The docetaxel polymeric form and its antitumor activity

Nikolskaya E.D., Zhunina O.A., Yabbarov N.G., Tereshchenko O.G., Godovannyy A.V., Gukasova N.V., Severin E.S.
Тип документаJournal Article
Дата публикации2017-05-01
Название журналаRussian Journal of Bioorganic Chemistry
ИздательPleiades Publishing
Квартиль по SCImagoQ4
Квартиль по Web of ScienceQ4
Импакт-фактор 20211.25
ISSN10681620, 1608330X
Organic Chemistry
Biochemistry
Краткое описание
A new pharmaceutical form of the antitumor drug docetaxel (Dtx) has been developed based on a biodegradable copolymer of lactic and glycolic acids (PLGA 50/50). This form was constituted of polymeric particles (250 to 300 nm in size) and was highly active against mouse mammary adenocarcinoma (Ca755) and human breast adenocarcinoma (MCF-7Wt) cell lines. The results of the in vivo studies carried out on the C57Bl/6 female mice line showed an increase in the life span of the animals treated with the polymeric particles. Furthermore, the polymeric drug at a dose of 10 mg/kg and the drug substance at a dose of 20 mg/kg manifested a similar effect. At the same time, the acute toxicity of the Dtx polymeric form was 2.3 times lower than that of the drug substance.
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1. Nikolskaya E.D. и др. The docetaxel polymeric form and its antitumor activity // Russian Journal of Bioorganic Chemistry. 2017. Т. 43. № 3. С. 278–285.
RIS |
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TY - JOUR

DO - 10.1134/s1068162017030116

UR - http://dx.doi.org/10.1134/S1068162017030116

TI - The docetaxel polymeric form and its antitumor activity

T2 - Russian Journal of Bioorganic Chemistry

AU - Nikolskaya, E. D.

AU - Zhunina, O. A.

AU - Yabbarov, N. G.

AU - Tereshchenko, O. G.

AU - Godovannyy, A. V.

AU - Gukasova, N. V.

AU - Severin, E. S.

PY - 2017

DA - 2017/05

PB - Pleiades Publishing Ltd

SP - 278-285

IS - 3

VL - 43

SN - 1068-1620

SN - 1608-330X

ER -

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@article{Nikolskaya_2017,

doi = {10.1134/s1068162017030116},

url = {https://doi.org/10.1134%2Fs1068162017030116},

year = 2017,

month = {may},

publisher = {Pleiades Publishing Ltd},

volume = {43},

number = {3},

pages = {278--285},

author = {E. D. Nikolskaya and O. A. Zhunina and N. G. Yabbarov and O. G. Tereshchenko and A. V. Godovannyy and N. V. Gukasova and E. S. Severin},

title = {The docetaxel polymeric form and its antitumor activity},

journal = {Russian Journal of Bioorganic Chemistry}

}

MLA
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Nikolskaya, E. D. et al. “The Docetaxel Polymeric Form and Its Antitumor Activity.” Russian Journal of Bioorganic Chemistry 43.3 (2017): 278–285. Crossref. Web.