Biochemistry (Moscow)

, volume 85 , issue 11 , pages 1335-1349

rRNA Methylation and Antibiotic Resistance

I A Osterman ^{1, 2}

O. A. Dontsova ^{1, 2, 3}

P V Sergiev ^{1, 2, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, Russia |

Faculty of Chemistry, Lomonosov Moscow State University, Moscow, Russia |

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia |

⁴

Institute of Functional Genomics, Lomonosov Moscow State University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2020-11-26

Pleiades Publishing

Biochemistry (Moscow)

scimago Q2

wos Q4

SJR: 0.659

CiteScore: 3.8

Impact factor: 2.2

ISSN: 00062979, 16083040

DOI: 10.1134/S000629792011005X

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PubMed ID: 33280577

Biochemistry

General Medicine

Abstract

Methylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to protein synthesis inhibitors. The genes for corresponding methyltransferases have been found in producer strains and clinical isolates of pathogenic bacteria. In some cases, rRNA methylation by housekeeping enzymes is, on the contrary, required for the action of antibiotics. The effects of rRNA modifications associated with antibiotic efficacy may be cooperative or mutually exclusive. Evolutionary relationships between the systems of rRNA modification by housekeeping enzymes and antibiotic resistance-related methyltransferases are of particular interest. In this review, we discuss the above topics in detail.

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Kutti Vinothkumar

22 publications, 105 citations

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Tata Institute of Fundamental Research

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GOST |

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GOST Copy

Osterman I. A. et al. rRNA Methylation and Antibiotic Resistance // Biochemistry (Moscow). 2020. Vol. 85. No. 11. pp. 1335-1349.

GOST all authors (up to 50) Copy

Osterman I. A., Dontsova O. A., Sergiev P. V. rRNA Methylation and Antibiotic Resistance // Biochemistry (Moscow). 2020. Vol. 85. No. 11. pp. 1335-1349.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1134/S000629792011005X

UR - http://link.springer.com/10.1134/S000629792011005X

TI - rRNA Methylation and Antibiotic Resistance

T2 - Biochemistry (Moscow)

AU - Osterman, I A

AU - Dontsova, O. A.

AU - Sergiev, P V

PY - 2020

DA - 2020/11/26

PB - Pleiades Publishing

SP - 1335-1349

IS - 11

VL - 85

PMID - 33280577

SN - 0006-2979

SN - 1608-3040

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2020_Osterman,

author = {I A Osterman and O. A. Dontsova and P V Sergiev},

title = {rRNA Methylation and Antibiotic Resistance},

journal = {Biochemistry (Moscow)},

year = {2020},

volume = {85},

publisher = {Pleiades Publishing},

month = {nov},

url = {http://link.springer.com/10.1134/S000629792011005X},

number = {11},

pages = {1335--1349},

doi = {10.1134/S000629792011005X}

}

MLA

Cite this

MLA Copy

Osterman, I. A., et al. “rRNA Methylation and Antibiotic Resistance.” Biochemistry (Moscow), vol. 85, no. 11, Nov. 2020, pp. 1335-1349. http://link.springer.com/10.1134/S000629792011005X.

Publisher

Pleiades Publishing

Journal

Biochemistry (Moscow)

scimago Q2

wos Q4

SJR

0.659

CiteScore

3.8

Impact factor

2.2

ISSN

00062979 (Print)

16083040 (Electronic)

Labs

Laboratory of Nucleoprotein Chemistry, Department of Chemistry of Natural Compounds, Faculty of Chemistry

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