Biochemistry (Moscow), volume 85, issue 4, pages 425-435
Translesion DNA Synthesis and Carcinogenesis
Shilkin E S
1
,
Boldinova E O
1
,
Stolyarenko A D
1
,
Goncharova R. I.
2
,
Chuprov-Netochin R. N.
3
,
Khairullin R F
4
,
Smal M P
2
,
3
Moscow Institute of Physics and Technolog, Dolgoprudny, Russia
|
Publication type: Journal Article
Publication date: 2020-04-27
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Biophysics
Geriatrics and Gerontology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Abstract
Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA template structure and efficiently incorporate nucleotides opposite DNA lesions. However, these polymerases display low accuracy of DNA synthesis and can introduce mutations in genomic DNA. Impaired functioning of these enzymes can lead to an increased risk of cancer.
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Citations by publishers
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1
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Frontiers Media S.A.
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1 publication, 20%
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Oxford University Press
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Oxford University Press
1 publication, 20%
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Wiley
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Wiley
1 publication, 20%
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Taylor & Francis
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1 publication, 20%
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Shilkin E. S. et al. Translesion DNA Synthesis and Carcinogenesis // Biochemistry (Moscow). 2020. Vol. 85. No. 4. pp. 425-435.
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Shilkin E. S., Boldinova E. O., Stolyarenko A. D., Goncharova R. I., Chuprov-Netochin R. N., Khairullin R. F., Smal M. P., Makarova A. V. Translesion DNA Synthesis and Carcinogenesis // Biochemistry (Moscow). 2020. Vol. 85. No. 4. pp. 425-435.
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RIS
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TY - JOUR
DO - 10.1134/s0006297920040033
UR - https://doi.org/10.1134%2Fs0006297920040033
TI - Translesion DNA Synthesis and Carcinogenesis
T2 - Biochemistry (Moscow)
AU - Shilkin, E S
AU - Boldinova, E O
AU - Stolyarenko, A D
AU - Goncharova, R. I.
AU - Chuprov-Netochin, R. N.
AU - Khairullin, R F
AU - Smal, M P
AU - Makarova, A. V.
PY - 2020
DA - 2020/04/27 00:00:00
PB - Pleiades Publishing
SP - 425-435
IS - 4
VL - 85
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2020_Shilkin,
author = {E S Shilkin and E O Boldinova and A D Stolyarenko and R. I. Goncharova and R. N. Chuprov-Netochin and R F Khairullin and M P Smal and A. V. Makarova},
title = {Translesion DNA Synthesis and Carcinogenesis},
journal = {Biochemistry (Moscow)},
year = {2020},
volume = {85},
publisher = {Pleiades Publishing},
month = {apr},
url = {https://doi.org/10.1134%2Fs0006297920040033},
number = {4},
pages = {425--435},
doi = {10.1134/s0006297920040033}
}
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MLA
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Shilkin, E. S., et al. “Translesion DNA Synthesis and Carcinogenesis.” Biochemistry (Moscow), vol. 85, no. 4, Apr. 2020, pp. 425-435. https://doi.org/10.1134%2Fs0006297920040033.