Biochemistry (Moscow), volume 80, issue 3, pages 251-259
Oligonucleotide inhibitors of telomerase: Prospects for anticancer therapy and diagnostics
Zvereva M I
1, 2
,
Zatsepin T S
1, 3
,
Azhibek D M
3
,
Shubernetskaya O S
1, 3
,
Shpanchenko O V
1
,
Dontsova O. A.
1, 2
Publication type: Journal Article
Publication date: 2015-03-16
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
The activity of telomerase allows eukaryotic cells to have unlimited division potential. On its functioning, telomerase synthesizes short DNA repeats at the 3′-end of DNA within chromosomes that ensures genome stability during cell division. Telomerase is active in the majority of cancer cell types and is virtually absent in somatic cells with rare exceptions. This difference allows us to consider inhibition of telomerase activity as a possible approach to antitumor therapy. Telomerase is a nucleoprotein composed of two main components: the reverse transcriptase (hTERT), which is a catalytic subunit, and telomerase RNA (hTR), which encodes a template for synthesis of repeats. The biogenesis and features of telomerase seem very promising for its inhibition due to complementary interactions. In this review, we analyze putative pathways of oligonucleotide influence on telomerase and consider the known native and modified oligonucleotide inhibitors of telomerase, as well as possible mechanisms of their action. We also discuss the application of telomerase-targeted oligonucleotide conjugates for in vivo imaging of tumor cells.
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Citations by publishers
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Taylor & Francis
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3 publications, 37.5%
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2 publications, 25%
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1 publication, 12.5%
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1 publication, 12.5%
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American Society for Microbiology
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1 publication, 12.5%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Zvereva M. I. et al. Oligonucleotide inhibitors of telomerase: Prospects for anticancer therapy and diagnostics // Biochemistry (Moscow). 2015. Vol. 80. No. 3. pp. 251-259.
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Zvereva M. I., Zatsepin T. S., Azhibek D. M., Shubernetskaya O. S., Shpanchenko O. V., Dontsova O. A. Oligonucleotide inhibitors of telomerase: Prospects for anticancer therapy and diagnostics // Biochemistry (Moscow). 2015. Vol. 80. No. 3. pp. 251-259.
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TY - JOUR
DO - 10.1134/S0006297915030013
UR - https://doi.org/10.1134%2FS0006297915030013
TI - Oligonucleotide inhibitors of telomerase: Prospects for anticancer therapy and diagnostics
T2 - Biochemistry (Moscow)
AU - Zvereva, M I
AU - Zatsepin, T S
AU - Azhibek, D M
AU - Shubernetskaya, O S
AU - Shpanchenko, O V
AU - Dontsova, O. A.
PY - 2015
DA - 2015/03/16 00:00:00
PB - Pleiades Publishing
SP - 251-259
IS - 3
VL - 80
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2015_Zvereva,
author = {M I Zvereva and T S Zatsepin and D M Azhibek and O S Shubernetskaya and O V Shpanchenko and O. A. Dontsova},
title = {Oligonucleotide inhibitors of telomerase: Prospects for anticancer therapy and diagnostics},
journal = {Biochemistry (Moscow)},
year = {2015},
volume = {80},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134%2FS0006297915030013},
number = {3},
pages = {251--259},
doi = {10.1134/S0006297915030013}
}
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MLA
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Zvereva, M. I., et al. “Oligonucleotide inhibitors of telomerase: Prospects for anticancer therapy and diagnostics.” Biochemistry (Moscow), vol. 80, no. 3, Mar. 2015, pp. 251-259. https://doi.org/10.1134%2FS0006297915030013.
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