Targeted delivery of doxorubicin: Drug delivery system based on PAMAM dendrimers

Yabbarov N.G., Posypanova G.A., Vorontsov E.A., Popova O.N., Severin E.S.
Тип документаJournal Article
Дата публикации2013-08-15
Название журналаBiochemistry (Moscow)
ИздательPleiades Publishing
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ4
Импакт-фактор 20212.82
ISSN00062979, 16083040
General Medicine
Краткое описание
Polyamidoamine (PAMAM) dendrimers of the second generation (G2) are branched polymers containing 16 surface amino groups that allow them to be used as universal carriers on creating systems for drug delivery. G2 labeled with fluorescein isothiocyanate (FITC) efficiently bound with the surface of tumor cells at 4°C and was absorbed by the cells at 37°C. The covalent binding to G2-FITC of a vector protein, a recombinant fragment of the human alpha-fetoprotein receptor-binding domain (rAFP3D), increased the binding and endocytosis efficiency more than threefold. Covalent conjugates of G2 with doxorubicin (Dox) obtained by acid-labile linking of cis-aconitic anhydride (CAA) without the vector protein (G2-Dox) and with the vector protein rAFP3D (rAFP3D-G2-Dox) were accumulated by the tumor cells with high efficiency. However, a selective effect was observed only in rAFP3D-G2-Dox, which also demonstrated high cytotoxic activity against the human ovarian adenocarcinoma SKOV3 cells and low cytotoxicity against human peripheral blood lymphocytes. Based on these results, rAFP3D-G2 conjugate is promising for selective delivery of antitumor drugs.
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1. Yabbarov N. G. и др. Targeted delivery of doxorubicin: Drug delivery system based on PAMAM dendrimers // Biochemistry (Moscow). 2013. Т. 78. № 8. С. 884–894.


DO - 10.1134/s000629791308004x

UR -

TI - Targeted delivery of doxorubicin: Drug delivery system based on PAMAM dendrimers

T2 - Biochemistry (Moscow)

AU - Yabbarov, N. G.

AU - Posypanova, G. A.

AU - Vorontsov, E. A.

AU - Popova, O. N.

AU - Severin, E. S.

PY - 2013

DA - 2013/08

PB - Pleiades Publishing Ltd

SP - 884-894

IS - 8

VL - 78

SN - 0006-2979

SN - 1608-3040

ER -

BibTex |


doi = {10.1134/s000629791308004x},

url = {},

year = 2013,

month = {aug},

publisher = {Pleiades Publishing Ltd},

volume = {78},

number = {8},

pages = {884--894},

author = {N. G. Yabbarov and G. A. Posypanova and E. A. Vorontsov and O. N. Popova and E. S. Severin},

title = {Targeted delivery of doxorubicin: Drug delivery system based on {PAMAM} dendrimers},

journal = {Biochemistry (Moscow)}


Yabbarov, N. G., et al. “Targeted Delivery of Doxorubicin: Drug Delivery System Based on PAMAM Dendrimers.” Biochemistry (Moscow), vol. 78, no. 8, Aug. 2013, pp. 884–94. Crossref,