Nanotechnologies in Russia, volume 7, issue 1-2, pages 76-84
Antitumor activity of targeted nanosome delivery systems based on poly(lactic-co-glycolic acid) nanoparticles, paclitaxel, and a recombinant alpha-fetoprotein fragment
Godovannyi A V
1
,
Vorontsov E A
2
,
Gukasova N V
3
,
Pozdnyakova N V
2
,
Vasilenko E A
3
,
Yabbarov N G
2
,
Severin S. E.
2
,
Severin E S.
3
,
Gnuchev N. V.
1
3
Russian Research Center for Molecular Diagnostic and Therapy, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2012-02-01
Journal:
Nanotechnologies in Russia
Quartile SCImago
— Quartile WOS
—
Impact factor: 0.8
ISSN: 19950780, 19950799
Condensed Matter Physics
General Materials Science
General Engineering
Abstract
Biodegradable polymeric nanoparticles conjugated with targeting vector molecules have become prospective agents to improve the effectiveness of chemotherapeutic cancer treatment. This approach reduces the systemic toxicity of the drugs and increases the specificity of their uptake by cancer cells. A method has been developed to obtain complex nanoparticles loaded with the antitumor drug paclitaxel and a C-terminal fragment of recombinant oncofetal alpha-fetoprotein serving as a vector molecule, the in vitro cytotoxic activity of complex nanoparticles for MCF-7 human breast adenocarcinoma cells and resistant MDR1+ cells of the MCF-7Adr subline was shown to be higher than the cytotoxicity of the free drug and drug-loaded nanoparticles without the vector molecule. Moreover, the toxicity of complex paclitaxel-loaded nanoparticles against lymphocytes was low, which confirmed the selectivity of nanoparticle action. In summary, these results demonstrate that the strategy of active targeting of nanoparticles can efficiently enhance the antitumor activity of paclitaxel and it can solve the problem of reversing the multidrug resistance (MDR) of tumor cells.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Godovannyi A. V. et al. Antitumor activity of targeted nanosome delivery systems based on poly(lactic-co-glycolic acid) nanoparticles, paclitaxel, and a recombinant alpha-fetoprotein fragment // Nanotechnologies in Russia. 2012. Vol. 7. No. 1-2. pp. 76-84.
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Godovannyi A. V., Vorontsov E. A., Gukasova N. V., Pozdnyakova N. V., Vasilenko E. A., Yabbarov N. G., Severin S. E., Severin E. S., Gnuchev N. V. Antitumor activity of targeted nanosome delivery systems based on poly(lactic-co-glycolic acid) nanoparticles, paclitaxel, and a recombinant alpha-fetoprotein fragment // Nanotechnologies in Russia. 2012. Vol. 7. No. 1-2. pp. 76-84.
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TY - JOUR
DO - 10.1134/S1995078012010077
UR - https://doi.org/10.1134%2FS1995078012010077
TI - Antitumor activity of targeted nanosome delivery systems based on poly(lactic-co-glycolic acid) nanoparticles, paclitaxel, and a recombinant alpha-fetoprotein fragment
T2 - Nanotechnologies in Russia
AU - Godovannyi, A V
AU - Vorontsov, E A
AU - Gukasova, N V
AU - Pozdnyakova, N V
AU - Vasilenko, E A
AU - Yabbarov, N G
AU - Severin, S. E.
AU - Severin, E S.
AU - Gnuchev, N. V.
PY - 2012
DA - 2012/02/01 00:00:00
PB - Pleiades Publishing
SP - 76-84
IS - 1-2
VL - 7
SN - 1995-0780
SN - 1995-0799
ER -
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@article{2012_Godovannyi,
author = {A V Godovannyi and E A Vorontsov and N V Gukasova and N V Pozdnyakova and E A Vasilenko and N G Yabbarov and S. E. Severin and E S. Severin and N. V. Gnuchev},
title = {Antitumor activity of targeted nanosome delivery systems based on poly(lactic-co-glycolic acid) nanoparticles, paclitaxel, and a recombinant alpha-fetoprotein fragment},
journal = {Nanotechnologies in Russia},
year = {2012},
volume = {7},
publisher = {Pleiades Publishing},
month = {feb},
url = {https://doi.org/10.1134%2FS1995078012010077},
number = {1-2},
pages = {76--84},
doi = {10.1134/S1995078012010077}
}
Cite this
MLA
Copy
Godovannyi, A. V., et al. “Antitumor activity of targeted nanosome delivery systems based on poly(lactic-co-glycolic acid) nanoparticles, paclitaxel, and a recombinant alpha-fetoprotein fragment.” Nanotechnologies in Russia, vol. 7, no. 1-2, Feb. 2012, pp. 76-84. https://doi.org/10.1134%2FS1995078012010077.
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