Molecular Biology, volume 40, issue 4, pages 514-527
Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase
Publication type: Journal Article
Publication date: 2006-07-01
Journal:
Molecular Biology
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1.2
ISSN: 00268933, 16083245
Structural Biology
Biophysics
Abstract
Telomerase is a ribonucleoprotein that extends telomeric ends of chromosomes to counterbalance their natural shortening due to incomplete DNA replication in eukaryotic cells. The core enzyme consists of the catalytic reverse transcriptase subunit TERT (Telomerase Reverse Transcriptase) and the RNA subunit TER (Telomerase RNA), a short specific region of which serves as a template for synthesis of telomeric repeats. Despite the intensive research of telomerase in different organisms, the mechanism of its action remains unclear. This review focuses on telomerase of yeast Saccharomyces cerevisiae. Unlike ciliate and human telomerases, the yeast enzyme adds only one telomeric repeat to the DNA oligonucleotide (primer), imitating the single-stranded telomeric end of a chromosome, and remains stably bound to it after elongation in vitro. This review summarizes the results of numerous studies on the structure and functions of the core enzyme components, their interactions with each other and a primer, and telomerase activity on different substrates in vitro. The peculiarities of telomerase functioning in a cell and accessory proteins of the telomerase complex are also discussed.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shcherbakova D. M. et al. Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase // Molecular Biology. 2006. Vol. 40. No. 4. pp. 514-527.
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Shcherbakova D. M., Zvereva M. E., Shpanchenko O. V., Dontsova O. A. Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase // Molecular Biology. 2006. Vol. 40. No. 4. pp. 514-527.
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TY - JOUR
DO - 10.1134/S0026893306040042
UR - https://doi.org/10.1134%2FS0026893306040042
TI - Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase
T2 - Molecular Biology
AU - Shcherbakova, D M
AU - Zvereva, M E
AU - Shpanchenko, O V
AU - Dontsova, O. A.
PY - 2006
DA - 2006/07/01 00:00:00
PB - Pleiades Publishing
SP - 514-527
IS - 4
VL - 40
SN - 0026-8933
SN - 1608-3245
ER -
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@article{2006_Shcherbakova,
author = {D M Shcherbakova and M E Zvereva and O V Shpanchenko and O. A. Dontsova},
title = {Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase},
journal = {Molecular Biology},
year = {2006},
volume = {40},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134%2FS0026893306040042},
number = {4},
pages = {514--527},
doi = {10.1134/S0026893306040042}
}
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MLA
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Shcherbakova, D. M., et al. “Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase.” Molecular Biology, vol. 40, no. 4, Jul. 2006, pp. 514-527. https://doi.org/10.1134%2FS0026893306040042.
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