Russian Journal of General Chemistry

, том 89 , издание 12 , страницы 2471-2479

Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones

Тип публикации: Journal Article

Дата публикации: 2019-12-01

Pleiades Publishing

Russian Journal of General Chemistry

scimago Q4

wos Q4

БС2

SJR: 0.179

CiteScore: 1.4

Impact factor: 0.8

ISSN: 10703632, 16083350

DOI: 10.1134/S1070363219120235

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General Chemistry

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A procedure has been developed and optimized for the synthesis of 3-{[4-methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones (as dihydrochlorides) by an unusual version of the Morita–Baylis–Hillman reaction. A number of the title compounds with various substituents in the chromene fragment and their deamination products have been synthesized, and their inhibitory activity against butyrylcholinesterase has been studied.

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Чернов Никита

к.х.н.

29 публикаций, 109 цитирований

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Санкт-Петербургский государственный химико-фармацевтический университет

Области научных интересов

Гетероциклические соединения

Медицинская химия

Органическая химия

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Russian Journal of General Chemistry	Russian Journal of General Chemistry, 1, 50% Russian Journal of General Chemistry 1 публикация, 50%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 1, 50% European Journal of Medicinal Chemistry 1 публикация, 50%
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Filippova P. V. et al. Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones // Russian Journal of General Chemistry. 2019. Vol. 89. No. 12. pp. 2471-2479.

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Filippova P. V., Chernov N. M., Shutov R. V., Yakovlev I. P. Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones // Russian Journal of General Chemistry. 2019. Vol. 89. No. 12. pp. 2471-2479.

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TY - JOUR

DO - 10.1134/S1070363219120235

UR - https://doi.org/10.1134/S1070363219120235

TI - Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones

T2 - Russian Journal of General Chemistry

AU - Filippova, P V

AU - Chernov, N M

AU - Shutov, R V

AU - Yakovlev, I P

PY - 2019

DA - 2019/12/01

PB - Pleiades Publishing

SP - 2471-2479

IS - 12

VL - 89

SN - 1070-3632

SN - 1608-3350

ER -

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@article{2019_Filippova,

author = {P V Filippova and N M Chernov and R V Shutov and I P Yakovlev},

title = {Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones},

journal = {Russian Journal of General Chemistry},

year = {2019},

volume = {89},

publisher = {Pleiades Publishing},

month = {dec},

url = {https://doi.org/10.1134/S1070363219120235},

number = {12},

pages = {2471--2479},

doi = {10.1134/S1070363219120235}

}

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Filippova, P. V., et al. “Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones.” Russian Journal of General Chemistry, vol. 89, no. 12, Dec. 2019, pp. 2471-2479. https://doi.org/10.1134/S1070363219120235.