Investigation of the complex antibiotic INA-5812
O A Lapchinskaya
1
,
G S Katrukha
1
,
E G Gladkikh
1
,
V V Kulyaeva
1
,
P V Coodan
2
,
A P Topolyan
3
,
V A Alferova
1
,
V V Pogozheva
1
,
M A Sukonnikov
4
,
E. A. Rogozhin
1, 3
,
I A Prokhorenko
1, 3
,
V. A. Brylev
3
,
A.M Korolev
1
,
M S Slyundina
1, 5
,
R S Borisov
5, 6
,
M V Serebryakova
7
,
M V Shuvalov
1, 4
,
A. L. Ksenofontov
7
,
L G Stoyanova
8
,
I A Osterman
4, 7
,
A.A Formanovsky
3
,
V N Tashlitsky
4
,
L A Baratova
7
,
A. V. Timofeeva
7
,
A P Tyurin
1, 3
Publication type: Journal Article
Publication date: 2016-11-01
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
A concentrate with the antimicrobial activity has been isolated from the culture broth of Streptomyces roseoflavus INA-Ac-5812. Its further fractionation by reversed-phase HPLC has resulted in six fractions. It has been established by MALDI-TOF and ESI-MSn precision mass-spectrometry methods that the main components of the complex antibiotic are several closely related compounds, presumably of a glycopeptide nature. The fraction containing an individual component with a mass of 1845.788 Da has been characterized by UV/Vis absorbance and fluorescence spectra, amino acid analysis, and derivatization with tris(2,6-dimethoxyphenyl)methyl cation. The activity of fractions against pathogenic microbes has been studied. The results allow the supposition that the INA-5812 antibiotic complex is a glyco- or lipoglycopeptide antibiotic of a new type, which is very promising for further study.
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Total citations:
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GOST
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Lapchinskaya O. A. et al. Investigation of the complex antibiotic INA-5812 // Russian Journal of Bioorganic Chemistry. 2016. Vol. 42. No. 6. pp. 664-671.
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Lapchinskaya O. A., Katrukha G. S., Gladkikh E. G., Kulyaeva V. V., Coodan P. V., Topolyan A. P., Alferova V. A., Pogozheva V. V., Sukonnikov M. A., Rogozhin E. A., Prokhorenko I. A., Brylev V. A., Korolev A., Slyundina M. S., Borisov R. S., Serebryakova M. V., Shuvalov M. V., Ksenofontov A. L., Stoyanova L. G., Osterman I. A., Formanovsky A., Tashlitsky V. N., Baratova L. A., Timofeeva A. V., Tyurin A. P. Investigation of the complex antibiotic INA-5812 // Russian Journal of Bioorganic Chemistry. 2016. Vol. 42. No. 6. pp. 664-671.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S1068162016060078
UR - https://doi.org/10.1134/S1068162016060078
TI - Investigation of the complex antibiotic INA-5812
T2 - Russian Journal of Bioorganic Chemistry
AU - Lapchinskaya, O A
AU - Katrukha, G S
AU - Gladkikh, E G
AU - Kulyaeva, V V
AU - Coodan, P V
AU - Topolyan, A P
AU - Alferova, V A
AU - Pogozheva, V V
AU - Sukonnikov, M A
AU - Rogozhin, E. A.
AU - Prokhorenko, I A
AU - Brylev, V. A.
AU - Korolev, A.M
AU - Slyundina, M S
AU - Borisov, R S
AU - Serebryakova, M V
AU - Shuvalov, M V
AU - Ksenofontov, A. L.
AU - Stoyanova, L G
AU - Osterman, I A
AU - Formanovsky, A.A
AU - Tashlitsky, V N
AU - Baratova, L A
AU - Timofeeva, A. V.
AU - Tyurin, A P
PY - 2016
DA - 2016/11/01
PB - Pleiades Publishing
SP - 664-671
IS - 6
VL - 42
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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BibTex (up to 50 authors)
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@article{2016_Lapchinskaya,
author = {O A Lapchinskaya and G S Katrukha and E G Gladkikh and V V Kulyaeva and P V Coodan and A P Topolyan and V A Alferova and V V Pogozheva and M A Sukonnikov and E. A. Rogozhin and I A Prokhorenko and V. A. Brylev and A.M Korolev and M S Slyundina and R S Borisov and M V Serebryakova and M V Shuvalov and A. L. Ksenofontov and L G Stoyanova and I A Osterman and A.A Formanovsky and V N Tashlitsky and L A Baratova and A. V. Timofeeva and A P Tyurin},
title = {Investigation of the complex antibiotic INA-5812},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2016},
volume = {42},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://doi.org/10.1134/S1068162016060078},
number = {6},
pages = {664--671},
doi = {10.1134/S1068162016060078}
}
Cite this
MLA
Copy
Lapchinskaya, O. A., et al. “Investigation of the complex antibiotic INA-5812.” Russian Journal of Bioorganic Chemistry, vol. 42, no. 6, Nov. 2016, pp. 664-671. https://doi.org/10.1134/S1068162016060078.