid chromatography-tandem mass spectrometry is most applied to simultaneously determine multiple types of antibiotics at trace levels. Solid-phase extraction with a hydrophilic-lipophilic balance adsorbent is commonly used to extract antibiotics in urine samples. Fifteen major antibiotics with relatively higher detection frequencies and concentrations include sulfaclozine, trimethoprim, erythromycin, azithromycin, penicillin V, amoxicillin, oxytetracycline, chlortetracycline, tetracycline, doxycycline, ofloxacin, enrofloxacin, ciprofloxacin, norfloxacin, and florfenicol. Humans can be easily at microbiological effect-based risk induced by florfenicol, ciprofloxacin, azithromycin, and amoxicillin. Positive associations were observed between specific antibiotic exposure and obesity, allergic diseases, and mental disorders. Overall, the accessible, automated, and environmentally friendly methods are prospected for simultaneous determinations of antibiotics at trace level in urine. To estimate human exposure to antibiotics more accurately, knowledge gaps need to be filled up, including the transformation between parent and metabolic antibiotics, urinary excretion proportions of antibiotics at low-dose exposure and pharmacokinetic data of antibiotics in humans, and the repeated sampling over a long period in future research is needed. Longitudinal studies about antibiotic exposure and the risk of diseases in different developmental windows as well as in-depth research on the pathogenic mechanism of long-term, low-dose, and joint antibiotic exposure are warranted.
Shi Q., Tao C., Kong D.
Neomycin and lincomycin are widely used in the treatment of infections illnesses. However, the irrational and inappropriate of antibiotics contributes to threaten human health seriously. We developed a rapid and multiple detection strategy for trace amounts of neomycin (NEO) and lincomycin (LIN) in milk using Surface-Enhanced Raman Spectroscopy (SERS)-based lateral flow assay (LFA). The method used two SERS immunoprobes (a probe for NEO and a probe for LIN) were mixed and applied to the conjugate pad, and then, the NEO-OVA and LIN-OVA were mixed and coated on LFA as the only test line. Simultaneous quantitative detection of NEO and LIN was achieved by detecting the Raman intensity of captured immunoprobes on test line using a Raman spectrometer. Under optimized condition, NEO and LIN could be detected as low as 0.33 pg/mL and 0.29 pg/mL in 15 min with a sample volume of 100 μL. The practicality of the LFA in milk sample was also validated. The method is highly sensitive, accurate, and effective. It has a good chance to be employed for multiple antibiotics detection in food products.
Ji J., Qu L., Wang Z., Li G., Feng W., Yang G.
This study describes a facile strategy to synthesize the electrochemical chiral recognition tryptophan sensor based on carboxymethyl cellulose (CMC) and copper ions-complexed hydroxypropyl-β-cyclodextrin (HP-β-CD) in the presence of MWCNTs (GCE/MWCNTs/CMC-CD-Cu). Compared with D-Trp, the higher electrochemical signal of L-Trp was ascribed to the stronger affinity for L-type tryptophan, and the oxidation peak current ratio (I L /I D ) of DPV could be reached at 2.2 under the optimal experimental conditions. • A facile electrochemical chiral sensor (GCE/MWCNTs/CMC-CD-Cu) for Trp isomer was designed. • The oxidation peak current ratio (I L /I D ) of DPV could be reached at 2.2 under the optimal experimental conditions. • The stronger affinity for L-Trp leads to a higher electrochemical signal than D-Trp. • The sensor can achieve quantitative analysis of tryptophan enantiomers and has lower detection limit for L-Trp (0.81 μM) and D-Trp (1.9 μM). • The electrochemical chiral sensor could be utilized to analyze the amount of D-Trp in the enantiomer mixture solutions. The development of facile and convenient sensors for the chiral recognition of enantiomers is of great significance for medical and life science. Herein, a sensitive electrochemical sensor for the chiral recognition of tryptophan (Trp) enantiomers was developed based on the assembly of cellulose grafted with hydroxypropyl-β-cyclodextrins (CMC-CD), multi-walled carbon nanotubes (MWCNTs) and copper ions on the surface of a GCE. The morphologies and electrochemical behaviors of the prepared electrode (GCE/MWCNTs/CMC-CD-Cu) were characterized by differential pulse voltammetry (DPV), FT-IR, XPS, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The oxidation peak current ratio (I L /I D ) of DPV could be reached at 2.2 under the optimal experimental conditions. Compared with D-Trp, the higher electrochemical signal of L-Trp was ascribed to the stronger affinity for L-type tryptophan. Additionally, the as-prepared chiral sensor was successfully utilized to analyze the amount of D-Trp in the racemic mixture.
