Interaction of copolymers of dimethylsiloxane and ethylene oxide with model membranes and cancerous cells
Publication type: Journal Article
Publication date: 2009-03-01
scimago Q3
wos Q4
SJR: 0.244
CiteScore: 1.9
Impact factor: 1.1
ISSN: 0965545X, 15556107, 17571820
Materials Chemistry
Polymers and Plastics
Abstract
Interaction of amphiphilic copolymers and ethylene oxide and dimethylsiloxane with biological membranes is studied. Copolymers are shown to increase the permeability of model membranes. Has been shown that their effect on the permeability of liposomal membranes with respect to dye carboxyfluoresceine correlates with their toxicity. At low nontoxic concentrations, Pluronic L61, a diblock copolymer of dimeth-ylsiloxane and ethylene oxide similar to triblock copolymer of ethylene and propylene oxides, is able to reduce the concentration of chemotherapeutic drug doxorubicin by a factor of 30, which is toxic to cancerous cells stable to remedy drugs.
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Pavlov D. N. et al. Interaction of copolymers of dimethylsiloxane and ethylene oxide with model membranes and cancerous cells // Polymer Science - Series A. 2009. Vol. 51. No. 3. pp. 295-301.
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Pavlov D. N., Dorodnykh T. Yu., Zaborova O. V., Melik-Nubarov N. Interaction of copolymers of dimethylsiloxane and ethylene oxide with model membranes and cancerous cells // Polymer Science - Series A. 2009. Vol. 51. No. 3. pp. 295-301.
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RIS
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TY - JOUR
DO - 10.1134/S0965545X09030080
UR - http://link.springer.com/10.1134/S0965545X09030080
TI - Interaction of copolymers of dimethylsiloxane and ethylene oxide with model membranes and cancerous cells
T2 - Polymer Science - Series A
AU - Pavlov, D N
AU - Dorodnykh, T Yu
AU - Zaborova, O V
AU - Melik-Nubarov, N.S.
PY - 2009
DA - 2009/03/01
PB - Pleiades Publishing
SP - 295-301
IS - 3
VL - 51
SN - 0965-545X
SN - 1555-6107
SN - 1757-1820
ER -
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BibTex (up to 50 authors)
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@article{2009_Pavlov,
author = {D N Pavlov and T Yu Dorodnykh and O V Zaborova and N.S. Melik-Nubarov},
title = {Interaction of copolymers of dimethylsiloxane and ethylene oxide with model membranes and cancerous cells},
journal = {Polymer Science - Series A},
year = {2009},
volume = {51},
publisher = {Pleiades Publishing},
month = {mar},
url = {http://link.springer.com/10.1134/S0965545X09030080},
number = {3},
pages = {295--301},
doi = {10.1134/S0965545X09030080}
}
Cite this
MLA
Copy
Pavlov, D. N., et al. “Interaction of copolymers of dimethylsiloxane and ethylene oxide with model membranes and cancerous cells.” Polymer Science - Series A, vol. 51, no. 3, Mar. 2009, pp. 295-301. http://link.springer.com/10.1134/S0965545X09030080.
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