Amphiphilic polymers in photodynamic therapy
A.B. Solov'eva
1
,
N A Aksenova
1
,
N N Glagolev
1
,
Ivanov A.V.
3
,
V. I. Volkov
4
,
A V Chernyak
4
Publication type: Journal Article
Publication date: 2012-05-01
scimago Q4
SJR: 0.244
CiteScore: 2.6
Impact factor: —
ISSN: 19907931, 19907923
Physical and Theoretical Chemistry
Abstract
It is shown that some amphiphilic polymers (AP), including, polyvinylpyrrolidone (PVP), which exhibit no their own photochemical activity, can increase the activity of porphyrin photosensitizers (PPS), the most effective and nontoxic types of dyes for photodynamic action on tumor cells. It is also shown that, under the model conditions of tryptophan photooxidation, addition of amphiphilic polymers increases the activity of carborane-substituted tetra(fluorophenyl)porphyrins, Photoditazine, and dimegin. According to NMR and fluorescence spectroscopy data, this phenomenon, known as polymer effect, is probably associated with the formation of AP-PPS complexes, a factor that prevents the aggregation of PPS, normally occurring in aqueous solutions, thereby enhancing the photosensitizing activity of PPS.
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15
Total citations:
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Citations from 2024:
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(13%)
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GOST
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Solov'eva A. et al. Amphiphilic polymers in photodynamic therapy // Russian Journal of Physical Chemistry B. 2012. Vol. 6. No. 3. pp. 433-440.
GOST all authors (up to 50)
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Solov'eva A., Aksenova N. A., Glagolev N. N., Melik-Nubarov N., A.V. I., Volkov V. I., Chernyak A. V. Amphiphilic polymers in photodynamic therapy // Russian Journal of Physical Chemistry B. 2012. Vol. 6. No. 3. pp. 433-440.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S1990793112060061
UR - https://doi.org/10.1134/S1990793112060061
TI - Amphiphilic polymers in photodynamic therapy
T2 - Russian Journal of Physical Chemistry B
AU - Solov'eva, A.B.
AU - Aksenova, N A
AU - Glagolev, N N
AU - Melik-Nubarov, N.S.
AU - A.V., Ivanov
AU - Volkov, V. I.
AU - Chernyak, A V
PY - 2012
DA - 2012/05/01
PB - Pleiades Publishing
SP - 433-440
IS - 3
VL - 6
SN - 1990-7931
SN - 1990-7923
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Solov'eva,
author = {A.B. Solov'eva and N A Aksenova and N N Glagolev and N.S. Melik-Nubarov and Ivanov A.V. and V. I. Volkov and A V Chernyak},
title = {Amphiphilic polymers in photodynamic therapy},
journal = {Russian Journal of Physical Chemistry B},
year = {2012},
volume = {6},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.1134/S1990793112060061},
number = {3},
pages = {433--440},
doi = {10.1134/S1990793112060061}
}
Cite this
MLA
Copy
Solov'eva, A.B., et al. “Amphiphilic polymers in photodynamic therapy.” Russian Journal of Physical Chemistry B, vol. 6, no. 3, May. 2012, pp. 433-440. https://doi.org/10.1134/S1990793112060061.