Gavrilă A., Stoica E., Iordache T., Sârbu A.
Molecular imprinting (MI) is the most available and known method to produce artificial recognition sites, similar to antibodies, inside or at the surface of a polymeric material. For this reason, scholars all over the world have found MI appealing, thus developing, in this past period, various types of molecularly imprinted polymers (MIPs) that can be applied to a wide range of applications, including catalysis, separation sciences and monitoring/diagnostic devices for chemicals, biochemicals and pharmaceuticals. For instance, the advantages brought by the use of MIPs in the sensing and analytics field refer to higher selectivity, sensitivity and low detection limits, but also to higher chemical and thermal stability as well as reusability. In light of recent literature findings, this review presents both modern and dedicated methods applied to produce MIP layers that can be integrated with existent detection systems. In this respect, the following MI methods to produce sensing layers are presented and discussed: surface polymerization, electropolymerization, sol–gel derived techniques, phase inversionand deposition of electroactive pastes/inks that include MIP particles.
Adawy A.
Many structures in nature look symmetric, but this is not completely accurate, because absolute symmetry is close to death. Chirality (handedness) is one form of living asymmetry. Chirality has been extensively investigated at different levels. Many rules were coined in attempts made for many decades to have control over the selection of handedness that seems to easily occur in nature. It is certain that if good control is realized on chirality, the roads will be ultimately open towards numerous developments in pharmaceutical, technological, and industrial applications. This tutorial review presents a report on chirality from single molecules to supramolecular assemblies. The realized functions are still in their infancy and have been scarcely converted into actual applications. This review provides an overview for starters in the chirality field of research on concepts, common methodologies, and outstanding accomplishments. It starts with an introductory section on the definitions and classifications of chirality at the different levels of molecular complexity, followed by highlighting the importance of chirality in biological systems and the different means of realizing chirality and its inversion in solid and solution-based systems at molecular and supramolecular levels. Chirality-relevant important findings and (bio-)technological applications are also reported accordingly.
Li J., Luo M., Jin C., Zhang P., Yang H., Cai R., Tan W.
Plasmonic bimetal nanostructures can be employed to amplify electrochemiluminescence (ECL) signals. In this work, a high-performance ECL platform was constructed using a europium metal-organic framework (MOF) as a luminophore and Au-Pt bimetallic nanorods (NRs) as a plasma source. Due to the SPR effect of Au-Pt NRs, the aptasensor exhibits 2.6-fold ECL intensity compared to that of pure polyaniline (PANI)-decorated perylene tetracarboxylic dianhydride (PTCA)/Eu MOF. Moreover, decoration with PTP greatly enhances the conductivity and stability of Eu MOF, resulting in sizeable plasmon-enhanced electrochemical luminescence. The as-designed plasmon-enhanced ECL aptasensor displayed highly sensitive detection for lincomycin (Lin). The as-proposed aptasensor could quantify Lin from 0.1 mg/mL to 0.1 ng/mL with a limit of detection (LOD) of 0.026 ng/mL.
Kaya S.I., Ozcelikay G., Armutcu C., Ozkan S.A.
