Biochemistry. Biokhimiia, volume 86, issue 10, pages 1288-1300
Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease
Ovsiannikova Natalia L
1, 2
,
Lavrushkina Svetlana V
1, 2
,
Ivanova Anastasia V
3
,
Mazina Ludmila M
3
,
Kireev Igor I
1, 3, 4
1
Publication type: Journal Article
Publication date: 2021-10-20
Biochemistry
General Medicine
Abstract
One of the main factors associated with worse prognosis in oncology is metastasis, which is based on the ability of tumor cells to migrate from the primary source and to form secondary tumors. The search for new strategies to control migration of metastatic cells is one of the urgent issues in biomedicine. One of the strategies to stop spread of cancer cells could be regulation of the nuclear elasticity. Nucleus, as the biggest and stiffest cellular compartment, determines mechanical properties of the cell as a whole, and, hence, could prevent cell migration through the three-dimensional extracellular matrix. Nuclear rigidity is maintained by the nuclear lamina, two-dimensional network of intermediate filaments in the inner nuclear membrane (INM). Here we present the most significant factors defining nucleus rigidity, discuss the role of nuclear envelope composition in the cell migration, as well consider possible approaches to control lamina composition in order to change plasticity of the cell nucleus and ability of the tumor cells to metastasize.
Citations by journals
1
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Journal of Biological Engineering
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1 publication, 14.29%
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1 publication, 14.29%
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Citations by publishers
1
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Springer Nature
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2 publications, 28.57%
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1 publication, 14.29%
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1 publication, 14.29%
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Federation of American Societies for Experimental Biology (FASEB)
1 publication, 14.29%
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Elsevier
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1 publication, 14.29%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 14.29%
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1
2
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- We do not take into account publications that without a DOI.
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Ovsiannikova N. L. et al. Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease // Biochemistry. Biokhimiia. 2021. Vol. 86. No. 10. pp. 1288-1300.
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Ovsiannikova N. L., Lavrushkina S. V., Ivanova A. V., Mazina L. M., Zhironkina O. A., Kireev I. I. Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease // Biochemistry. Biokhimiia. 2021. Vol. 86. No. 10. pp. 1288-1300.
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TY - JOUR
DO - 10.1134/S0006297921100102
UR - https://doi.org/10.1134%2FS0006297921100102
TI - Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease
T2 - Biochemistry. Biokhimiia
AU - Mazina, Ludmila M
AU - Kireev, Igor I
AU - Ovsiannikova, Natalia L
AU - Ivanova, Anastasia V
AU - Zhironkina, Oxana A
AU - Lavrushkina, Svetlana V
PY - 2021
DA - 2021/10/20 00:00:00
PB - Akademizdatcenter Nauka
SP - 1288-1300
IS - 10
VL - 86
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2021_Ovsiannikova
author = {Ludmila M Mazina and Igor I Kireev and Natalia L Ovsiannikova and Anastasia V Ivanova and Oxana A Zhironkina and Svetlana V Lavrushkina},
title = {Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease},
journal = {Biochemistry. Biokhimiia},
year = {2021},
volume = {86},
publisher = {Akademizdatcenter Nauka},
month = {oct},
url = {https://doi.org/10.1134%2FS0006297921100102},
number = {10},
pages = {1288--1300},
doi = {10.1134/S0006297921100102}
}
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Ovsiannikova, Natalia L., et al. “Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease.” Biochemistry. Biokhimiia, vol. 86, no. 10, Oct. 2021, pp. 1288-1300. https://doi.org/10.1134%2FS0006297921100102.