Biochemistry (Moscow)

, том 74 , издание 1 , страницы 92-96

Replication protein A modulates the activity of human telomerase in vitro

M. P. Rubtsova ¹

D A Skvortsov ¹

I O Petruseva ²

O I Lavrik ²

P. V. Spirin ³

V S Prasolov ³

F L Kisseljov ⁴

O. A. Dontsova ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 4 аффилиации

Chemical Faculty, Lomonosov Moscow State University, Moscow, Russia |

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia |

Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia |

⁴

Blokhin Cancer research center, Russian Academy of Medical Sciences, Moscow, Russia |

Тип публикации: Journal Article

Дата публикации: 2009-01-01

Pleiades Publishing

Biochemistry (Moscow)

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SJR: 0.659

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ISSN: 00062979, 16083040

DOI: 10.1134/S0006297909010143

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PubMed ID: 19232055

Biochemistry

General Medicine

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Our aim was to investigate how replication protein A (RPA) in a wide range of concentration can regulate the activity of human telomerase. We used an in vitro system based on human cell extracts with or without RPA. It has been shown that removal of RPA leads to loss of telomerase activity and addition of RPA restores telomerase activity and at the same time promotes telomerase processivity. However, high excess of RPA inhibited telomerase processivity and caused the synthesis of relatively short DNA fragments (about 50–100 nucleotides). We assume that, together with other telomere-binding proteins, RPA may take part in activation of telomere overhang elongation by telomerase at a certain stage of a cell cycle as well as in regulation of telomere length.

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Rubtsova M. P. et al. Replication protein A modulates the activity of human telomerase in vitro // Biochemistry (Moscow). 2009. Vol. 74. No. 1. pp. 92-96.

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Rubtsova M. P., Skvortsov D. A., Petruseva I. O., Lavrik O. I., Spirin P. V., Prasolov V. S., Kisseljov F. L., Dontsova O. A. Replication protein A modulates the activity of human telomerase in vitro // Biochemistry (Moscow). 2009. Vol. 74. No. 1. pp. 92-96.

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TY - JOUR

DO - 10.1134/S0006297909010143

UR - http://link.springer.com/10.1134/S0006297909010143

TI - Replication protein A modulates the activity of human telomerase in vitro

T2 - Biochemistry (Moscow)

AU - Rubtsova, M. P.

AU - Skvortsov, D A

AU - Petruseva, I O

AU - Lavrik, O I

AU - Spirin, P. V.

AU - Prasolov, V S

AU - Kisseljov, F L

AU - Dontsova, O. A.

PY - 2009

DA - 2009/01/01

PB - Pleiades Publishing

SP - 92-96

IS - 1

VL - 74

PMID - 19232055

SN - 0006-2979

SN - 1608-3040

ER -

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@article{2009_Rubtsova,

author = {M. P. Rubtsova and D A Skvortsov and I O Petruseva and O I Lavrik and P. V. Spirin and V S Prasolov and F L Kisseljov and O. A. Dontsova},

title = {Replication protein A modulates the activity of human telomerase in vitro},

journal = {Biochemistry (Moscow)},

year = {2009},

volume = {74},

publisher = {Pleiades Publishing},

month = {jan},

url = {http://link.springer.com/10.1134/S0006297909010143},

number = {1},

pages = {92--96},

doi = {10.1134/S0006297909010143}

}

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Rubtsova, M. P., et al. “Replication protein A modulates the activity of human telomerase in vitro.” Biochemistry (Moscow), vol. 74, no. 1, Jan. 2009, pp. 92-96. http://link.springer.com/10.1134/S0006297909010143.