We explain the development of an ultra-sensitive molecularly imprinted polymer-based electrochemical sensor for rapid and selective determination of bisphenol A (BPA) in human serum and water samples. Electropolymerization of functional monomer aniline was performed in the presence of BPA by cyclic voltammetry (CV) to prepare a molecularly imprinted poly(aniline) based GCE sensor (MIP(ANI)/GCE). The developed MIP surface was characterized using Fourier-transform infrared spectroscopy, Raman spectrometry, scanning electron microscopy, contact angle measurements, CV, and electrochemical impedance spectroscopy. The MIP(ANI)/GCE sensor showed a highly sensitive performance with a linear range of 1.0 and 8.0 × 10−15 M. The limit of detection (LOD) and limit of quantification (LOQ) values were 0.193 and 0.643 fM, respectively. The applicability of the MIP(ANI)/GCE was assessed by applying it to human serum and plastic bottled water samples. The LOD and LOQ values were calculated as 0.257 and 0.856 fM for the serum sample. Imprinting factor and interference studies were also carried out using similarly structured compounds and the most common interfering agents showing the selectivity of the MIP(ANI)/GCE sensor. Finally, the non-imprinted polymer (NIP)-based sensor was prepared to control the MIP(ANI)/GCE performance.
López Zavala M.Á., Anglés Vega D.
In this study, stainless-steel electrodes were used to effectively oxidize naproxen and its transformation products in surface water by electrochemical oxidation in short reaction times. An evaluation of the effects of current density, chloride concentrations, and pH on the electrochemical oxidation process (mechanisms, kinetics, and reaction times) was conducted. Results showed that degradation rates of naproxen were greater, and the reaction times were shorter than those reported in other studies for other compounds and electrode materials. Oxidation naproxen and its transformation products were faster at high current densities, high chloride concentrations, and low pH conditions; however, good performance of the electrochemical oxidation process was observed at 16.3 mA/cm2 and pH 5 for both the naproxen and its transformation products, which were oxidized in only 15 min for the treated effluent and 30 min in the case of sludge. At pH 3 and 5, the number of transformation products and the reaction times required for achieving complete oxidation were greater in sludge than in the treated effluent; meanwhile, at pH 7 and 9, the number of transformation products and reaction times needed for non-detection were of the same order in both the treated effluent and the sludge.
Total publications
22
Total citations
236
Citations per publication
10.73
Average publications per year
2.2
Average coauthors
3.91
Publications years
2015-2024 (10 years)
h-index
10
i10-index
10
m-index
1
o-index
17
g-index
15
w-index
2
Metrics description
h-index
A scientist has an h-index if h of his N publications are cited at least h times each, while the remaining (N - h) publications are cited no more than h times each.
i10-index
The number of the author's publications that received at least 10 links each.
m-index
The researcher's m-index is numerically equal to the ratio of his h-index to the number of years that have passed since the first publication.
o-index
The geometric mean of the h-index and the number of citations of the most cited article of the scientist.
g-index
For a given set of articles, sorted in descending order of the number of citations that these articles received, the g-index is the largest number such that the g most cited articles received (in total) at least g2 citations.
w-index
If w articles of a researcher have at least 10w citations each and other publications are less than 10(w+1) citations, then the researcher's w-index is equal to w.
Top-100
Fields of science
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Analytical Chemistry
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Analytical Chemistry, 16, 72.73%
