Russian Journal of General Chemistry

, том 85 , издание 9 , страницы 2071-2079

Cyclen-containing phosphonic acids as components of osteotropic ⁶⁸Ga radiopharmaceuticals

G S Tsebrikova ¹

V E Baulin ^{1, 2}

I P Kalashnikova ^{1, 2}

V V Ragulin ²

V O Zavelskii ²

A Ya Maruk ³

A S Lunev ³

O E Klementeva ³

G. E. Kodina ³

A. Yu. Tsivadze ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 3 аффилиации

Frumkin Institute of Physical Chemistry and electrochemistry, Russian Academy of Sciences, Moscow, Russia |

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia |

Burnazyan Federal Medical Biophysical Center, Federal Medical Biological Agency of Russia, Moscow, Russia |

Тип публикации: Journal Article

Дата публикации: 2015-09-01

Pleiades Publishing

Russian Journal of General Chemistry

scimago Q4

wos Q4

БС2

SJR: 0.179

CiteScore: 1.4

Impact factor: 0.8

ISSN: 10703632, 16083350

DOI: 10.1134/S1070363215090091

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General Chemistry

Краткое описание

The known methods of preparation of cyclen-containing phosphonic acids, promising components of radiopharmaceuticals, have been improved, and new approaches have been developed. Application of 31Р and 13С NMR spectroscopy for initial screening of complex formation between cyclen-containing phosphonic acids and Ga3+ in D2O has been demonstrated. The conditions of 68Ga complex formation with cyclencontaining phosphonic acids and estimation of their radiochemical yield in water by means of thin-layer chromatography have been elaborated. A correlation between the NMR and TLC data has been found. Biological distribution of the selected 68Ga radiopharmaceuticals has been determined in vivo from the positron emission tomography data. The obtained standardized uptake values point at the osteotropicity of the 68Ga compounds.

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Russian Journal of General Chemistry	Russian Journal of General Chemistry, 3, 30% Russian Journal of General Chemistry 3 публикации, 30%
Russian Chemical Bulletin	Russian Chemical Bulletin, 1, 10% Russian Chemical Bulletin 1 публикация, 10%
Molecular Diversity	Molecular Diversity, 1, 10% Molecular Diversity 1 публикация, 10%
Polyhedron	Polyhedron, 1, 10% Polyhedron 1 публикация, 10%
Biomedical Chemistry Research and Methods	Biomedical Chemistry Research and Methods, 1, 10% Biomedical Chemistry Research and Methods 1 публикация, 10%
Inorganica Chimica Acta	Inorganica Chimica Acta, 1, 10% Inorganica Chimica Acta 1 публикация, 10%
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Tsebrikova G. S. et al. Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals // Russian Journal of General Chemistry. 2015. Vol. 85. No. 9. pp. 2071-2079.

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Tsebrikova G. S., Baulin V. E., Kalashnikova I. P., Ragulin V. V., Zavelskii V. O., Maruk A. Ya., Lunev A. S., Klementeva O. E., Kodina G. E., Tsivadze A. Y. Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals // Russian Journal of General Chemistry. 2015. Vol. 85. No. 9. pp. 2071-2079.

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TY - JOUR

DO - 10.1134/S1070363215090091

UR - http://link.springer.com/10.1134/S1070363215090091

TI - Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals

T2 - Russian Journal of General Chemistry

AU - Tsebrikova, G S

AU - Baulin, V E

AU - Kalashnikova, I P

AU - Ragulin, V V

AU - Zavelskii, V O

AU - Maruk, A Ya

AU - Lunev, A S

AU - Klementeva, O E

AU - Kodina, G. E.

AU - Tsivadze, A. Yu.

PY - 2015

DA - 2015/09/01

PB - Pleiades Publishing

SP - 2071-2079

IS - 9

VL - 85

SN - 1070-3632

SN - 1608-3350

ER -

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@article{2015_Tsebrikova,

author = {G S Tsebrikova and V E Baulin and I P Kalashnikova and V V Ragulin and V O Zavelskii and A Ya Maruk and A S Lunev and O E Klementeva and G. E. Kodina and A. Yu. Tsivadze},

title = {Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals},

journal = {Russian Journal of General Chemistry},

year = {2015},

volume = {85},

publisher = {Pleiades Publishing},

month = {sep},

url = {http://link.springer.com/10.1134/S1070363215090091},

number = {9},

pages = {2071--2079},

doi = {10.1134/S1070363215090091}

}

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Tsebrikova, G. S., et al. “Cyclen-containing phosphonic acids as components of osteotropic 68Ga radiopharmaceuticals.” Russian Journal of General Chemistry, vol. 85, no. 9, Sep. 2015, pp. 2071-2079. http://link.springer.com/10.1134/S1070363215090091.