Doklady Biochemistry and Biophysics, том 493, издание 1, номера страниц: 181-184

Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver

Тип документаJournal Article
Дата публикации2020-07
ИздательPleiades Publishing
Название журналаDoklady Biochemistry and Biophysics
Квартиль по SCImagoQ3
Квартиль по Web of ScienceQ4
Импакт-фактор 20210.83
ISSN16076729, 16083091
General Chemistry
General Medicine
Краткое описание
Long noncoding RNAs (lncRNAs) are promising biomarkers and potential targets for liver cancer therapy. Stable hepatocyte lines are used in vitro to investigate functions of lncRNAs which amount in cell fluctuates during carcinogenesis. For the first time we compared gene expression of known lncRNAs in human conditional normal liver cells HepaRG and cancer cell lines Huh7 and HepG2. We showed that relative amounts of these lncRNAs in HepaRG are close to analogous variables measured for liver samples from healthy donors. Obtained data demonstrate exclusive peculiarities of HepaRG and confirm its reasonable application as a model of normal human hepatocytes for studying functions of lncRNAs.
Пристатейные ссылки: 15
Цитируется в публикациях: 2
The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells
Zhang J., Han C., Song K., Chen W., Ungerleider N., Yao L., Ma W., Wu T.
Q1 PLoS ONE 2020 цитирований: 10
Open Access
Open access
Long noncoding RNA HULC promotes hepatocellular carcinoma progression
Zhang H., Liao Z., Liu F., Su C., Zhu H., Li Y., Tao R., Liang H., Zhang B., Zhang X.
Q2 Aging 2019 цитирований: 17
Open Access
Open access
Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma
Lim L.J., Wong S.Y., Huang F., Lim S., Chong S.S., Ooi L.L., Kon O.L., Lee C.G.
Q1 Cancer Research 2019 цитирований: 94
A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA
He J., Zuo Q., Hu B., Jin H., Wang C., Cheng Z., Deng X., Yang C., Ruan H., Yu C., Zhao F., Yao M., Fang J., Gu J., Zhou J., et. al.
Q1 Cancer Letters 2019 цитирований: 45
Activation of Polyamine Catabolism by N1,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype
Ivanova O.N., Snezhkina A.V., Krasnov G.S., Valuev-Elliston V.T., Khomich O.A., Khomutov A.R., Keinanen T.A., Alhonen L., Bartosch B., Kudryavtseva A.V., Kochetkov S.N., Ivanov A.V.
Q1 Cells 2018 цитирований: 9
Open Access
Open access
In vitro and in silico liver models: Current trends, challenges and opportunities
Poloznikov A.
Q1 Altex 2018 цитирований: 23
Open Access
Open access
Human hepatocyte systems for in vitro toxicology analysis
Kammerer S., Küpper J.
Q4 Journal of Cellular Biotechnology 2018 цитирований: 16
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
Nwosu Z.C., Battello N., Rothley M., Piorońska W., Sitek B., Ebert M.P., Hofmann U., Sleeman J., Wölfl S., Meyer C., Megger D.A., Dooley S.
Q1 Journal of Experimental and Clinical Cancer Research 2018 цитирований: 62
Open Access
Open access
Global Epidemiology, Prevention, and Management of Hepatocellular Carcinoma
Mak L., Cruz-Ramón V., Chinchilla-López P., Torres H.A., LoConte N.K., Rice J.P., Foxhall L.E., Sturgis E.M., Merrill J.K., Bailey H.H., Méndez-Sánchez N., Yuen M., Hwang J.P.
Q1 American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting 2018 цитирований: 108
Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures
Yokoyama Y., Sasaki Y., Terasaki N., Kawataki T., Takekawa K., Iwase Y., Shimizu T., Sanoh S., Ohta S.
Q2 Biological and Pharmaceutical Bulletin 2018 цитирований: 61
LINC00152 promotes cell cycle progression in hepatocellular carcinoma via miR-193a/b-3p/CCND1 axis
Ma P., Wang H., Sun J., Liu H., Zheng C., Zhou X., Lu Z.
Q1 Cell Cycle 2018 цитирований: 34
The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration
Li C., Chang L., Chen Z., Liu Z., Wang Y., Ye Q.
Q1 International Journal of Molecular Medicine 2017 цитирований: 22
The HepaRG Cell Line: Biological Properties and Relevance as a Tool for Cell Biology, Drug Metabolism, and Virology Studies
Marion M., Hantz O., Durantel D.
Q4 Methods in Molecular Biology 2010 цитирований: 63
Open Access
Open access
Hep G2 is a hepatoblastoma-derived cell line
López-Terrada D., Cheung S.W., Finegold M.J., Knowles B.B.
Q1 Human Pathology 2009 цитирований: 169
Origin and characterization of a human bipotent liver progenitor cell line☆
Parent R., Marion M., Furio L., Trépo C., Petit M.
Q1 Gastroenterology 2004 цитирований: 160


1. Burenina O.Y. и др. Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver // Doklady Biochemistry and Biophysics. 2020. Т. 493. № 1. С. 181–184.


DO - 10.1134/s1607672920040043

UR -

TI - Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver

T2 - Doklady Biochemistry and Biophysics

AU - Burenina, O. Y.

AU - Zatsepin, T. S.

AU - Kim, E. F.

AU - Metelin, A. V.

AU - Skvortsov, D. A.

AU - Rubtsova, M. P.

AU - Dontsova, O. A.

PY - 2020

DA - 2020/07

PB - Pleiades Publishing Ltd

SP - 181-184

IS - 1

VL - 493

SN - 1607-6729

SN - 1608-3091

ER -

BibTex |


doi = {10.1134/s1607672920040043},

url = {},

year = 2020,

month = {jul},

publisher = {Pleiades Publishing Ltd},

volume = {493},

number = {1},

pages = {181--184},

author = {O. Y. Burenina and T. S. Zatsepin and E. F. Kim and A. V. Metelin and D. A. Skvortsov and M. P. Rubtsova and O. A. Dontsova},

title = {Comparative Analysis of Long Noncoding {RNA} Expression in Human Hepatocyte Cell Lines and Liver}


Burenina, O. Y. et al. “Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver.” Doklady Biochemistry and Biophysics 493.1 (2020): 181–184. Crossref. Web.