Biochemistry (Moscow)

, volume 85 , issue 4 , pages 425-435

Translesion DNA Synthesis and Carcinogenesis

E S Shilkin ¹

E O Boldinova ¹

A D Stolyarenko ¹

R. I. Goncharova ²

R. N. Chuprov-Netochin ³

R F Khairullin ⁴

M P Smal ²

A. V. Makarova ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Institute of Molecular genetics, Russian Academy of Sciences, Moscow, Russia |

Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk, Republic of Belarus |

Moscow Institute of Physics and Technolog, Dolgoprudny, Russia |

⁴

Institute of Fundamental Medicine and Biology, Kazan (Volga region) Federal University, Kazan, Russia |

Publication type: Journal Article

Publication date: 2020-04-27

Pleiades Publishing

Biochemistry (Moscow)

scimago Q2

wos Q4

SJR: 0.659

CiteScore: 3.8

Impact factor: 2.2

ISSN: 00062979, 16083040

DOI: 10.1134/s0006297920040033

Copy DOI

PubMed ID: 32569550

Biochemistry

General Medicine

Biophysics

Geriatrics and Gerontology

Biochemistry, Genetics and Molecular Biology (miscellaneous)

Abstract

Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA template structure and efficiently incorporate nucleotides opposite DNA lesions. However, these polymerases display low accuracy of DNA synthesis and can introduce mutations in genomic DNA. Impaired functioning of these enzymes can lead to an increased risk of cancer.

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GOST |

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GOST Copy

Shilkin E. S. et al. Translesion DNA Synthesis and Carcinogenesis // Biochemistry (Moscow). 2020. Vol. 85. No. 4. pp. 425-435.

GOST all authors (up to 50) Copy

Shilkin E. S., Boldinova E. O., Stolyarenko A. D., Goncharova R. I., Chuprov-Netochin R. N., Khairullin R. F., Smal M. P., Makarova A. V. Translesion DNA Synthesis and Carcinogenesis // Biochemistry (Moscow). 2020. Vol. 85. No. 4. pp. 425-435.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1134/s0006297920040033

UR - https://doi.org/10.1134/s0006297920040033

TI - Translesion DNA Synthesis and Carcinogenesis

T2 - Biochemistry (Moscow)

AU - Shilkin, E S

AU - Boldinova, E O

AU - Stolyarenko, A D

AU - Goncharova, R. I.

AU - Chuprov-Netochin, R. N.

AU - Khairullin, R F

AU - Smal, M P

AU - Makarova, A. V.

PY - 2020

DA - 2020/04/27

PB - Pleiades Publishing

SP - 425-435

IS - 4

VL - 85

PMID - 32569550

SN - 0006-2979

SN - 1608-3040

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Shilkin,

author = {E S Shilkin and E O Boldinova and A D Stolyarenko and R. I. Goncharova and R. N. Chuprov-Netochin and R F Khairullin and M P Smal and A. V. Makarova},

title = {Translesion DNA Synthesis and Carcinogenesis},

journal = {Biochemistry (Moscow)},

year = {2020},

volume = {85},

publisher = {Pleiades Publishing},

month = {apr},

url = {https://doi.org/10.1134/s0006297920040033},

number = {4},

pages = {425--435},

doi = {10.1134/s0006297920040033}

}

MLA

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MLA Copy

Shilkin, E. S., et al. “Translesion DNA Synthesis and Carcinogenesis.” Biochemistry (Moscow), vol. 85, no. 4, Apr. 2020, pp. 425-435. https://doi.org/10.1134/s0006297920040033.

Publisher

Pleiades Publishing

Journal

Biochemistry (Moscow)

scimago Q2

wos Q4

SJR

0.659

CiteScore

3.8

Impact factor

2.2

ISSN

00062979 (Print)

16083040 (Electronic)

Labs

Laboratory of mechanisms of replication of damaged DNA

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