Polymer Science - Series A, volume 61, issue 3, pages 296-307
Magneto-Sensitive Multiliposomal Containers for Immobilization and Controlled Delivery of Bioactive Substances
Publication type: Journal Article
Publication date: 2019-05-31
Journal:
Polymer Science - Series A
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 1
ISSN: 0965545X, 15556107
Materials Chemistry
Polymers and Plastics
Abstract
Multiliposomal containers obtained by the successive adsorption of cationic polypeptide poly(L-lysine) and anionic liposomes on the surface of anionic magnetic microgels—the products of γ-Fe2O3 (maghemite) synthesis in the matrix of natural anionic polysaccharide—the mixed Na/Ca salt of alginic acid—are presented. The composition and morphology of magneto-sensitive microgels are studied by X-ray analysis, FTIR spectroscopy, Mössbauer spectroscopy, magnetometry, and transmission electron microscopy. The size of particles of multiliposomal containers with the ultimate liposome content in the physiological solution is about 400 nm. They are not cytotoxic up to a poly(L-lysine) concentration of 600 μM. It is shown that these objects filled with antitumor antibiotic—doxorubicin—are able to move in a suspension under application of an external magnetic field with the integrity of liposomes in the container being preserved. The obtained containers are promising for the controlled delivery of bioactive substances (drugs).
Citations by journals
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1
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Expert Opinion on Drug Delivery
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Expert Opinion on Drug Delivery
1 publication, 50%
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Polymer Science - Series C
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Polymer Science - Series C
1 publication, 50%
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1
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Citations by publishers
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1
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Taylor & Francis
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Taylor & Francis
1 publication, 50%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 50%
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1
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Spiridonov V. V. et al. Magneto-Sensitive Multiliposomal Containers for Immobilization and Controlled Delivery of Bioactive Substances // Polymer Science - Series A. 2019. Vol. 61. No. 3. pp. 296-307.
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Spiridonov V. V., Panova I. G., Sybachin A. V., Kuznetsov V. V., Afanasov M., Alekhina Yu. A., Melik-Nubarov N., Yaroslavov A. A. Magneto-Sensitive Multiliposomal Containers for Immobilization and Controlled Delivery of Bioactive Substances // Polymer Science - Series A. 2019. Vol. 61. No. 3. pp. 296-307.
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TY - JOUR
DO - 10.1134/S0965545X19030167
UR - https://doi.org/10.1134%2FS0965545X19030167
TI - Magneto-Sensitive Multiliposomal Containers for Immobilization and Controlled Delivery of Bioactive Substances
T2 - Polymer Science - Series A
AU - Spiridonov, V V
AU - Panova, I. G.
AU - Kuznetsov, V. V.
AU - Melik-Nubarov, N.S.
AU - Yaroslavov, A A
AU - Sybachin, A V
AU - Afanasov, M.I
AU - Alekhina, Yu A
PY - 2019
DA - 2019/05/31 00:00:00
PB - Pleiades Publishing
SP - 296-307
IS - 3
VL - 61
SN - 0965-545X
SN - 1555-6107
ER -
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@article{2019_Spiridonov,
author = {V V Spiridonov and I. G. Panova and V. V. Kuznetsov and N.S. Melik-Nubarov and A A Yaroslavov and A V Sybachin and M.I Afanasov and Yu A Alekhina},
title = {Magneto-Sensitive Multiliposomal Containers for Immobilization and Controlled Delivery of Bioactive Substances},
journal = {Polymer Science - Series A},
year = {2019},
volume = {61},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.1134%2FS0965545X19030167},
number = {3},
pages = {296--307},
doi = {10.1134/S0965545X19030167}
}
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MLA
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Spiridonov, V. V., et al. “Magneto-Sensitive Multiliposomal Containers for Immobilization and Controlled Delivery of Bioactive Substances.” Polymer Science - Series A, vol. 61, no. 3, May. 2019, pp. 296-307. https://doi.org/10.1134%2FS0965545X19030167.
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