The docetaxel polymeric form and its antitumor activity
E D Nikolskaya
1
,
O A Zhunina
1
,
N G Yabbarov
1
,
O G Tereshchenko
1
,
A V Godovannyy
1
,
N V Gukasova
1
,
E S. Severin
1
1
JSC Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2017-05-01
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
A new pharmaceutical form of the antitumor drug docetaxel (Dtx) has been developed based on a biodegradable copolymer of lactic and glycolic acids (PLGA 50/50). This form was constituted of polymeric particles (250 to 300 nm in size) and was highly active against mouse mammary adenocarcinoma (Ca755) and human breast adenocarcinoma (MCF-7Wt) cell lines. The results of the in vivo studies carried out on the C57Bl/6 female mice line showed an increase in the life span of the animals treated with the polymeric particles. Furthermore, the polymeric drug at a dose of 10 mg/kg and the drug substance at a dose of 20 mg/kg manifested a similar effect. At the same time, the acute toxicity of the Dtx polymeric form was 2.3 times lower than that of the drug substance.
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7
Total citations:
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Citations from 2024:
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(28%)
The most citing journal
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MLA
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GOST
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Nikolskaya E. D. et al. The docetaxel polymeric form and its antitumor activity // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 3. pp. 278-285.
GOST all authors (up to 50)
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Nikolskaya E. D., Zhunina O. A., Yabbarov N. G., Tereshchenko O. G., Godovannyy A. V., Gukasova N. V., Severin E. S. The docetaxel polymeric form and its antitumor activity // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 3. pp. 278-285.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S1068162017030116
UR - https://doi.org/10.1134/S1068162017030116
TI - The docetaxel polymeric form and its antitumor activity
T2 - Russian Journal of Bioorganic Chemistry
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Yabbarov, N G
AU - Tereshchenko, O G
AU - Godovannyy, A V
AU - Gukasova, N V
AU - Severin, E S.
PY - 2017
DA - 2017/05/01
PB - Pleiades Publishing
SP - 278-285
IS - 3
VL - 43
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Nikolskaya,
author = {E D Nikolskaya and O A Zhunina and N G Yabbarov and O G Tereshchenko and A V Godovannyy and N V Gukasova and E S. Severin},
title = {The docetaxel polymeric form and its antitumor activity},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2017},
volume = {43},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.1134/S1068162017030116},
number = {3},
pages = {278--285},
doi = {10.1134/S1068162017030116}
}
Cite this
MLA
Copy
Nikolskaya, E. D., et al. “The docetaxel polymeric form and its antitumor activity.” Russian Journal of Bioorganic Chemistry, vol. 43, no. 3, May. 2017, pp. 278-285. https://doi.org/10.1134/S1068162017030116.