Pleiades Publishing
Biochemistry (Moscow)
,  volume 74 ,  issue 1 ,  pages 92-96

Replication protein A modulates the activity of human telomerase in vitro

Publication type: Journal Article
Publication date: 2009-01-01
Pleiades Publishing
scimago Q2
wos Q4
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
Our aim was to investigate how replication protein A (RPA) in a wide range of concentration can regulate the activity of human telomerase. We used an in vitro system based on human cell extracts with or without RPA. It has been shown that removal of RPA leads to loss of telomerase activity and addition of RPA restores telomerase activity and at the same time promotes telomerase processivity. However, high excess of RPA inhibited telomerase processivity and caused the synthesis of relatively short DNA fragments (about 50–100 nucleotides). We assume that, together with other telomere-binding proteins, RPA may take part in activation of telomere overhang elongation by telomerase at a certain stage of a cell cycle as well as in regulation of telomere length.
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GOST Copy
Rubtsova M. P. et al. Replication protein A modulates the activity of human telomerase in vitro // Biochemistry (Moscow). 2009. Vol. 74. No. 1. pp. 92-96.
GOST all authors (up to 50) Copy
Rubtsova M. P., Skvortsov D. A., Petruseva I. O., Lavrik O. I., Spirin P. V., Prasolov V. S., Kisseljov F. L., Dontsova O. A. Replication protein A modulates the activity of human telomerase in vitro // Biochemistry (Moscow). 2009. Vol. 74. No. 1. pp. 92-96.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/S0006297909010143
UR - http://link.springer.com/10.1134/S0006297909010143
TI - Replication protein A modulates the activity of human telomerase in vitro
T2 - Biochemistry (Moscow)
AU - Rubtsova, M. P.
AU - Skvortsov, D A
AU - Petruseva, I O
AU - Lavrik, O I
AU - Spirin, P. V.
AU - Prasolov, V S
AU - Kisseljov, F L
AU - Dontsova, O. A.
PY - 2009
DA - 2009/01/01
PB - Pleiades Publishing
SP - 92-96
IS - 1
VL - 74
PMID - 19232055
SN - 0006-2979
SN - 1608-3040
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2009_Rubtsova,
author = {M. P. Rubtsova and D A Skvortsov and I O Petruseva and O I Lavrik and P. V. Spirin and V S Prasolov and F L Kisseljov and O. A. Dontsova},
title = {Replication protein A modulates the activity of human telomerase in vitro},
journal = {Biochemistry (Moscow)},
year = {2009},
volume = {74},
publisher = {Pleiades Publishing},
month = {jan},
url = {http://link.springer.com/10.1134/S0006297909010143},
number = {1},
pages = {92--96},
doi = {10.1134/S0006297909010143}
}
MLA
Cite this
MLA Copy
Rubtsova, M. P., et al. “Replication protein A modulates the activity of human telomerase in vitro.” Biochemistry (Moscow), vol. 74, no. 1, Jan. 2009, pp. 92-96. http://link.springer.com/10.1134/S0006297909010143.