Expression of genes involved in DNA repair and telomere maintenance in the yeast Hansenula polymorpha DL1 under heat stress

185 Methylotrophic yeasts are widely used to study methanol metabolism, biogenesis and functions of peroxisomes, and as a “biofactory” to produce recom binant proteins. A characteristic feature of the Hansenula polymorpha DL1 strain ATCC 26012 is thermotolerance: these yeasts can grow at tempera tures up to 50°C [1]. This ability determines the higher thermal stability of proteins and nucleoprotein com plexes of these yeasts, which makes them an interest ing model object for studying the molecular processes such as DNA repair and telomere formation [2]. Pre viously, we determined the complete nucleotide sequence of the mitochondrial and nuclear genome of H. polymorpha DL1 and analyzed transcription when this strain was growth on glucose medium or methanol [3, 4].