Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments
A D Voloshina
1
,
V E Semenov
1
,
A S Strobykina
1
,
N V Kulik
1
,
E S Krylova
1
,
V.V. Zobov
1
,
V.S. Reznik
1
Publication type: Journal Article
Publication date: 2017-03-01
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
The antimicrobial activity and cytotoxicity of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments in alkyl chains have been studied. The compounds have been tested for the antimicrobial activity toward some gram-positive and gram-negative bacteria and fungal cultures. The cytotoxic action has been estimated toward mammalian cells. It has been found that the basic structural factor that affects the antimicrobial activity is the nature of alkyl radicals at triazole fragments.
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Total citations:
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Citations from 2024:
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(15.87%)
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Voloshina A. D. et al. Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 2. pp. 170-176.
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Voloshina A. D., Semenov V. E., Strobykina A. S., Kulik N. V., Krylova E. S., Zobov V., Reznik V. Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 2. pp. 170-176.
Cite this
RIS
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TY - JOUR
DO - 10.1134/S1068162017020170
UR - https://doi.org/10.1134/S1068162017020170
TI - Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments
T2 - Russian Journal of Bioorganic Chemistry
AU - Voloshina, A D
AU - Semenov, V E
AU - Strobykina, A S
AU - Kulik, N V
AU - Krylova, E S
AU - Zobov, V.V.
AU - Reznik, V.S.
PY - 2017
DA - 2017/03/01
PB - Pleiades Publishing
SP - 170-176
IS - 2
VL - 43
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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@article{2017_Voloshina,
author = {A D Voloshina and V E Semenov and A S Strobykina and N V Kulik and E S Krylova and V.V. Zobov and V.S. Reznik},
title = {Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2017},
volume = {43},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/S1068162017020170},
number = {2},
pages = {170--176},
doi = {10.1134/S1068162017020170}
}
Cite this
MLA
Copy
Voloshina, A. D., et al. “Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments.” Russian Journal of Bioorganic Chemistry, vol. 43, no. 2, Mar. 2017, pp. 170-176. https://doi.org/10.1134/S1068162017020170.