Biochemistry (Moscow), volume 77, issue 10, pages 1120-1128
Telomerase RNA biosynthesis and processing
Publication type: Journal Article
Publication date: 2012-10-17
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
Telomerase synthesizes repetitive G-rich sequences (telomeric repeats) at the ends of eukaryotic chromosomes. This mechanism maintains the integrity of the genome, as telomere shortening leads to degradation and fusion of chromosomes. The core components of telomerase are the telomerase catalytic subunit and telomerase RNA, which possesses a small template region serving for the synthesis of a telomeric repeat. Mutations in the telomerase RNA are associated with some cases of aplastic anemia and also cause dyskeratosis congenita, myelodysplasia, and pulmonary fibrosis. Telomerase is active in 85% of cancers, and telomerase activation is one of the first steps in cell transformation. The study of telomerase and pathways where this enzyme is involved will help to understand the mechanism of the mentioned diseases and to develop new approaches for their treatment. In this review we describe the modern conception of telomerase RNA biosynthesis, processing, and functioning in the three most studied systems — yeast, vertebrates, and ciliates.
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- We do not take into account publications that without a DOI.
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Smekalova E. M. et al. Telomerase RNA biosynthesis and processing // Biochemistry (Moscow). 2012. Vol. 77. No. 10. pp. 1120-1128.
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Smekalova E. M., Shubernetskaya O. S., Zvereva M. I., Gromenko E. V., Rubtsova M. P., Dontsova O. A. Telomerase RNA biosynthesis and processing // Biochemistry (Moscow). 2012. Vol. 77. No. 10. pp. 1120-1128.
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TY - JOUR
DO - 10.1134/S0006297912100045
UR - https://doi.org/10.1134%2FS0006297912100045
TI - Telomerase RNA biosynthesis and processing
T2 - Biochemistry (Moscow)
AU - Smekalova, E M
AU - Shubernetskaya, O S
AU - Zvereva, M I
AU - Gromenko, E V
AU - Rubtsova, M. P.
AU - Dontsova, O. A.
PY - 2012
DA - 2012/10/17 00:00:00
PB - Pleiades Publishing
SP - 1120-1128
IS - 10
VL - 77
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2012_Smekalova,
author = {E M Smekalova and O S Shubernetskaya and M I Zvereva and E V Gromenko and M. P. Rubtsova and O. A. Dontsova},
title = {Telomerase RNA biosynthesis and processing},
journal = {Biochemistry (Moscow)},
year = {2012},
volume = {77},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.1134%2FS0006297912100045},
number = {10},
pages = {1120--1128},
doi = {10.1134/S0006297912100045}
}
Cite this
MLA
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Smekalova, E. M., et al. “Telomerase RNA biosynthesis and processing.” Biochemistry (Moscow), vol. 77, no. 10, Oct. 2012, pp. 1120-1128. https://doi.org/10.1134%2FS0006297912100045.