Russian Journal of Bioorganic Chemistry, volume 43, issue 3, pages 278-285

The docetaxel polymeric form and its antitumor activity

Zhunina O A 1
Yabbarov N G 1
Tereshchenko O G 1
Godovannyy A V 1
Gukasova N V 1
Severin E S. 1
1
 
JSC Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russia
Publication typeJournal Article
Publication date2017-05-01
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor1
ISSN10681620, 1608330X
Organic Chemistry
Biochemistry
Abstract
A new pharmaceutical form of the antitumor drug docetaxel (Dtx) has been developed based on a biodegradable copolymer of lactic and glycolic acids (PLGA 50/50). This form was constituted of polymeric particles (250 to 300 nm in size) and was highly active against mouse mammary adenocarcinoma (Ca755) and human breast adenocarcinoma (MCF-7Wt) cell lines. The results of the in vivo studies carried out on the C57Bl/6 female mice line showed an increase in the life span of the animals treated with the polymeric particles. Furthermore, the polymeric drug at a dose of 10 mg/kg and the drug substance at a dose of 20 mg/kg manifested a similar effect. At the same time, the acute toxicity of the Dtx polymeric form was 2.3 times lower than that of the drug substance.

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GOST Copy
Nikolskaya E. D. et al. The docetaxel polymeric form and its antitumor activity // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 3. pp. 278-285.
GOST all authors (up to 50) Copy
Nikolskaya E. D., Zhunina O. A., Yabbarov N. G., Tereshchenko O. G., Godovannyy A. V., Gukasova N. V., Severin E. S. The docetaxel polymeric form and its antitumor activity // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 3. pp. 278-285.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/S1068162017030116
UR - https://doi.org/10.1134%2FS1068162017030116
TI - The docetaxel polymeric form and its antitumor activity
T2 - Russian Journal of Bioorganic Chemistry
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Yabbarov, N G
AU - Tereshchenko, O G
AU - Godovannyy, A V
AU - Gukasova, N V
AU - Severin, E S.
PY - 2017
DA - 2017/05/01 00:00:00
PB - Pleiades Publishing
SP - 278-285
IS - 3
VL - 43
SN - 1068-1620
SN - 1608-330X
ER -
BibTex |
Cite this
BibTex Copy
@article{2017_Nikolskaya
author = {E D Nikolskaya and O A Zhunina and N G Yabbarov and O G Tereshchenko and A V Godovannyy and N V Gukasova and E S. Severin},
title = {The docetaxel polymeric form and its antitumor activity},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2017},
volume = {43},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.1134%2FS1068162017030116},
number = {3},
pages = {278--285},
doi = {10.1134/S1068162017030116}
}
MLA
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MLA Copy
Nikolskaya, E. D., et al. “The docetaxel polymeric form and its antitumor activity.” Russian Journal of Bioorganic Chemistry, vol. 43, no. 3, May. 2017, pp. 278-285. https://doi.org/10.1134%2FS1068162017030116.
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