Ruthenium(III) Complexes of NAMI-A Type with Ligands Based on Lonidamine and Bexarotene as Antiproliferative Agents
Тип публикации: Journal Article
Дата публикации: 2021-04-27
scimago Q3
wos Q4
БС2
SJR: 0.270
CiteScore: 3.0
Impact factor: 1.5
ISSN: 00360236, 15318613
Inorganic Chemistry
Physical and Theoretical Chemistry
Materials Science (miscellaneous)
Краткое описание
The search for new metal-containing antitumor agents is still carried out at present. Although platinum compounds are used in clinical practice, they show drawbacks such as high general toxicity and primary or acquired resistance. Ruthenium compounds showed the best potential among non-platinum antitumor agents, two of which—NAMI-A and KP1019 (КР1339)—are under clinical trials. In this work, we present the synthesis of full analogs of leader compound NAMI-A containing fragments of biologically active organic molecules, namely Lonidamine and Bexarotene. Electrochemical behavior of Ru(III) complexes has been studied and ease of reduction has been shown, which indicates the promise of their use as antitumor agents whose mechanism of action seems to be based on activation by metal atom reduction. The cytotoxicity of obtained complexes has been studied in vitro and IC50 values have been determined. Two compounds have been selected for further study.
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Shutkov I. A. et al. Ruthenium(III) Complexes of NAMI-A Type with Ligands Based on Lonidamine and Bexarotene as Antiproliferative Agents // Russian Journal of Inorganic Chemistry. 2021. Vol. 66. No. 4. pp. 502-509.
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Shutkov I. A., Antonets A. A., Tyurin V. Yu., Milaeva E. R., Nazarov A. A. Ruthenium(III) Complexes of NAMI-A Type with Ligands Based on Lonidamine and Bexarotene as Antiproliferative Agents // Russian Journal of Inorganic Chemistry. 2021. Vol. 66. No. 4. pp. 502-509.
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TY - JOUR
DO - 10.1134/S0036023621030177
UR - https://doi.org/10.1134/S0036023621030177
TI - Ruthenium(III) Complexes of NAMI-A Type with Ligands Based on Lonidamine and Bexarotene as Antiproliferative Agents
T2 - Russian Journal of Inorganic Chemistry
AU - Shutkov, I A
AU - Antonets, A A
AU - Tyurin, V Yu
AU - Milaeva, E R
AU - Nazarov, A A
PY - 2021
DA - 2021/04/27
PB - Pleiades Publishing
SP - 502-509
IS - 4
VL - 66
SN - 0036-0236
SN - 1531-8613
ER -
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@article{2021_Shutkov,
author = {I A Shutkov and A A Antonets and V Yu Tyurin and E R Milaeva and A A Nazarov},
title = {Ruthenium(III) Complexes of NAMI-A Type with Ligands Based on Lonidamine and Bexarotene as Antiproliferative Agents},
journal = {Russian Journal of Inorganic Chemistry},
year = {2021},
volume = {66},
publisher = {Pleiades Publishing},
month = {apr},
url = {https://doi.org/10.1134/S0036023621030177},
number = {4},
pages = {502--509},
doi = {10.1134/S0036023621030177}
}
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MLA
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Shutkov, I. A., et al. “Ruthenium(III) Complexes of NAMI-A Type with Ligands Based on Lonidamine and Bexarotene as Antiproliferative Agents.” Russian Journal of Inorganic Chemistry, vol. 66, no. 4, Apr. 2021, pp. 502-509. https://doi.org/10.1134/S0036023621030177.
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