Biochemistry (Moscow), volume 75, issue 13, pages 1563-1583

Telomerase: Structure, functions, and activity regulation

Zvereva M I

Shcherbakova D M

Dontsova O. A.

Publication type: Journal Article

Publication date: 2010-12-01

Pleiades Publishing

Journal: Biochemistry (Moscow)

Quartile SCImago

Quartile WOS

Impact factor: 2.8

ISSN: 00062979, 16083040

DOI: 10.1134/S0006297910130055

Copy DOI

Biochemistry

General Medicine

Abstract

Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes and stem and tumor cells. In human somatic cells proliferation potential is strictly limited and senescence follows approximately 50–70 cell divisions. In most tumor cells, on the contrary, replication potential is unlimited. The key role in this process of the system of the telomere length maintenance with involvement of telomerase is still poorly studied. No doubt, DNA polymerase is not capable to completely copy DNA at the very ends of chromosomes; therefore, approximately 50 nucleotides are lost during each cell cycle, which results in gradual telomere length shortening. Critically short telomeres cause senescence, following crisis, and cell death. However, in tumor cells the system of telomere length maintenance is activated. Besides catalytic telomere elongation, independent telomerase functions can be also involved in cell cycle regulation. Inhibition of the telomerase catalytic function and resulting cessation of telomere length maintenance will help in restriction of tumor cell replication potential. On the other hand, formation of temporarily active enzyme via its intracellular activation or due to stimulation of expression of telomerase components will result in telomerase activation and telomere elongation that can be used for correction of degenerative changes. Data on telomerase structure and function are summarized in this review, and they are compared for evolutionarily remote organisms. Problems of telomerase activity measurement and modulation by enzyme inhibitors or activators are considered as well.

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The Company of Biologists	The Company of Biologists, 1, 0.85% The Company of Biologists 1 publication, 0.85%
	5 10 15 20 25

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Zvereva M. I., Shcherbakova D. M., Dontsova O. A. Telomerase: Structure, functions, and activity regulation // Biochemistry (Moscow). 2010. Vol. 75. No. 13. pp. 1563-1583.

GOST all authors (up to 50) Copy

Zvereva M. I., Shcherbakova D. M., Dontsova O. A. Telomerase: Structure, functions, and activity regulation // Biochemistry (Moscow). 2010. Vol. 75. No. 13. pp. 1563-1583.

RIS |

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TY - JOUR

DO - 10.1134/S0006297910130055

UR - https://doi.org/10.1134%2FS0006297910130055

TI - Telomerase: Structure, functions, and activity regulation

T2 - Biochemistry (Moscow)

AU - Zvereva, M I

AU - Shcherbakova, D M

AU - Dontsova, O. A.

PY - 2010

DA - 2010/12/01 00:00:00

PB - Pleiades Publishing

SP - 1563-1583

IS - 13

VL - 75

SN - 0006-2979

SN - 1608-3040

ER -

BibTex |

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BibTex Copy

@article{2010_Zvereva,

author = {M I Zvereva and D M Shcherbakova and O. A. Dontsova},

title = {Telomerase: Structure, functions, and activity regulation},

journal = {Biochemistry (Moscow)},

year = {2010},

volume = {75},

publisher = {Pleiades Publishing},

month = {dec},

url = {https://doi.org/10.1134%2FS0006297910130055},

number = {13},

pages = {1563--1583},

doi = {10.1134/S0006297910130055}

}

MLA

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MLA Copy

Zvereva, M. I., et al. “Telomerase: Structure, functions, and activity regulation.” Biochemistry (Moscow), vol. 75, no. 13, Dec. 2010, pp. 1563-1583. https://doi.org/10.1134%2FS0006297910130055.

Found error?

Publisher

Pleiades Publishing

Journal

Biochemistry (Moscow)

Quartile SCImago

Quartile WOS

Impact factor

2.8

ISSN

00062979 (Print)
16083040 (Electronic)

Labs

Laboratory of Nucleoprotein Chemistry, Department of Chemistry of Natural Compounds, Faculty of Chemistry

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