Pleiades Publishing
Russian Journal of General Chemistry
,  том 89 ,  издание 12 ,  страницы 2471-2479

Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones

Тип публикации: Journal Article
Дата публикации: 2019-12-01
Pleiades Publishing
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ISSN: 10703632, 16083350
General Chemistry
Краткое описание
A procedure has been developed and optimized for the synthesis of 3-{[4-methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones (as dihydrochlorides) by an unusual version of the Morita–Baylis–Hillman reaction. A number of the title compounds with various substituents in the chromene fragment and their deamination products have been synthesized, and their inhibitory activity against butyrylcholinesterase has been studied.
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Filippova P. V. et al. Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones // Russian Journal of General Chemistry. 2019. Vol. 89. No. 12. pp. 2471-2479.
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Filippova P. V., Chernov N. M., Shutov R. V., Yakovlev I. P. Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones // Russian Journal of General Chemistry. 2019. Vol. 89. No. 12. pp. 2471-2479.
RIS |
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TY - JOUR
DO - 10.1134/S1070363219120235
UR - https://doi.org/10.1134/S1070363219120235
TI - Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones
T2 - Russian Journal of General Chemistry
AU - Filippova, P V
AU - Chernov, N M
AU - Shutov, R V
AU - Yakovlev, I P
PY - 2019
DA - 2019/12/01
PB - Pleiades Publishing
SP - 2471-2479
IS - 12
VL - 89
SN - 1070-3632
SN - 1608-3350
ER -
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@article{2019_Filippova,
author = {P V Filippova and N M Chernov and R V Shutov and I P Yakovlev},
title = {Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones},
journal = {Russian Journal of General Chemistry},
year = {2019},
volume = {89},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://doi.org/10.1134/S1070363219120235},
number = {12},
pages = {2471--2479},
doi = {10.1134/S1070363219120235}
}
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Filippova, P. V., et al. “Synthesis and Anticholinesterase Activity of 3-{[4-Methyl-3-(4-methylpiperazin-1-yl)]pent-1-en-1-yl}-4H-chromen-4-ones.” Russian Journal of General Chemistry, vol. 89, no. 12, Dec. 2019, pp. 2471-2479. https://doi.org/10.1134/S1070363219120235.
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