Russian Journal of General Chemistry

, volume 88 , issue 9 , pages 1786-1791

Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity

V E Baulin ^{1, 2}

I P Kalashnikova ¹

Yu B Vikharev ¹

E A Vikhareva ¹

D V Baulin ²

A. Yu. Tsivadze ²

Hide authors affiliations Show authors affiliations: 2 affiliations

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia |

Frumkin Institute of Physical Chemistry and Electrochemistry, Moscow, Russia |

Publication type: Journal Article

Publication date: 2018-09-01

Pleiades Publishing

Russian Journal of General Chemistry

scimago Q4

wos Q4

SJR: 0.179

CiteScore: 1.4

Impact factor: 0.8

ISSN: 10703632, 16083350

DOI: 10.1134/S1070363218090049

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General Chemistry

Abstract

The synthetically convenient method of preparation of unexplored phosphoryl analogs of salicylic acid (2-hydroxyphenylphosphonic and 2-hydroxyphenylphosphinic acids) has been developed for the search of novel nonsteroidal anti-inflammatory drugs. It has been shown that 2-hydroxyphenylphosphinic acid is a lowtoxic compound (LD50 3500 mg/kg) exhibiting analgesic activity significantly higher than both 2-hydroxyphenylphosphonic acid and the reference compound (sodium metamizole).

Found

4 citations

Solov’Ev Vitaly

DSc in Chemistry, associate professor

81 publications, 1 923 citations, 1 review

h-index: 24

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

Research interests

Chemoinformatics

Physical Chemistry

2 citations

Bezdomnikov Aleksey

🥼 🤝

PhD in Chemistry

15 publications, 277 citations, 7 reviews

h-index: 7

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

Research interests

Inorganic Chemistry

Physical Chemistry

1 citation

Tarakanova Elena

71 publications, 490 citations

h-index: 12

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

1 citation

Sharov Vladislav

11 publications, 39 citations

h-index: 5

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

Research interests

Chemistry

Liquid extraction (Liquid-Liquid extraction)

Radiochemistry

Rare Earth elements

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Baulin V. E. et al. Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity // Russian Journal of General Chemistry. 2018. Vol. 88. No. 9. pp. 1786-1791.

GOST all authors (up to 50) Copy

Baulin V. E., Kalashnikova I. P., Vikharev Yu. B., Vikhareva E. A., Baulin D. V., Tsivadze A. Y. Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity // Russian Journal of General Chemistry. 2018. Vol. 88. No. 9. pp. 1786-1791.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1134/S1070363218090049

UR - http://link.springer.com/10.1134/S1070363218090049

TI - Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity

T2 - Russian Journal of General Chemistry

AU - Baulin, V E

AU - Kalashnikova, I P

AU - Vikharev, Yu B

AU - Vikhareva, E A

AU - Baulin, D V

AU - Tsivadze, A. Yu.

PY - 2018

DA - 2018/09/01

PB - Pleiades Publishing

SP - 1786-1791

IS - 9

VL - 88

SN - 1070-3632

SN - 1608-3350

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Baulin,

author = {V E Baulin and I P Kalashnikova and Yu B Vikharev and E A Vikhareva and D V Baulin and A. Yu. Tsivadze},

title = {Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity},

journal = {Russian Journal of General Chemistry},

year = {2018},

volume = {88},

publisher = {Pleiades Publishing},

month = {sep},

url = {http://link.springer.com/10.1134/S1070363218090049},

number = {9},

pages = {1786--1791},

doi = {10.1134/S1070363218090049}

}

MLA

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MLA Copy

Baulin, V. E., et al. “Phosphoryl Analogs of Salicylic Acid: Synthesis and Analgesic and Anti-Inflammatory Activity.” Russian Journal of General Chemistry, vol. 88, no. 9, Sep. 2018, pp. 1786-1791. http://link.springer.com/10.1134/S1070363218090049.