Role of YB-1 Protein in Inflammation
Publication type: Journal Article
Publication date: 2022-01-31
scimago Q2
wos Q4
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
PubMed ID:
35501989
Biochemistry
General Medicine
Biophysics
Geriatrics and Gerontology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Abstract
This review discusses the role of the multifunctional DNA/RNA-binding protein YB-1 in inflammation. YB-1 performs multiple functions in the cell depending on its location: it acts as transcriptional factor for many genes in the nucleus, regulates translation and stability of mRNA in the cytoplasm, and becomes a paracrine factor when secreted from the cells. The review presents the data on the YB-1-mediated regulation of inflammation-associated genes, as well as results of studies on the YB-1 role in animal model of various inflammatory diseases, such as glomerulonephritis, tubulointerstitial fibrosis, and bacterial sepsis, and on the YB-1 expression in different human diseases associated with inflammatory processes in kidney, liver, and endometrium. The last section of the review presents several approaches to the regulation of YB-1 with small molecules in the treatment of inflammatory diseases.
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12
Total citations:
12
Citations from 2024:
8
(66%)
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MLA
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GOST
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Rybalkina E. Yu., Moiseeva N. I. Role of YB-1 Protein in Inflammation // Biochemistry (Moscow). 2022. Vol. 87. No. S1. p. S94-S102.
GOST all authors (up to 50)
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Rybalkina E. Yu., Moiseeva N. I. Role of YB-1 Protein in Inflammation // Biochemistry (Moscow). 2022. Vol. 87. No. S1. p. S94-S102.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/s0006297922140085
UR - https://doi.org/10.1134/s0006297922140085
TI - Role of YB-1 Protein in Inflammation
T2 - Biochemistry (Moscow)
AU - Rybalkina, Ekaterina Yu
AU - Moiseeva, Natalia I
PY - 2022
DA - 2022/01/31
PB - Pleiades Publishing
SP - S94-S102
IS - S1
VL - 87
PMID - 35501989
SN - 0006-2979
SN - 1608-3040
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Rybalkina,
author = {Ekaterina Yu Rybalkina and Natalia I Moiseeva},
title = {Role of YB-1 Protein in Inflammation},
journal = {Biochemistry (Moscow)},
year = {2022},
volume = {87},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/s0006297922140085},
number = {S1},
pages = {S94--S102},
doi = {10.1134/s0006297922140085}
}
Cite this
MLA
Copy
Rybalkina, Ekaterina Yu., and Natalia I Moiseeva. “Role of YB-1 Protein in Inflammation.” Biochemistry (Moscow), vol. 87, no. S1, Jan. 2022, pp. S94-S102. https://doi.org/10.1134/s0006297922140085.
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