Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid
Тип публикации: Journal Article
Дата публикации: 2013-03-21
SCImago Q4
WOS Q3
БС2
SJR: 0.255
CiteScore: 2.5
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
PubMed ID:
23964524
Organic Chemistry
Biochemistry
Краткое описание
The synthesis of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid was carried out and its structure was established by X-ray diffraction. The antineoplastic activity and the ability to induce apoptosis that were predicted by a PASS computer system, correlate well with the experimentally found cytotoxic activity towards the MeWo malignant cell line. The results of tests on animals showed that abietic acid and its (7R,8S)-epoxy-(13R,17R)-trioxolane derivative have anti-inflammatory and antiulcer activities in the absence of side effects.
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Kazakova O. B. et al. Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid // Russian Journal of Bioorganic Chemistry. 2013. Vol. 39. No. 2. pp. 202-210.
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Kazakova O. B., Smirnova I., Tkhu H. D. T., Nguen T. T., Apryshko G. N., Zhukova O. S., Medvedeva N. I., Nazyrov T. I., Tretyakova E. V., Chudov I. V., Ismagilova A. F., Suponitsky K. Yu., Kazakov D., Safarov F. E., Tolstikov G. Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid // Russian Journal of Bioorganic Chemistry. 2013. Vol. 39. No. 2. pp. 202-210.
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TY - JOUR
DO - 10.1134/S1068162013020088
UR - https://doi.org/10.1134/S1068162013020088
TI - Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid
T2 - Russian Journal of Bioorganic Chemistry
AU - Kazakova, O B
AU - Smirnova, I.E
AU - Tkhu, H Do Tkhi
AU - Nguen, Tkhankh Tra
AU - Apryshko, G N
AU - Zhukova, O S
AU - Medvedeva, N. I.
AU - Nazyrov, T I
AU - Tretyakova, E V
AU - Chudov, I V
AU - Ismagilova, A F
AU - Suponitsky, K Yu
AU - Kazakov, D.V.
AU - Safarov, F E
AU - Tolstikov, G.A.
PY - 2013
DA - 2013/03/21
PB - Pleiades Publishing
SP - 202-210
IS - 2
VL - 39
PMID - 23964524
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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@article{2013_Kazakova,
author = {O B Kazakova and I.E Smirnova and H Do Tkhi Tkhu and Tkhankh Tra Nguen and G N Apryshko and O S Zhukova and N. I. Medvedeva and T I Nazyrov and E V Tretyakova and I V Chudov and A F Ismagilova and K Yu Suponitsky and D.V. Kazakov and F E Safarov and G.A. Tolstikov},
title = {Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2013},
volume = {39},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/S1068162013020088},
number = {2},
pages = {202--210},
doi = {10.1134/S1068162013020088}
}
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Kazakova, O. B., et al. “Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid.” Russian Journal of Bioorganic Chemistry, vol. 39, no. 2, Mar. 2013, pp. 202-210. https://doi.org/10.1134/S1068162013020088.
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