Analytical Chemistry
16 publications, 72.73%
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Electrochemistry
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Electrochemistry, 6, 27.27%
Electrochemistry
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General Chemical Engineering
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Materials Chemistry
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General Chemistry
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General Chemistry, 2, 9.09%
General Chemistry
2 publications, 9.09%
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Catalysis
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Catalysis, 2, 9.09%
Catalysis
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Organic Chemistry
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Organic Chemistry, 2, 9.09%
Organic Chemistry
2 publications, 9.09%
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Drug Discovery
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Drug Discovery, 1, 4.55%
Drug Discovery
1 publication, 4.55%
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Spectroscopy
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Spectroscopy, 1, 4.55%
Spectroscopy
1 publication, 4.55%
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Pharmacology
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Pharmacology, 1, 4.55%
Pharmacology
1 publication, 4.55%
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Journal of Analytical Chemistry
8 publications, 36.36%
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Analitika i Kontrol
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Citing journals
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Journal of Analytical Chemistry
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Microchemical Journal
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Mendeleev Communications
6 citations, 2.54%
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Chirality
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Polymer Science - Series B
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Small
1 citation, 0.42%
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Nanomaterials
1 citation, 0.42%
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1 citation, 0.42%
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1 citation, 0.42%
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1 citation, 0.42%
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1 citation, 0.42%
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1 citation, 0.42%
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1 citation, 0.42%
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Fullerenes Nanotubes and Carbon Nanostructures
1 citation, 0.42%
|
|
Journal of Electronic Materials
1 citation, 0.42%
|
|
Petroleum Chemistry
1 citation, 0.42%
|
|
Food Chemistry
1 citation, 0.42%
|
|
Heliyon
1 citation, 0.42%
|
|
Reviews in Analytical Chemistry
1 citation, 0.42%
|
|
Analytical Biochemistry
1 citation, 0.42%
|
|
ACS Symposium Series
1 citation, 0.42%
|
|
Chemistry - A European Journal
1 citation, 0.42%
|
|
Журнал Общей Химии
1 citation, 0.42%
|
|
Separation Science Plus
1 citation, 0.42%
|
|
Show all (38 more) | |
5
10
15
20
25
30
35
40
45
50
|
Publishers
1
2
3
4
5
6
7
8
9
|
|
Pleiades Publishing
9 publications, 40.91%
|
|
Ural Federal University
5 publications, 22.73%
|
|
Elsevier
4 publications, 18.18%
|
|
Wiley
2 publications, 9.09%
|
|
Bentham Science Publishers Ltd.
1 publication, 4.55%
|
|
Royal Society of Chemistry (RSC)
1 publication, 4.55%
|
|
1
2
3
4
5
6
7
8
9
|
Organizations from articles
5
10
15
20
25
|
|
Ufa University of Science and Technology
21 publications, 95.45%
|
|
Ufa Institute of Chemistry of the Ufa Federal Research Center of the Russian Academy of Sciences
4 publications, 18.18%
|
|
Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences
3 publications, 13.64%
|
|
M. Akmullah Bashkir State Pedagogical University
2 publications, 9.09%
|
|
