Journal of Analytical Chemistry, volume 75, issue 12, pages 1537-1545
A Voltammetric Sensor Based on a 3,4,9,10-Perylenetetracarboxylic Acid Composite for the Recognition and Determination of Tyrosine Enantiomers
Yu A Yarkaeva
1
,
D I Dubrovskii
1
,
R A Zilberg
1
,
V N Maistrenko
1
,
V.M. Kornilov
2
Publication type: Journal Article
Publication date: 2020-12-19
Journal:
Journal of Analytical Chemistry
scimago Q3
wos Q4
SJR: 0.242
CiteScore: 2.1
Impact factor: 1
ISSN: 10619348, 16083199
Analytical Chemistry
Abstract
An enantioselective voltammetric sensor based on a glassy carbon electrode modified with a composite of a polyelectrolyte complex of chitosan, Carboblack C graphitized thermal carbon black, and 3,4,9,10-perylenetetracarboxylic acid is developed for the recognition and determination of tyrosine enantiomers. The enantioselectivity of the sensor is due to the formation of self-organizing chiral nanoclusters of 3,4,9,10-perylenetetracarboxylic acid. The electrochemical and analytical characteristics of the sensor are studied. The proposed sensor is used to recognize and determine L- and D-enantiomers of tyrosine in samples of urine and human blood plasma, as well as in a mixture. To increase the probability of the recognition of tyrosine enantiomers in determining them in a mixture, the chemometric method of projection to latent structures is used. It is shown that the proposed sensor ensures the determination of the ratio of L- and D-enantiomers of tyrosine in a mixture with a high probability and a relative error of less than 8%.
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