Biochemistry. Biokhimiia, volume 86, issue 10, pages 1288-1300

Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease

Publication typeJournal Article
Publication date2021-10-20
Quartile SCImago
Quartile WOS
Impact factor
ISSN
Biochemistry
General Medicine
Abstract
One of the main factors associated with worse prognosis in oncology is metastasis, which is based on the ability of tumor cells to migrate from the primary source and to form secondary tumors. The search for new strategies to control migration of metastatic cells is one of the urgent issues in biomedicine. One of the strategies to stop spread of cancer cells could be regulation of the nuclear elasticity. Nucleus, as the biggest and stiffest cellular compartment, determines mechanical properties of the cell as a whole, and, hence, could prevent cell migration through the three-dimensional extracellular matrix. Nuclear rigidity is maintained by the nuclear lamina, two-dimensional network of intermediate filaments in the inner nuclear membrane (INM). Here we present the most significant factors defining nucleus rigidity, discuss the role of nuclear envelope composition in the cell migration, as well consider possible approaches to control lamina composition in order to change plasticity of the cell nucleus and ability of the tumor cells to metastasize.

Citations by journals

1
Journal of Biological Engineering
Journal of Biological Engineering, 1, 14.29%
Journal of Biological Engineering
1 publication, 14.29%
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, 1, 14.29%
Frontiers in Cell and Developmental Biology
1 publication, 14.29%
Biochemistry (Moscow)
Biochemistry (Moscow), 1, 14.29%
Biochemistry (Moscow)
1 publication, 14.29%
European Physical Journal: Special Topics
European Physical Journal: Special Topics, 1, 14.29%
European Physical Journal: Special Topics
1 publication, 14.29%
FASEB Journal
FASEB Journal, 1, 14.29%
FASEB Journal
1 publication, 14.29%
European Journal of Cell Biology
European Journal of Cell Biology, 1, 14.29%
European Journal of Cell Biology
1 publication, 14.29%
Cells
Cells, 1, 14.29%
Cells
1 publication, 14.29%
1

Citations by publishers

1
2
Springer Nature
Springer Nature, 2, 28.57%
Springer Nature
2 publications, 28.57%
Frontiers Media S.A.
Frontiers Media S.A., 1, 14.29%
Frontiers Media S.A.
1 publication, 14.29%
Pleiades Publishing
Pleiades Publishing, 1, 14.29%
Pleiades Publishing
1 publication, 14.29%
Federation of American Societies for Experimental Biology (FASEB)
Federation of American Societies for Experimental Biology (FASEB), 1, 14.29%
Federation of American Societies for Experimental Biology (FASEB)
1 publication, 14.29%
Elsevier
Elsevier, 1, 14.29%
Elsevier
1 publication, 14.29%
Multidisciplinary Digital Publishing Institute (MDPI)
Multidisciplinary Digital Publishing Institute (MDPI), 1, 14.29%
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 14.29%
1
2
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Ovsiannikova N. L. et al. Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease // Biochemistry. Biokhimiia. 2021. Vol. 86. No. 10. pp. 1288-1300.
GOST all authors (up to 50) Copy
Ovsiannikova N. L., Lavrushkina S. V., Ivanova A. V., Mazina L. M., Zhironkina O. A., Kireev I. I. Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease // Biochemistry. Biokhimiia. 2021. Vol. 86. No. 10. pp. 1288-1300.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/S0006297921100102
UR - https://doi.org/10.1134%2FS0006297921100102
TI - Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease
T2 - Biochemistry. Biokhimiia
AU - Mazina, Ludmila M
AU - Kireev, Igor I
AU - Ovsiannikova, Natalia L
AU - Ivanova, Anastasia V
AU - Zhironkina, Oxana A
AU - Lavrushkina, Svetlana V
PY - 2021
DA - 2021/10/20 00:00:00
PB - Akademizdatcenter Nauka
SP - 1288-1300
IS - 10
VL - 86
SN - 0006-2979
SN - 1608-3040
ER -
BibTex |
Cite this
BibTex Copy
@article{2021_Ovsiannikova
author = {Ludmila M Mazina and Igor I Kireev and Natalia L Ovsiannikova and Anastasia V Ivanova and Oxana A Zhironkina and Svetlana V Lavrushkina},
title = {Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease},
journal = {Biochemistry. Biokhimiia},
year = {2021},
volume = {86},
publisher = {Akademizdatcenter Nauka},
month = {oct},
url = {https://doi.org/10.1134%2FS0006297921100102},
number = {10},
pages = {1288--1300},
doi = {10.1134/S0006297921100102}
}
MLA
Cite this
MLA Copy
Ovsiannikova, Natalia L., et al. “Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease.” Biochemistry. Biokhimiia, vol. 86, no. 10, Oct. 2021, pp. 1288-1300. https://doi.org/10.1134%2FS0006297921100102.
Found error?