Telomerase RNA biosynthesis and processing
Publication type: Journal Article
Publication date: 2012-10-17
scimago Q2
wos Q4
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
PubMed ID:
23157292
Biochemistry
General Medicine
Abstract
Telomerase synthesizes repetitive G-rich sequences (telomeric repeats) at the ends of eukaryotic chromosomes. This mechanism maintains the integrity of the genome, as telomere shortening leads to degradation and fusion of chromosomes. The core components of telomerase are the telomerase catalytic subunit and telomerase RNA, which possesses a small template region serving for the synthesis of a telomeric repeat. Mutations in the telomerase RNA are associated with some cases of aplastic anemia and also cause dyskeratosis congenita, myelodysplasia, and pulmonary fibrosis. Telomerase is active in 85% of cancers, and telomerase activation is one of the first steps in cell transformation. The study of telomerase and pathways where this enzyme is involved will help to understand the mechanism of the mentioned diseases and to develop new approaches for their treatment. In this review we describe the modern conception of telomerase RNA biosynthesis, processing, and functioning in the three most studied systems — yeast, vertebrates, and ciliates.
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GOST
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Smekalova E. M. et al. Telomerase RNA biosynthesis and processing // Biochemistry (Moscow). 2012. Vol. 77. No. 10. pp. 1120-1128.
GOST all authors (up to 50)
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Smekalova E. M., Shubernetskaya O. S., Zvereva M. I., Gromenko E. V., Rubtsova M. P., Dontsova O. A. Telomerase RNA biosynthesis and processing // Biochemistry (Moscow). 2012. Vol. 77. No. 10. pp. 1120-1128.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S0006297912100045
UR - http://link.springer.com/10.1134/S0006297912100045
TI - Telomerase RNA biosynthesis and processing
T2 - Biochemistry (Moscow)
AU - Smekalova, E M
AU - Shubernetskaya, O S
AU - Zvereva, M I
AU - Gromenko, E V
AU - Rubtsova, M. P.
AU - Dontsova, O. A.
PY - 2012
DA - 2012/10/17
PB - Pleiades Publishing
SP - 1120-1128
IS - 10
VL - 77
PMID - 23157292
SN - 0006-2979
SN - 1608-3040
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Smekalova,
author = {E M Smekalova and O S Shubernetskaya and M I Zvereva and E V Gromenko and M. P. Rubtsova and O. A. Dontsova},
title = {Telomerase RNA biosynthesis and processing},
journal = {Biochemistry (Moscow)},
year = {2012},
volume = {77},
publisher = {Pleiades Publishing},
month = {oct},
url = {http://link.springer.com/10.1134/S0006297912100045},
number = {10},
pages = {1120--1128},
doi = {10.1134/S0006297912100045}
}
Cite this
MLA
Copy
Smekalova, E. M., et al. “Telomerase RNA biosynthesis and processing.” Biochemistry (Moscow), vol. 77, no. 10, Oct. 2012, pp. 1120-1128. http://link.springer.com/10.1134/S0006297912100045.