Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals
G S Tsebrikova
1
,
V E Baulin
1, 2
,
I P Kalashnikova
1, 2
,
V V Ragulin
2
,
V O Zavelskii
2
,
A Ya Maruk
3
,
A S Lunev
3
,
O E Klementeva
3
,
G. E. Kodina
3
,
2
Publication type: Journal Article
Publication date: 2015-09-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
The known methods of preparation of cyclen-containing phosphonic acids, promising components of radiopharmaceuticals, have been improved, and new approaches have been developed. Application of 31Р and 13С NMR spectroscopy for initial screening of complex formation between cyclen-containing phosphonic acids and Ga3+ in D2O has been demonstrated. The conditions of 68Ga complex formation with cyclencontaining phosphonic acids and estimation of their radiochemical yield in water by means of thin-layer chromatography have been elaborated. A correlation between the NMR and TLC data has been found. Biological distribution of the selected 68Ga radiopharmaceuticals has been determined in vivo from the positron emission tomography data. The obtained standardized uptake values point at the osteotropicity of the 68Ga compounds.
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Tsebrikova G. S. et al. Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals // Russian Journal of General Chemistry. 2015. Vol. 85. No. 9. pp. 2071-2079.
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Tsebrikova G. S., Baulin V. E., Kalashnikova I. P., Ragulin V. V., Zavelskii V. O., Maruk A. Ya., Lunev A. S., Klementeva O. E., Kodina G. E., Tsivadze A. Y. Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals // Russian Journal of General Chemistry. 2015. Vol. 85. No. 9. pp. 2071-2079.
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RIS
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TY - JOUR
DO - 10.1134/S1070363215090091
UR - http://link.springer.com/10.1134/S1070363215090091
TI - Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals
T2 - Russian Journal of General Chemistry
AU - Tsebrikova, G S
AU - Baulin, V E
AU - Kalashnikova, I P
AU - Ragulin, V V
AU - Zavelskii, V O
AU - Maruk, A Ya
AU - Lunev, A S
AU - Klementeva, O E
AU - Kodina, G. E.
AU - Tsivadze, A. Yu.
PY - 2015
DA - 2015/09/01
PB - Pleiades Publishing
SP - 2071-2079
IS - 9
VL - 85
SN - 1070-3632
SN - 1608-3350
ER -
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BibTex (up to 50 authors)
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@article{2015_Tsebrikova,
author = {G S Tsebrikova and V E Baulin and I P Kalashnikova and V V Ragulin and V O Zavelskii and A Ya Maruk and A S Lunev and O E Klementeva and G. E. Kodina and A. Yu. Tsivadze},
title = {Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals},
journal = {Russian Journal of General Chemistry},
year = {2015},
volume = {85},
publisher = {Pleiades Publishing},
month = {sep},
url = {http://link.springer.com/10.1134/S1070363215090091},
number = {9},
pages = {2071--2079},
doi = {10.1134/S1070363215090091}
}
Cite this
MLA
Copy
Tsebrikova, G. S., et al. “Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals.” Russian Journal of General Chemistry, vol. 85, no. 9, Sep. 2015, pp. 2071-2079. http://link.springer.com/10.1134/S1070363215090091.