Biochemistry (Moscow), volume 86, issue 10, pages 1163-1180
HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development
Publication type: Journal Article
Publication date: 2021-09-03
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
Oxygen deficiency is one of the key pathogenetic factors determining development and severity of many diseases, including inflammatory, infectious diseases, and cancer. Lack of oxygen activates the signaling pathway of the hypoxia-inducible transcription factor HIF in cells that has three isoforms, HIF-1, HIF-2, HIF-3, regulating expression of several thousand genes. Throughout tumor progression, HIF activation stimulates angiogenesis, promotes changes in cell metabolism, adhesion, invasiveness, and ability to metastasize. HIF isoforms can play opposite roles in the development of inflammatory and neoplastic processes. Humans and laboratory animals differ both in tolerance to hypoxia and in the levels of expression of HIF and HIF-dependent genes, which may lead to predisposition to the development of certain oncological disorders. In particular, the ratio of different histogenetic types of tumors may vary among people living in the mountains and at the sea level. However, despite the key role of hypoxia at almost all stages of tumor development, basal tolerance to oxygen deficiency is not considered as a factor of predisposition to the tumor growth initiation. In literature, there are many works characterizing the level of local hypoxia in various tumors, and suggesting fundamental approaches to its mitigation by HIF inhibition. HIF inhibitors, as a rule, have a systemic effect on the organism, however, basal tolerance of an organism to hypoxia as well as the level of HIF expression are not taken into account in the process of their use. The review summarizes the literature data on different HIF isoforms and their role in tumor progression, with extrapolation to organisms with high and low tolerance to hypoxia, as well as on the prevalence of various types of tumors in the populations living at high altitudes.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Dzhalilova D. S., Makarova O. V. HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development // Biochemistry (Moscow). 2021. Vol. 86. No. 10. pp. 1163-1180.
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Dzhalilova D. S., Makarova O. V. HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development // Biochemistry (Moscow). 2021. Vol. 86. No. 10. pp. 1163-1180.
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TY - JOUR
DO - 10.1134/S0006297921100011
UR - https://doi.org/10.1134%2FS0006297921100011
TI - HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development
T2 - Biochemistry (Moscow)
AU - Makarova, Olga V.
AU - Dzhalilova, Dzhuliia Sh
PY - 2021
DA - 2021/09/03 00:00:00
PB - Pleiades Publishing
SP - 1163-1180
IS - 10
VL - 86
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2021_Dzhalilova,
author = {Olga V. Makarova and Dzhuliia Sh Dzhalilova},
title = {HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development},
journal = {Biochemistry (Moscow)},
year = {2021},
volume = {86},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134%2FS0006297921100011},
number = {10},
pages = {1163--1180},
doi = {10.1134/S0006297921100011}
}
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Dzhalilova, Dzhuliia Sh, and Olga V. Makarova. “HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development.” Biochemistry (Moscow), vol. 86, no. 10, Sep. 2021, pp. 1163-1180. https://doi.org/10.1134%2FS0006297921100011.
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