volume 38 issue 5 pages 550-557

Neuroprotective activity of (+)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8- tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid

Publication typeJournal Article
Publication date2012-09-13
scimago Q4
wos Q3
SJR0.267
CiteScore1.9
Impact factor1.7
ISSN10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
A study of the neurotropic, neuroprotective, and antioxidant action of the enantiomers and racemate of 2-[(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid synthesized in a stereoselective reaction of (R)-, (S)-, or (R,S)-N-carbamoylmethionine with 4,5-dihydroxyimidazolidine-2-one showed that only (+)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid had neuroprotective properties. X-ray structure analysis showed that the predominating racemate of glycolurils is crystallized from aqueous solutions as a conglomerate. Antioxidant activity was not detected.
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GOST Copy
Kravchenko A. N. et al. Neuroprotective activity of (+)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8- tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid // Russian Journal of Bioorganic Chemistry. 2012. Vol. 38. No. 5. pp. 550-557.
GOST all authors (up to 50) Copy
Kravchenko A. N., Baranov V., Anikina L. V., Vikharev Yu. B., Bushmarinov I. S., Nelyubina Yu. V. Neuroprotective activity of (+)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8- tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid // Russian Journal of Bioorganic Chemistry. 2012. Vol. 38. No. 5. pp. 550-557.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/S106816201205007X
UR - http://link.springer.com/10.1134/S106816201205007X
TI - Neuroprotective activity of (+)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8- tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid
T2 - Russian Journal of Bioorganic Chemistry
AU - Kravchenko, A N
AU - Baranov, V.V.
AU - Anikina, L V
AU - Vikharev, Yu B
AU - Bushmarinov, I S
AU - Nelyubina, Yu V
PY - 2012
DA - 2012/09/13
PB - Pleiades Publishing
SP - 550-557
IS - 5
VL - 38
PMID - 23342496
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2012_Kravchenko,
author = {A N Kravchenko and V.V. Baranov and L V Anikina and Yu B Vikharev and I S Bushmarinov and Yu V Nelyubina},
title = {Neuroprotective activity of (+)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8- tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2012},
volume = {38},
publisher = {Pleiades Publishing},
month = {sep},
url = {http://link.springer.com/10.1134/S106816201205007X},
number = {5},
pages = {550--557},
doi = {10.1134/S106816201205007X}
}
MLA
Cite this
MLA Copy
Kravchenko, A. N., et al. “Neuroprotective activity of (+)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8- tetraazabicyclo[3.3.0]oct-2-yl)]-4-methylthiobutanoic acid.” Russian Journal of Bioorganic Chemistry, vol. 38, no. 5, Sep. 2012, pp. 550-557. http://link.springer.com/10.1134/S106816201205007X.