Pleiades Publishing
Doklady Biochemistry and Biophysics
,  volume 474 ,  issue 1 ,  pages 173-177

Oxidation-induced modification of the fibrinogen polypeptide chains

Publication type: Journal Article
Publication date: 2017-05-01
Pleiades Publishing
scimago Q3
wos Q4
SJR: 0.223
CiteScore: 1.5
Impact factor: 0.7
ISSN: 16076729, 16083091
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract
By using the mass-spectrometry method, the oxidative modifications of the fibrinogen Aα, Bβ, and γ polypeptide chains induced by its oxidation have been studied. The αC-region has been proven to be the most vulnerable target for the oxidizer (ozone) as compared with the other structural elements of the Aα chain. The Bβ chain mapping shows that the oxidative sites are localized within all the structural elements of the chain in which the β-nodule exhibits high susceptibility to oxidation. The γ chains are the least vulnerable to the oxidizer action. The results obtained demonstrate convincingly that the self-assembly centers dealing with interactions of knob “A”: hole “a” are not involved in oxidative modification. It is concluded that the numerous oxidative sites revealed are mainly responsible for inhibiting lateral aggregation of protofibrils. The part of amino acid residues subjected to oxidation is supposed to carry out the antioxidant function.
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GOST |
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GOST Copy
Bychkova A. et al. Oxidation-induced modification of the fibrinogen polypeptide chains // Doklady Biochemistry and Biophysics. 2017. Vol. 474. No. 1. pp. 173-177.
GOST all authors (up to 50) Copy
Bychkova A., Vasilyeva A. D., Bugrova A. E., Indeykina M. I., Kononikhin A. S., Nikolaev E. N., Konstantinova M. L., Rosenfeld M. A. Oxidation-induced modification of the fibrinogen polypeptide chains // Doklady Biochemistry and Biophysics. 2017. Vol. 474. No. 1. pp. 173-177.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/S1607672917030115
UR - https://doi.org/10.1134/S1607672917030115
TI - Oxidation-induced modification of the fibrinogen polypeptide chains
T2 - Doklady Biochemistry and Biophysics
AU - Bychkova, A.V.
AU - Vasilyeva, A D
AU - Bugrova, A. E.
AU - Indeykina, M. I.
AU - Kononikhin, A. S.
AU - Nikolaev, E. N.
AU - Konstantinova, M L
AU - Rosenfeld, M. A.
PY - 2017
DA - 2017/05/01
PB - Pleiades Publishing
SP - 173-177
IS - 1
VL - 474
PMID - 28726089
SN - 1607-6729
SN - 1608-3091
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2017_Bychkova,
author = {A.V. Bychkova and A D Vasilyeva and A. E. Bugrova and M. I. Indeykina and A. S. Kononikhin and E. N. Nikolaev and M L Konstantinova and M. A. Rosenfeld},
title = {Oxidation-induced modification of the fibrinogen polypeptide chains},
journal = {Doklady Biochemistry and Biophysics},
year = {2017},
volume = {474},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.1134/S1607672917030115},
number = {1},
pages = {173--177},
doi = {10.1134/S1607672917030115}
}
MLA
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MLA Copy
Bychkova, A.V., et al. “Oxidation-induced modification of the fibrinogen polypeptide chains.” Doklady Biochemistry and Biophysics, vol. 474, no. 1, May. 2017, pp. 173-177. https://doi.org/10.1134/S1607672917030115.