Organization not defined
|
Organization not defined, 1, 4.55%
Organization not defined
1 publication, 4.55%
|
Kazan Federal University
1 publication, 4.55%
|
|
Kazan National Research Technical University named after A. N. Tupolev - KAI
1 publication, 4.55%
|
|
Ufa Federal Research Center of the Russian Academy of Sciences
1 publication, 4.55%
|
|
5
10
15
20
25
|
Countries from articles
5
10
15
20
25
|
|
Russia
|
Russia, 21, 95.45%
Russia
21 publications, 95.45%
|
Country not defined
|
Country not defined, 1, 4.55%
Country not defined
1 publication, 4.55%
|
Republic of Korea
|
Republic of Korea, 1, 4.55%
Republic of Korea
1 publication, 4.55%
|
5
10
15
20
25
|
Citing organizations
5
10
15
20
25
30
35
40
|
|
Ufa University of Science and Technology
38 citations, 16.1%
|
|
Organization not defined
|
Organization not defined, 28, 11.86%
Organization not defined
28 citations, 11.86%
|
Ufa Institute of Chemistry of the Ufa Federal Research Center of the Russian Academy of Sciences
10 citations, 4.24%
|
|
Lomonosov Moscow State University
5 citations, 2.12%
|
|
Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences
5 citations, 2.12%
|
|
Kazan Federal University
5 citations, 2.12%
|
|
A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences
4 citations, 1.69%
|
|
Kazan National Research Technical University named after A. N. Tupolev - KAI
4 citations, 1.69%
|
|
Changzhou University
4 citations, 1.69%
|
|
Lanzhou University of Technology
3 citations, 1.27%
|
|
Mansoura University
3 citations, 1.27%
|
|
Voronezh State University
2 citations, 0.85%
|
|
Chuvash State University
2 citations, 0.85%
|
|
M. Akmullah Bashkir State Pedagogical University
2 citations, 0.85%
|
|
Ufa Federal Research Center of the Russian Academy of Sciences
2 citations, 0.85%
|
|
University of Tehran
2 citations, 0.85%
|
|
Shanmugha Arts, Science, Technology & Research Academy
2 citations, 0.85%
|
|
Islamic Azad University, Amol Branch
2 citations, 0.85%
|
|
Central South University
2 citations, 0.85%
|
|
Istituto Superiore di Sanità
2 citations, 0.85%
|
|
University of Michigan
2 citations, 0.85%
|
|
Al-Azhar University
2 citations, 0.85%
|
|
Sohag University
2 citations, 0.85%
|
|
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
1 citation, 0.42%
|
|
N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences
1 citation, 0.42%
|
|
Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
1 citation, 0.42%
|
|
Ural Federal University
1 citation, 0.42%
|
|
Peoples' Friendship University of Russia
1 citation, 0.42%
|
|
Saratov State University
1 citation, 0.42%
|
|
Ufa State Petroleum Technological University
1 citation, 0.42%
|
|
Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences
1 citation, 0.42%
|
|
Research Station of the Russian Academy of Sciences in Bishkek
1 citation, 0.42%
|
|
King Saud University
1 citation, 0.42%
|
|
University of Tabuk
1 citation, 0.42%
|
|
Shiraz University of Medical Sciences
1 citation, 0.42%
|
|
United Arab Emirates University
1 citation, 0.42%
|
|
Panjab University
1 citation, 0.42%
|
|
University of Tabriz
1 citation, 0.42%
|
|
University of Mohaghegh Ardabili
1 citation, 0.42%
|
|
Quaid-i-Azam University
1 citation, 0.42%
|
|
Indian Institute of Technology Guwahati
1 citation, 0.42%
|
|
Bharathidasan University
1 citation, 0.42%
|
|
Payame Noor University
1 citation, 0.42%
|
|
Islamic Azad University, Tehran
1 citation, 0.42%
|
|
Qaemshahr Islamic Azad University
1 citation, 0.42%
|
|
Christ University
1 citation, 0.42%
|
|
Necmettin Erbakan University
1 citation, 0.42%
|
|
Maharshi Dayanand University
1 citation, 0.42%
|
|
Bu-Ali Sina University
1 citation, 0.42%
|
|
Sichuan University
1 citation, 0.42%
|
|
University Putra Malaysia
1 citation, 0.42%
|
|
Monash University Malaysia
1 citation, 0.42%
|
|
University of Bordeaux
1 citation, 0.42%
|
|
China Pharmaceutical University
1 citation, 0.42%
|
|
Chongqing Medical University
1 citation, 0.42%
|
|
Southwest University
1 citation, 0.42%
|
|
Hebei University
1 citation, 0.42%
|
|
Dalian Ocean University
