The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells
Тип публикации: Journal Article
Дата публикации: 2019-07-13
scimago Q2
wos Q4
БС2
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
PubMed ID:
31509722
Biochemistry
General Medicine
Краткое описание
This review focuses on the structure and molecular action mechanisms of chimeric antigen receptors (CARs) and major aspects of the manufacturing and clinical application of products for the CAR-T (CAR-modified T lymphocyte) therapy of hematological and solid tumors with special emphasis on the strategies for combined use of CAR-T therapy with immuno-oncological monoclonal antibodies (checkpoint inhibitors) and cytokines to boost survival, persistence, and anti-tumor efficacy of CAR-T therapy. The review also summarizes preclinical and clinical data on the additive effects of the combined use of CAR-T therapy with interleukins and monoclonal antibodies targeting immune checkpoints.
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ГОСТ
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Gershovich P. M. et al. The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells // Biochemistry (Moscow). 2019. Vol. 84. No. 7. pp. 695-710.
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Gershovich P. M., Karabelskii A. V., Ulitin A. B., Ivanov R. A. The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells // Biochemistry (Moscow). 2019. Vol. 84. No. 7. pp. 695-710.
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RIS
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TY - JOUR
DO - 10.1134/S0006297919070022
UR - https://doi.org/10.1134/S0006297919070022
TI - The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells
T2 - Biochemistry (Moscow)
AU - Gershovich, P. M.
AU - Karabelskii, A V
AU - Ulitin, A B
AU - Ivanov, R. A.
PY - 2019
DA - 2019/07/13
PB - Pleiades Publishing
SP - 695-710
IS - 7
VL - 84
PMID - 31509722
SN - 0006-2979
SN - 1608-3040
ER -
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BibTex (до 50 авторов)
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@article{2019_Gershovich,
author = {P. M. Gershovich and A V Karabelskii and A B Ulitin and R. A. Ivanov},
title = {The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells},
journal = {Biochemistry (Moscow)},
year = {2019},
volume = {84},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134/S0006297919070022},
number = {7},
pages = {695--710},
doi = {10.1134/S0006297919070022}
}
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MLA
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Gershovich, P. M., et al. “The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell-Based Cancer Immunotherapy with Genetically Modified T Cells.” Biochemistry (Moscow), vol. 84, no. 7, Jul. 2019, pp. 695-710. https://doi.org/10.1134/S0006297919070022.
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