1 citation, 0.42%
|
|
Polytechnic University of Milan
1 citation, 0.42%
|
|
University of Milan
1 citation, 0.42%
|
|
University of Liverpool
1 citation, 0.42%
|
|
University of Science and Technology Liaoning
1 citation, 0.42%
|
|
University of Southern Denmark
1 citation, 0.42%
|
|
Roskilde University
1 citation, 0.42%
|
|
Xi'an Jiaotong–Liverpool University
1 citation, 0.42%
|
|
University of Edinburgh
1 citation, 0.42%
|
|
Manchester Metropolitan University
1 citation, 0.42%
|
|
Huaqiao University
1 citation, 0.42%
|
|
Guizhou University
1 citation, 0.42%
|
|
Cairo University
1 citation, 0.42%
|
|
University of Messina
1 citation, 0.42%
|
|
Shaanxi University of Science and Technology
1 citation, 0.42%
|
|
University of Insubria
1 citation, 0.42%
|
|
Regina Elena National Cancer Institute
1 citation, 0.42%
|
|
Murdoch University
1 citation, 0.42%
|
|
Durban University of Technology
1 citation, 0.42%
|
|
Hanyang University
1 citation, 0.42%
|
|
Yeungnam University
1 citation, 0.42%
|
|
Changsha Medical University
1 citation, 0.42%
|
|
Lanzhou University
1 citation, 0.42%
|
|
Northwest Normal University
1 citation, 0.42%
|
|
Lanzhou Jiaotong University
1 citation, 0.42%
|
|
Lanzhou City University
1 citation, 0.42%
|
|
Jiangxi Science and Technology Normal University
1 citation, 0.42%
|
|
Guilin University of Technology
1 citation, 0.42%
|
|
University of Vienna
1 citation, 0.42%
|
|
University of Monastir
1 citation, 0.42%
|
|
University of Coimbra
1 citation, 0.42%
|
|
Zagazig University
1 citation, 0.42%
|
|
Medical University of Warsaw
1 citation, 0.42%
|
|
University of Warsaw
1 citation, 0.42%
|
|
Benha University
1 citation, 0.42%
|
|
Assiut University
1 citation, 0.42%
|
|
Menoufia University
1 citation, 0.42%
|
|
Egyptian Russian University
1 citation, 0.42%
|
|
Show all (65 more) | |
5
10
15
20
25
30
35
40
|
Citing countries
10
20
30
40
50
60
|
|
Russia
|
Russia, 60, 25.42%
Russia
60 citations, 25.42%
|
Country not defined
|
Country not defined, 18, 7.63%
Country not defined
18 citations, 7.63%
|
China
|
China, 18, 7.63%
China
18 citations, 7.63%
|
Egypt
|
Egypt, 10, 4.24%
Egypt
10 citations, 4.24%
|
India
|
India, 9, 3.81%
India
9 citations, 3.81%
|
Iran
|
Iran, 9, 3.81%
Iran
9 citations, 3.81%
|
Italy
|
Italy, 4, 1.69%
Italy
4 citations, 1.69%
|
France
|
France, 3, 1.27%
France
3 citations, 1.27%
|
Brazil
|
Brazil, 3, 1.27%
Brazil
3 citations, 1.27%
|
Republic of Korea
|
Republic of Korea, 3, 1.27%
Republic of Korea
3 citations, 1.27%
|
USA
|
USA, 2, 0.85%
USA
2 citations, 0.85%
|
Portugal
|
Portugal, 2, 0.85%
Portugal
2 citations, 0.85%
|
United Kingdom
|
United Kingdom, 2, 0.85%
United Kingdom
2 citations, 0.85%
|
Poland
|
Poland, 2, 0.85%
Poland
2 citations, 0.85%
|
Saudi Arabia
|
Saudi Arabia, 2, 0.85%
Saudi Arabia
2 citations, 0.85%
|
Australia
|
Australia, 1, 0.42%
Australia
1 citation, 0.42%
|
Austria
|
Austria, 1, 0.42%
Austria
1 citation, 0.42%
|
Denmark
|
Denmark, 1, 0.42%
Denmark
1 citation, 0.42%
|
Kyrgyzstan
|
Kyrgyzstan, 1, 0.42%
Kyrgyzstan
1 citation, 0.42%
|
Malaysia
|
Malaysia, 1, 0.42%
Malaysia
1 citation, 0.42%
|
UAE
|
UAE, 1, 0.42%
UAE
1 citation, 0.42%
|
Oman
|
Oman, 1, 0.42%
Oman
1 citation, 0.42%
|
Pakistan
|
Pakistan, 1, 0.42%
Pakistan
1 citation, 0.42%
|
Romania
|
Romania, 1, 0.42%
Romania
1 citation, 0.42%
|
Thailand
|
Thailand, 1, 0.42%
Thailand
1 citation, 0.42%
|
Tunisia
|
Tunisia, 1, 0.42%
Tunisia
1 citation, 0.42%
|
Turkey
|
Turkey, 1, 0.42%
Turkey
1 citation, 0.42%
|
Czech Republic
|
Czech Republic, 1, 0.42%
Czech Republic
1 citation, 0.42%
|
South Africa
|
South Africa, 1, 0.42%
South Africa
1 citation, 0.42%
|
10
20
30
40
50
60
|
- We do not take into account publications without a DOI.
- Statistics recalculated daily.
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Company/Organization
Position
Associate Professor of the Department of Analytical Chemistry
Employment type
Full time
Years
2021 —
present
Company/Organization
Position
Senior researcher
Employment type
Part time
Years
2021 —
present